Atherosclerosis and physical activity

Schneider, Stephen H.; Vitug, Angelica C.; Ruderman, Neil B.

doi:10.1002/dmr.5610010410

Cited by 43 publications

(14 citation statements)

References 276 publications

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“…Thus, diet and exercise are frequently recommended together as the initial approach to therapy. Despite this practice, the potential role of exercise in NIDDM therapy has only begun to be clarified (3)(4)(5)(6)(7). There are several potential benefits of exercise for NIDDM patients.…”

Section: Potential Benefits Of Exercisementioning

confidence: 99%

“…Risk factors that may improve include plasma lipoprotein levels, hyperinsulinemia, hyperglycemia, some blood coagulation parameters, and blood pressure. (4). Weight loss.…”

Section: Potential Benefits Of Exercisementioning

confidence: 99%

“…Weight loss. A diet-induced decrease in adiposity is frequently associated with improvements in insulin resistance, glycemic control, and risk factors for coronary heart disease in patients with NIDDM (4,23,24). How-…”

Section: Potential Benefits Of Exercisementioning

confidence: 99%

“…Disease prevention. Exercise training may be a means of delaying the onset of insulin resistance, cardiovascular disease, and NIDDM in patients at high risk for developing these problems (4,5,7,(28)(29)(30). Those at risk include individuals with a positive family history of NIDDM or hypertriglyceridemia, women who have had gestational diabetes (28)(29)(30), and perhaps all people with android-type obesity.…”

Section: Technical Reviewmentioning

confidence: 99%

“…This recommendation is based on experimental evidence demonstrating that improvements in glycemic control and certain cardiovascular risk factors occur in some patients (4,10,(12)(13)(14)(15)(16)33,34). As noted earlier, people with NIDDM most likely to respond favorably are those with mildly to moderately impaired glucose tolerance and hyperinsulinemia.…”

Section: Guidelines For Exercisementioning

confidence: 99%

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Exercise and NIDDM

1991

Diabetes Care

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Section: Potential Benefits Of Exercisementioning

confidence: 99%

“…Risk factors that may improve include plasma lipoprotein levels, hyperinsulinemia, hyperglycemia, some blood coagulation parameters, and blood pressure. (4). Weight loss.…”

Section: Potential Benefits Of Exercisementioning

confidence: 99%

Section: Potential Benefits Of Exercisementioning

confidence: 99%

Section: Technical Reviewmentioning

confidence: 99%

Section: Guidelines For Exercisementioning

confidence: 99%

See 3 more Smart Citations

Exercise and NIDDM

1991

Diabetes Care

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Blood coagulability and fibrinolytic activity before and after physical training during the recovery phase of acute myocardial infarction

Suzuki

Yamauchi

Yamada

et al. 1992

Clinical Cardiology

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Summary:The effects of physical training on hemostatic parameters were evaluated in 56 postmyocardial infarction (MI) patients before and after one month of systematic physical training and in 30 control post-MI patients, who did not undergo such training. There were no significant changes in prothrombin time (PT) and alphal-antitrypsin (alAT) at the beginning and end of the study in either group. Levels of fibrinogen, Factor VIII: C (V1II:C) and von Wildebrand antigen (vWf Ag), and activities of ATIII and plasminogen (Plg) were significantly decreased in the group with physical training (pe 0.09, while values were unchanged in the control group. Hematocrit, platelet counts, and alpha2-plasmin inhibitor (a2PI) activities also decreased in the physical training group (pe 0.05). In contrast, these variables increased in the control group (p ~0 . 0 5 ) .Activated partial thromboplastin time (aP'lT) tended to be prolonged in the group with physical training, while it was shortened in the control group. In a subset of 20 patients with physical training, resting levels of plasmin-a2PI complex (PIC), thrombin-antithrombin I11 complex (TAT), protein-C (P-C:Ag), plasminogen activator inhibitor-1 (PAI-l), VII:C, and P-C activities had significantly decreased after one month of physical training (pc0.05), although tissue plasminogen activator activities remained unchanged. Physical training appeared to sup- press coagulability as indicated by the decrease in fibrinogen, VIII:C, vWf:Ag, VII:C, and TAT, and prolongation of aPTT. The decrease in plasminogen, t-PA:Ag, a2P1, PAI-1, and PIC after physical training may result from the decreased coagulability. In conclusion, physical training appears to induce a suppression of the coagulation system in patients in the recovery phase of MI.

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