Atherosclerosis and liver inflammation induced by increased dietary cholesterol intake: a combined transcriptomics and metabolomics analysis

Kleemann, Robert; Verschuren, Lars; Erk, Marjan J. van; Nikolsky, Yuri; Cnubben, N.H.P.; Verheij, Elwin; Smilde, Age K.; Hendriks, H.; Zadelaar, Susanne; Smith, Graham J.; Kaznacheev, Valery; Nikolskaya, Tatiana; Мельников, А. С.; Hurt-Camejo, Eva; Greef, J. van der; Ommen, Ben van; Kooistra, Teake

doi:10.1186/gb-2007-8-9-r200

Cited by 213 publications

(205 citation statements)

References 36 publications

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“…49 Increased dietary cholesterol intake is associated with atherosclerosis. 50 The result of this study may suggest that men with a lower number of MetS components tend to abstain from eating eggs or cholesterol-rich foods. As a result, a doseresponse relationship between egg consumption and the number of MetS components was shown in our study.…”

Section: Dietary Factors and Metabolic Syndrome Components R Otsuka Ementioning

confidence: 77%

Relationship between number of metabolic syndrome components and dietary factors in middle-aged and elderly Japanese subjects

et al. 2010

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Metabolic syndrome (MetS) represents a cluster of risk factors for atherosclerosis and is considered a risk factor for cardiovascular disease. The role of diet in the etiology of MetS is poorly understood, especially among Asian subjects. This cross-sectional study assessed the relationship between diet and the number of MetS components among Japanese men (n¼609) and women (n¼631). Mean (s.d.) age and body mass index were 57.1 (12.1) years and 22.8 (2.8) kg m À2 for men and 55.5 (12.0) years and 22.0 (3.0) kg m À2 for women, respectively. Diet was assessed by a 3-day dietary record that included photographs: 16 nutrients, 11 food groups, and energy % of protein and dietary fat were selected as a dietary index. The definition of MetS was based on modified National Cholesterol Education Program, Adult Treatment Panel III criteria, and the number of clustering MetS components was calculated by adding the presence of each five MetS components. A total of 61 men (10.0%) and 46 women (7.3%) were determined to have MetS. After adjusting for age, energy intake, alcohol intake, smoking status and physical activity, a lower intake of vitamin B6 and dietary fiber in men, and lower intake of calcium, milk and dairy products and higher intake of cereal in women were related to the number of MetS components. These results suggest that some dietary factors were related to the number of MetS components among community-dwelling Japanese men and women. Keywords: cross-sectional study; dietary record; Japanese; metabolic syndrome INTRODUCTION Metabolic syndrome (MetS) represents a cluster of risk factors for atherosclerosis, including visceral obesity, hypertension, dyslipidemia and hyperglycemia; MetS is considered a risk factor for cardiovascular disease. 1 The National Nutrition Survey in Japan, a population-based study among 40-to 74-year-olds, revealed that 24% of men and 12% of women were strongly suspected of having MetS, and 27% of men and 8% of women were suspected of having MetS. 2 MetS has become a major public health challenge in Japan. 3 The pathophysiology of MetS appears to be largely attributable to insulin resistance with an excessive flux of fatty acids, 1 although this disorder presumably exists as a function of a complex interaction between environmental factors, including diet or physical activity and genetic factors. 4,5 Although dietary aspects have been linked to individual features of MetS, 6-8 the role of diet in the etiology of this syndrome is poorly understood. Asians have different lifestyle and genetic factors compared with Caucasians, 9,10 but only a few epidemiologic studies examining diet and MetS among Asians have been conducted. [11][12][13] The aim of this study was to examine the relations between diet and

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Section: Dietary Factors and Metabolic Syndrome Components R Otsuka Ementioning

confidence: 77%

Relationship between number of metabolic syndrome components and dietary factors in middle-aged and elderly Japanese subjects

et al. 2010

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“…They found elevated levels of xanthine and ascorbate in untreated mice which may be possible markers of plaque formation (Leo & Darrow, 2009). The interaction between diet and inflammation in promoting atherosclerosis has also been highlighted through metabolomic studies and Kleenmann (Kleemann et al, 2007) suggested that a high cholesterol intake lead to a switch in liver metabolism towards a pro-atherosclerotic state. Another recent example of how metabolomics can provide novel insights into inflammatory disease pathology was the observation that the metabolism of dietary lecithin by gut flora leads to the increased absorption and accumulation of choline derivatives which in turn promote cardiovascular disease (Wang et al, 2011) .…”

Section: Atherosclerosismentioning

confidence: 99%

Metabolomics in the Analysis of Inflammatory Diseases

et al. 2012

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“…Here we describe the impact of an LXR-agonist, T0901317, on the progression and regression of atherosclerosis in transgenic apoE*3Leiden (E3L) mice, a well-established mouse model for atherosclerosis (9,10). E3L mice are highly responsive to cholesterol-containing diets, resulting in strongly elevated plasma cholesterol and triglyceride levels, with a prominent increase in VLDL-and LDL-sized lipoprotein particles.…”

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confidence: 99%

LXR agonist suppresses atherosclerotic lesion growth and promotes lesion regression in apoE*3Leiden mice: time course and mechanisms

Verschuren

Weij

Zadelaar

et al. 2009

Journal of Lipid Research

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The aim of this study was to define the antiatherosclerotic role of liver-X-receptors (LXRs) under lesion progressive and lesion regressive conditions, to establish a temporal line of events, and to gain insights into the mechanisms underlying the anti-atherogenic potency of LXRs. We used apoE*3Leiden (E3L) mice to comprehensively and time-dependently dissect how T0901317, an LXR-agonist, inhibits initiation and progression of atherosclerotic lesions and regresses existing lipid-and macrophage-rich lesions. T0901317 suppresses lesion evolution and promotes lesion regression regarding lesion number, area, and severity. Quantitative plasma and vessel wall analyses corroborated by immunohistochemical evaluation of the aortic lesions revealed that under progressive (high-cholesterol diet) as well as regressive (cholesterol-free diet) conditions T0901317: i) significantly increases plasma triglyceride and total cholesterol levels; ii) does not affect the systemic inflammation marker, Serum amyloid A (SAA); iii) suppresses endothelial monocyte adhesion; and iv) induces the expression of the cholesterol efflux-related genes apolipoprotein E (apoE), ATP binding cassette (ABC) transporters ABCA1 and ABCG1. Furthermore, under progressive conditions, T0901317 suppresses the vascular inflammatory status (NF-kB) and the vascular expression of adhesion molecules [E-selectin, intercellular adhesion molecule (ICAM)-1, and CD44], lowers lesional macrophage accumulation, and blocks lesion evolution at the transition from lesional stage II to III. Under regressive conditions, T0901317 induces lesional macrophage disappearance and increases the expression of the chemokine receptor CCR7, a factor functionally required for regression. The LXR-agonist T0901317 retards vascular lesion development and promotes lesion regression at several levels.The findings support that vascular LXR is a potential antiatherosclerotic target.-Verschuren, L., J. de Vries-van der Weij, S. Zadelaar, R. Kleemann, and T. Kooistra. LXR agonist suppresses atherosclerotic lesion growth and promotes lesion regression in apoE*3Leiden mice: time course and mechanisms. J. Lipid Res. 2009. 50: 301-311.

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Atherosclerosis and liver inflammation induced by increased dietary cholesterol intake: a combined transcriptomics and metabolomics analysis

Cited by 213 publications

References 36 publications

Relationship between number of metabolic syndrome components and dietary factors in middle-aged and elderly Japanese subjects

Relationship between number of metabolic syndrome components and dietary factors in middle-aged and elderly Japanese subjects

Metabolomics in the Analysis of Inflammatory Diseases

LXR agonist suppresses atherosclerotic lesion growth and promotes lesion regression in apoE*3Leiden mice: time course and mechanisms

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