Atherosclerosis and vascular calcification are independent predictors of left ventricular hypertrophy in chronic haemodialysis patients

Yildiz, Alaattin; Memisoglu, Esat; Oflaz, Hüseyin; Yazıcı, Halil; Püşüroğlu, Hamdi; Akkaya, Vakur; Erzengin, Faruk; Tepe, Savas

doi:10.1093/ndt/gfh611

Cited by 53 publications

(41 citation statements)

References 27 publications

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“…Calcifications at US were also common, affecting 36 (48%) of patients, a proportion comparable to the ones reported in previous studies, which varied from 50 to 64% [17][18][19] . Thirtythree out of our 36 patients with calcifications also exhibited increased IMT, whereas 10 patients with increased IMT did not have ultrasonographic calcifications.…”

Section: Discussionsupporting

confidence: 84%

Prevalência e correlatos de doença vascular no exame de ultrassom em pacientes em hemodiálise

Miguel¹,

Miguel²,

Velarde³

et al. 2011

Arq. Bras. Cardiol.

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Section: Discussionsupporting

confidence: 84%

Prevalência e correlatos de doença vascular no exame de ultrassom em pacientes em hemodiálise

Miguel¹,

Miguel²,

Velarde³

et al. 2011

Arq. Bras. Cardiol.

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“…Elevated Ca ϫ PO 4 is a risk factor for arterial calcification (26,27). Previous studies demonstrated a potential role of PTH in promoting myocardial fibrosis (8), but our data showed no correlation between LVMI and PTH.…”

Section: Pre-hd Bp and Ca ϫ Po 4 : Increased Afterloadcontrasting

confidence: 77%

Determinants of Left Ventricular Mass and Hypertrophy in Hemodialysis Patients Assessed by Cardiac Magnetic Resonance Imaging

Patel

Oliver

Mark

et al. 2009

Clinical Journal of the American Society of Nephrology

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“…Persistently high AIs after hemodialysis might be explained by the presence of vascular structural damage (44). Vascular calcification has been associated with LVH (45,46), adverse cardiovascular outcomes, and mortality in patients on MHD (47,48).…”

Section: Discussionmentioning

confidence: 99%

Changes in Pulse Pressure during Hemodialysis Treatment and Survival in Maintenance Dialysis Patients

Lertdumrongluk

Streja²,

Rhee

et al. 2015

Clinical Journal of the American Society of Nephrology

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Background and objectives Pulse pressure has been shown as a risk factor for mortality in patients on maintenance hemodialysis (MHD). However, the effect of change in pulse pressure during hemodialysis on survival in a large cohort of patients on MHD has not been sufficiently investigated.Design, setting, participants, & measurements This study examined the association between time-varying D pulse pressure (postdialysis minus predialysis pulse pressure) and mortality in a cohort of 98,577 patients on MHD (July 2001-June 2006) using Cox proportional hazard models with restricted cubic splines.Results The average patient age was 62 years old; among the patients, 33% were black and 59% had diabetes. During 134,814 patient-years of at-risk time, 16,054 (16%) patients died, with 6827 (43%) of the deaths caused by cardiovascular causes. In the models including adjustment for either predialysis systolic BP or mean arterial BP, there was a U-shaped association between change in pulse pressure during hemodialysis and all-cause mortality. In the systolic BP plus case mix plus malnutrition-inflammation complex syndrome-adjusted model, large declines in pulse pressure (.-25 mmHg) and increases in pulse pressure .5 mmHg were associated with higher all-cause mortality (reference: $-5 to ,5 mmHg): hazard ratios (95% confidence intervals [95% CIs]) for change pulse pressures of ,-25, $-25 to ,-15, $-15 to ,-5, 5 to ,15, 15 to ,25, and $25 mmHg were 1.21 (95% CI, 1.14 to 1.29), 1.03 (95% CI, 0.97 to 1.10), 1.01 (95% CI, 0.96 to 1.06), 1.06 (95% CI, 1.01 to 1.11), 1.17 (95% CI, 1.11 to 1.24), and 1.15 (95% CI, 1.08 to 1.23), respectively. The U-shaped association was observed with cardiovascular death.Conclusions Modest reductions in pulse pressure after hemodialysis are associated with the greatest survival, whereas large declines or rises in pulse pressure are related to higher mortality. Trials determining how to modify pulse pressure response to improve survival in the hemodialysis population are indicated.

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Atherosclerosis and vascular calcification are independent predictors of left ventricular hypertrophy in chronic haemodialysis patients

Abstract: Extra-coronary atherosclerosis and vascular calcification are associated with LVH in HD patients. Whether the treatment of atherosclerosis or vascular calcification may cause regression of or even prevent LVH in HD patients remains to be seen.

Cited by 53 publications

References 27 publications

Prevalência e correlatos de doença vascular no exame de ultrassom em pacientes em hemodiálise

Prevalência e correlatos de doença vascular no exame de ultrassom em pacientes em hemodiálise

Determinants of Left Ventricular Mass and Hypertrophy in Hemodialysis Patients Assessed by Cardiac Magnetic Resonance Imaging

Changes in Pulse Pressure during Hemodialysis Treatment and Survival in Maintenance Dialysis Patients

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