Atherosclerosis and lipoprotein metabolism

Rang, H P; Dale, Martin; Ritter, James M.; Flower, Rod; Henderson, Glen R.

doi:10.1016/b978-0-443-06911-6.50025-6

Cited by 8 publications

(5 citation statements)

References 35 publications

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“…The primary source we used to identify potential warfarindrug and warfarin-disease interactions was the book Pharmacology, 7 From this volume, we obtained a list of warfarin interactions from the section on warfarin (pp. 321, 322).…”

Section: Ss Methodsmentioning

confidence: 99%

“…6 Warfarin, a medication that inhibits the synthesis of clotting factors, is the most commonly used oral anticoagulant today. [7][8][9] Warfarin acts by interfering with hepatic synthesis of vitamin K-dependent clotting factors (II, VII, IX, and X). 7,8,10,11 Physicians use warfarin for the treatment and prevention of venous thromboembolic disorders and the prevention of thromboembolic complications in patients with atrial fibrillation, valvular heart diseases, mechanical and bioprosthetic heart valves, and implanted artificial joints.…”

mentioning

confidence: 99%

“…7,14 Hemorrhage is a concern for warfarin monotherapy and for warfarin used concomitant with other drugs and in the presence of certain diseases. Of particular concern are warfarin users with heart failure (HF) who subsequently suffer from hepatic dysfunction and are at increased risk of hemorrhage.…”

mentioning

confidence: 99%

“…20 Individuals who use warfarin either concomitant with certain drugs, such as mifepristone, antiplatelet medications, aspirin, certain fibric acid derivatives, or metronidazole, or who are diagnosed with certain conditions, including liver disease, active bleeding, recent trauma, or blood dyscrasias, are at increased risk of hemorrhage. 7,12,20 While the potential dangers of warfarin drug-drug and drugdisease interactions and the prevalence of concomitant use of warfarin with drugs that may result in a drug-drug and drugdisease interaction are known, less is known about the prevalence of clinical consequences and the cost of these drug-drug and drug-disease interactions. Evidence of clinical and economic consequences of drug-drug and drug-disease interactions may help quantify the need for additional education and/or other interventions.…”

mentioning

confidence: 99%

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Administrative Claims Analysis of the Relationship Between Warfarin Use and Risk of Hemorrhage Including Drug-Drug and Drug-Disease Interactions

Zhang¹,

Young²,

Berger³

2006

JMCP

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CONCLUSIONS: Only 2 of 5 combinations of warfarin with drugs in this study were found to be associated with a higher prevalence of hemorrhage compared with warfarin use alone. The absolute prevalence of hemorrhage in users of warfarin and metronidazole was 22.7% and 17.2% for warfarin and cephalosporins, respectively, versus 14.2% in users of warfarin alone. The prevalence of hemorrhage for concomitant use of warfarin and NSAIDs/COX-2 inhibitors, amiodarone, or fibric acid derivatives such as fenofibrate was not greater than for warfarin alone. Liver disease or HF in warfarin users was associated with a significant increase in the likelihood of hemorrhage.

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Section: Ss Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

mentioning

confidence: 99%

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Administrative Claims Analysis of the Relationship Between Warfarin Use and Risk of Hemorrhage Including Drug-Drug and Drug-Disease Interactions

Zhang¹,

Young²,

Berger³

2006

JMCP

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“…HMGCR catalyses the conversion of HMG-CoA into mevalonate, ultimately leading to cholesterol synthesis [ 16 ]. LDLR maintains cholesterol homeostasis by a receptor-recycling pathway, in which circulating LDL-C is returned into the liver by receptor-mediated endocytosis [ 16 - 18 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Erxian decoction, a Chinese medicinal formulation, on serum lipid profile in a rat model of menopause

Sze

Cheung

et al. 2011

Chin Med

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BackgroundThe prevalence and risk of cardiovascular disease increase after menopause in correlation with the progression of abnormality in the serum lipid profile and the deprivation of estrogen. Erxian decoction (EXD), a Chinese medicinal formulation for treating menopausal syndrome, stimulates ovarian estrogen biosynthesis. This study investigates whether EXD improves the serum lipid profile in a menopausal rat model.MethodsTwenty-month-old female Sprague Dawley rats were treated with EXD and its constituent fractions. Premarin was administered for comparison. After eight weeks of treatment, rats were sacrificed and the serum levels of total cholesterol, triglyceride, high-density-lipoprotein cholesterol and low-density-lipoprotein cholesterol were determined. The hepatic protein levels of 3-hydroxy-3-methyl-glutaryl-CoA reductase and low-density-lipoprotein receptor were assessed with Western blot.ResultsThe serum levels of total cholesterol and low-density-lipoprotein cholesterol were significantly lower in the EXD-treated group than in the constituent fractions of EXD or premarin groups. However, the serum levels of triglyceride and high-density-lipoprotein cholesterol were not significantly different from the control groups. Results from Western blot suggest that EXD significantly down-regulated the protein level of 3-hydroxy-3-methyl-glutaryl-CoA reductase and up-regulated low-density-lipoprotein receptor. Conclusion EXD improves serum lipid profile in a menopausal rat model through the suppression of the serum levels of total cholesterol and low-density-lipoprotein cholesterol, possibly through the down-regulation of the 3-hydroxy-3-methyl-glutaryl-CoA and up-regulation of the low-density-lipoprotein receptor.

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Berberis lycium a Medicinal Plant with Immense Value

Sood

Modgil

Sood

2013

IJPBR

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Berberis lycium belong to family Berberidaceae is an evergreen shrub growing in Himalayan region. The various parts of the plant like root, bark, stem, leaves and fruits are used by the people as a medicine or food. This plant has also gained wide acceptance for its medicinal value in ayurvedic drugs. The plant is known to prevent liver disorders, abdominal disorders, skin diseases, cough, ophthalmic etc. Moreover the pharmacological studies have shown that plant is hypoglycemic, hyperlipidemic, hepatoprotective, anticarcinogenic and antipyretic properties. The fruits of the plant are also very nutritious and are rich source of vitamins, minerals, antioxidants, anthocyanin etc. These fruits are consumed in raw form or are utilized in the preparation of juices, jams, preserve etc. by the local inhabitants. In the present article an attempt has been made to summarize the various properties of Berberis lycium plant.

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Atherosclerosis and lipoprotein metabolism

Cited by 8 publications

References 35 publications

Administrative Claims Analysis of the Relationship Between Warfarin Use and Risk of Hemorrhage Including Drug-Drug and Drug-Disease Interactions

Administrative Claims Analysis of the Relationship Between Warfarin Use and Risk of Hemorrhage Including Drug-Drug and Drug-Disease Interactions

Effects of Erxian decoction, a Chinese medicinal formulation, on serum lipid profile in a rat model of menopause

Berberis lycium a Medicinal Plant with Immense Value

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