Atherosclerosis in diabetes: The role of hyperinsulinemia

Stolar, Mark W.

doi:10.1016/0026-0495(88)90180-1

Cited by 141 publications

(50 citation statements)

References 48 publications

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“…DM macroangiopathy is a condition in which fat and blood clots stick to and build up in the macrovessels. This disorder affects the heart, brain, and peripheral macrovessels, with atherosclerosis (AS) as its pathological basis (3). However, DM macroangiopathy has a broader area of focus, greater severity, and earlier pathology than pure AS.…”

Section: Introductionmentioning

confidence: 99%

Association of APOE polymorphisms and insulin resistance with TCM syndromes in type 2 diabetes patients with macroangiopathy

Xie

Wang

et al. 2011

Mol Med Report

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Abstract.To investigate the association between apolipoprotein E (APOE) polymorphisms and insulin resistance and Traditional Chinese Medicine (TCM) syndromes in type 2 diabetes mellitus (T2DM) with macroangiopathy, 60 patients with T2DM macroangiopathy were enrolled and divided into three groups: dryness-heat due to deficiency of yin, Qi-Yin deficiency, and Yin-Yang deficiency, according to the TCM syndromes, with a control group of 20 healthy individuals. APOE genotype analysis was performed with polymerase chain reaction amplification and restriction fragment length polymorphism, and the results showed that the proportion of the ε4/4 and ε3/4 genotypes and frequencies of the ε4 and ε3 alleles were higher in the Qi-Yin deficiency group (P<0.05). Among the T2DM macroangiopathy patients, the E4 group had the largest number of cases, as well as a significantly longer disease course compared to the E2 group (P<0.05). The insulin resistance index (IRI), insulin action index and body mass index (BMI) of patients in the Yin-Yang deficiency group were significantly different from those of patients with dryness-heat due to deficiency of yin and Qi-Yin deficiency. Furthermore, correlation analysis of the BMI and IRI of patients in the Yin-Yang deficiency group revealed a correlation coefficient r= 0.696 (P<0.01) and a typical correlation between them. In conclusion, the Qi-Yin deficiency in T2DM patients with macroangiopathy is associated with the APOE E4 and E3 genotypes. Thus, the APOE gene polymorphism can, to some degree, reflect the TCM syndrome types of T2DM patients with macroangiopathy. Insulin resistance plays an important role in the occurrence of T2DM macroangiopathy and is closely associated with the Yin-Yang deficiency according to the TCM differentiating types.

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Section: Introductionmentioning

confidence: 99%

Association of APOE polymorphisms and insulin resistance with TCM syndromes in type 2 diabetes patients with macroangiopathy

Xie

Wang

et al. 2011

Mol Med Report

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“…Our object here is to avoid peripheral hyperinsulinemia with its morbid sequellae of hypoglycemia, atherosclerosis [6][7], heart disease [8], altered lipid metabolism, hypertension [9], and impaired hemostasis [10]. Achieving peripheral euinsulinemia in diabetic patients is our goal when portal insulin is given in adequate amounts to control diabetes.…”

Section: Discussionmentioning

confidence: 99%

Avoiding Toxicity: Insulin Placement in the Portal Vein

Murphy¹,

Winchester²

2013

Cureus

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“…Moreover, physiological concentrations of insulin possess a dose-dependent inhibitory action on platelet aggregation and inhibit intracellular uptake of calcium [19][20][21] . Several experimental studies using animal models or arterial tissue in vitro suggested that insulin has a direct atherogenic effect 22,23) . In contrast, the association of a low insulin level with atherosclerosis has gained some support from previous studies 3,4,[24][25][26][27] .…”

Section: Discussionmentioning

confidence: 99%

U-Shaped Relationship between Insulin Level and Coronary Artery Calcification (CAC)

Tanaka

Fukui

Tomiyasu³

et al. 2010

JAT

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Aim: Recent studies have suggested that hyperinsulinemia is associated with high cardiovascular risk. The purpose of this study was to assess the relationship between the serum insulin level and coronary artery calcification (CAC). Methods: We performed a cross-sectional study of 582 consecutive and nondiabetic participants with clinical suspicion of coronary heart disease, and assessed the CAC score determined by multislice computed tomography. A standard 75-g oral glucose tolerance test was performed and venous blood was collected at 0, 30, 60 and 120 min for the measurement of plasma glucose and serum insulin.

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Atherosclerosis in diabetes: The role of hyperinsulinemia

Cited by 141 publications

References 48 publications

Association of APOE polymorphisms and insulin resistance with TCM syndromes in type 2 diabetes patients with macroangiopathy

Association of APOE polymorphisms and insulin resistance with TCM syndromes in type 2 diabetes patients with macroangiopathy

Avoiding Toxicity: Insulin Placement in the Portal Vein

U-Shaped Relationship between Insulin Level and Coronary Artery Calcification (CAC)

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