Atherosclerosis‐associated endothelial cell apoptosis by miRNA let7‐b‐mediated downregulation of HAS‐2

Zhu, Lihua; Li, Qingman; Qi, Datun; Niu, Fangqing; Li, Qingmin; Yang, Haiyan; Gao, Chuanyu

doi:10.1002/jcb.29537

Cited by 11 publications

(4 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As such, the induction of endothelial interferogenic responses induced by small RNAs bound to NETs may be highly conducive to vascular damage. The roles of endogenous miR-let-7b in endothelial function are complex and may also involve protecting these cells from oxidation (44)(45)(46)(47). Consequently, future studies should comprehensively address how this NET-bound small RNA modulates overall vascular health in SLE and other inflammatory diseases.…”

Section: Discussionmentioning

confidence: 99%

RNA Externalized by Neutrophil Extracellular Traps Promotes Inflammatory Pathways in Endothelial Cells

Blanco

Wang

Carlucci

et al. 2021

Arthritis & Rheumatology

View full text Add to dashboard Cite

Objective. Neutrophil extracellular traps (NETs) are extracellular lattices composed of nucleic material bound to neutrophil granule proteins. NETs may play pathogenic roles in the development and severity of autoimmune diseases such as systemic lupus erythematosus (SLE), at least in part, through induction of type I interferon (IFN) responses via externalization of oxidized immunostimulatory DNA. A distinct subset of SLE proinflammatory neutrophils (lowdensity granulocytes [LDGs]) displays enhanced ability to form proinflammatory NETs that damage the vasculature. We undertook this study to assess whether NET-bound RNA can contribute to inflammatory responses in endothelial cells (ECs) and the pathways that mediate this effect.Methods. Expression of newly synthesized and total RNA was quantified in NETs from healthy controls and lupus patients. The ability of ECs to take up NET-bound RNA and downstream induction of type I IFN responses were quantified. RNAs present in NETs were sequenced and specific small RNAs were tested for induction of endothelial type I IFN pathways.Results. NETs extruded RNA that was internalized by ECs, and this was enhanced when NET-bound nucleic acids were oxidized, particularly in lupus LDG-derived NETs. Internalization of NET-bound RNA by ECs was dependent on endosomal Toll-like receptors (TLRs) and the actin cytoskeleton and induced type I IFN-stimulated genes (ISGs). This ISG induction was dependent on NET-associated microRNA let-7b, a small RNA expressed at higher levels in LDGderived NETs, which acted as a TLR-7 agonist.Conclusion. These findings highlight underappreciated roles for small RNAs externalized in NETs in the induction of proinflammatory responses in vascular cells, with implications for lupus vasculopathy.

show abstract

Section: Discussionmentioning

confidence: 99%

RNA Externalized by Neutrophil Extracellular Traps Promotes Inflammatory Pathways in Endothelial Cells

Blanco

Wang

Carlucci

et al. 2021

Arthritis & Rheumatology

View full text Add to dashboard Cite

show abstract

“…The let-7 family has a tumor-suppressive function and is highly expressed in endothelial cells and VSMCs [ 123 ]. They stimulate eNOS, prevent the activation of the NF-κB pathway, and inhibit the apoptosis of endothelial cells [ 167 , 168 ].…”

Section: The Role Of Micrornas In Atherosclerosis Psoriasis T2dm and Ramentioning

confidence: 99%

A Review of MicroRNAs and lncRNAs in Atherosclerosis as Well as Some Major Inflammatory Conditions Affecting Atherosclerosis

Letonja,

Petrovič

2024

Biomedicines

View full text Add to dashboard Cite

It is generally accepted that atherosclerosis is a chronic inflammatory disease. The link between atherosclerosis and other inflammatory diseases such as psoriasis, type 2 diabetes mellitus (T2DM), and rheumatoid arthritis (RA) via metabolic, inflammatory, and immunoregulatory pathways is well established. The aim of our review was to summarize the associations between selected microRNAs (miRs) and long non-coding RNAs (lncRNAs) and atherosclerosis, psoriasis, T2DM, and RA. We reviewed the role of miR-146a, miR-210, miR-143, miR-223, miR-126, miR-21, miR-155, miR-145, miR-200, miR-133, miR-135, miR-221, miR-424, let-7, lncRNA-H19, lncRNA-MEG3, lncRNA-UCA1, and lncRNA-XIST in atherosclerosis and psoriasis, T2DM, and RA. Extracellular vesicles (EVs) are a method of intracellular signal transduction. Their function depends on surface expression, cargo, and the cell from which they originate. The majority of the studies that investigated lncRNAs and some miRs had relatively small sample sizes, which limits the generalizability of their findings and indicates the need for more research. Based on the studies reviewed, miR-146a, miR-155, miR-145, miR-200, miR-133, and lncRNA-H19 are the most promising potential biomarkers and, possibly, therapeutic targets for atherosclerosis as well as T2DM, RA, and psoriasis.

show abstract

“…The let-7 family has a tumor suppressive function and is highly expressed in endothelial cells and VSMCs [114]. They stimulate eNOS, prevent activation of the NF-κB pathway and inhibit apoptosis of endothelial cells [157,158].…”

Section: Let-7mentioning

confidence: 99%

Review of microRNAs and lncRNAs in atherosclerosis, diabetes, and other inflammatory conditions

Letonja,

Petrovič

2023

Preprint

View full text Add to dashboard Cite

It is generally accepted that atherosclerosis is a chronic inflammatory disease. The link between atherosclerosis and other inflammatory diseases such as psoriasis, type 2 diabetes mellitus (T2DM), and rheumatoid arthritis (RA) via metabolic, inflammatory, and immunoregulatory pathways is well established. The aim of our review was to summarize the associations between selected microRNAs (miRs) and long non-coding RNAs (lncRNAs) and atherosclerosis, psoriasis, T2DM, and RA. MicroRNAs are short noncoding RNA molecules involved in cell signaling, intracellular communication, and gene expression. We reviewed the role of miR-146a, miR-210, miR-143, miR-223, miR-126, miR-21, miR-155, miR-145, miR-200, miR-133, miR-135, miR-221, miR-424, and let-7 in atherosclerosis, psoriasis, T2DM, and RA. LncRNAs are RNA transcripts longer than 200 nucleotides that are involved in cellular processes such as apoptosis, metabolism, inflammation, cell differentiation, and proliferation. We evaluated the role of lncRNA-H19, lncRNA-MEG3, lncRNA-UCA1, and lncRNA-XIST in atherosclerosis and psoriasis, T2DM, and RA. Extracellular vesicles (EVs) are a method of intracellular signal transduction. Their function depends on surface expression, cargo, and the cell from which they originate.

show abstract

Atherosclerosis‐associated endothelial cell apoptosis by miRNA let7‐b‐mediated downregulation of HAS‐2

Cited by 11 publications

References 43 publications

RNA Externalized by Neutrophil Extracellular Traps Promotes Inflammatory Pathways in Endothelial Cells

RNA Externalized by Neutrophil Extracellular Traps Promotes Inflammatory Pathways in Endothelial Cells

A Review of MicroRNAs and lncRNAs in Atherosclerosis as Well as Some Major Inflammatory Conditions Affecting Atherosclerosis

Review of microRNAs and lncRNAs in atherosclerosis, diabetes, and other inflammatory conditions

Contact Info

Product

Resources

About