Atherosclerosis in Juvenile Idiopathic Arthritis

Jednacz, Ewa; Rutkowska-Sak, Lidia

doi:10.1155/2012/714732

Cited by 26 publications

(25 citation statements)

References 33 publications

(30 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The administration of IL-6 to mice susceptible to atherosclerosis and to mice resistant to atherosclerosis receiving a cholesterol-rich diet resulted in atherosclerotic lesions developing only in mice susceptible to atherosclerosis [ 37 ]. The increased levels of proinflammatory cytokines are observed in RA [ 38 ], similarly in children with JIA [ 39 ]. In studies on patients with RA, IL-6 played an especially vital role in the vascular endothelial activation [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Assessment of the Body Composition and Parameters of the Cardiovascular Risk in Juvenile Idiopathic Arthritis

Jednacz

Rutkowska-Sak

2015

BioMed Research International

Self Cite

View full text Add to dashboard Cite

The study was aimed to evaluate cardiovascular risk parameters, body mass index (BMI) centiles for sex and age, and body fat percentage using the electric bioimpedance method in children with juvenile idiopathic arthritis (JIA). 30 children with JIA participated in the study. A control group included 20 children. Patients were well matched for the age and sex. The body mass and body fat percentage were determined using the segmental body composition analyser; the BMI centiles were determined. All patients had the following parameters determined: lipid profile, hsCRP, homocysteine, and IL-6. The intima media thickness (IMT) was measured. Patients with JIA had significantly lower body weight, BMI, and the BMI centile compared to the control group. The IL-6 levels were significantly higher in patients with JIA compared to the control group. There were no differences between two groups with regard to the lipid profile, % content of the fat tissue, homocysteine levels, hsCRP, and IMT. Further studies are necessary to search for reasons for lower BMI and BMI centile in children with JIA and to attempt to answer the question of whether lower BMI increases the cardiovascular risk in these patients, similarly as in patients with rheumatoid arthritis (RA).

show abstract

Section: Discussionmentioning

confidence: 99%

Assessment of the Body Composition and Parameters of the Cardiovascular Risk in Juvenile Idiopathic Arthritis

Jednacz

Rutkowska-Sak

2015

BioMed Research International

Self Cite

View full text Add to dashboard Cite

show abstract

“…To date, it has been shown that multiple rheumatic diseases including RA, scleroderma, ankylosing spondylitis, systemic lupus erythematosus and gout may be associated with hyperhomocysteinemia, which may, in turn, be associated with cardiovascular events (6)(7)(8)(9). In many studies that examined serum Hcy levels in rheumatic disease, serum Hcy levels were higher in the case group than the control group (6)(7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

Plasma Homocysteine Concentrations In Patients With Rheumatoid Arthritis

Vasiljevic

Lucic

Živanović³

et al. 2015

Serbian Journal of Experimental and Clinical Research

View full text Add to dashboard Cite

In this study, we investigated the concentration of serum homocysteine (Hcy) in patients with rheumatoid arthritis (RA) compared with the control group and the connection between homocysteine and parameters of inflammation and disease activity. Sixty RA patients and 20 healthy controls were included in the study, and clinical examination and investigation were performed during which disease activity was assessed. Peripheral blood samples were used for all of the assays. Levels of Hcy were 33% higher in the RA patients than in the control subjects (mean +/− SD 11.79±3.72 μmol/L versus 8.90±1.38 μmol/L; p< 0.01). A significant correlation was found between parameters of inflammation (C-reactive protein) and homocysteine in patients (r=0.322, p=0.012). Patients with high disease activity had a significantly greater increase in homocysteine (p<0.05). An increase in plasma homocysteine in RA patients is related to the parameters of inflammation and disease activity. Elevated Hcy levels occur commonly in patients with RA and may explain some of the increased cardiovascular mortality seen in RA patients.

show abstract

“…There are very scarce published data on subclinical atherosclerosis in patients with JIA, reviewed in [10]. Recent studies showed increased IMT in JIA children or impaired endothelial function in these patients [11, 12].…”

Section: Introductionmentioning

confidence: 99%

Subclinical Cardiovascular System Changes in Obese Patients with Juvenile Idiopathic Arthritis

Głowińska-Olszewska

Bossowski

Dobreńko

et al. 2013

Mediators of Inflammation

View full text Add to dashboard Cite

Objective. We aimed to determine the prevalence of excess body mass in juvenile idiopathic arthritis (JIA) children and to investigate the influence of obesity into the early, subclinical changes in cardiovascular system in these patients. Methods. Fifty-eight JIA patients, aged median 13 years, were compared to 36 healthy controls. Traditional cardiovascular risk factors and inflammatory markers (hsCRP, IL-6, TNFα, adiponectin) were studied together with IMT (intima-media thickness), FMD (flow mediated dilation), and LVMi (left ventricle mass index) as surrogate markers of subclinical atherosclerosis. Results. Thirteen JIA children (22%) were obese and had increased systolic blood pressure, cholesterol, triglycerides, insulin, HOMA, hsCRP, and IL-6 compared to nonobese JIA and controls. FMD was decreased compared to nonobese JIA and controls, whereas IMT and LVMi were increased. In multivariate regression analysis, TNFα, SDS-BMI, and systolic blood pressure were independent predictors of early CV changes in JIA. Conclusions. Coincident obesity is common in JIA children and is associated with insulin resistance, dyslipidemia, and increased levels of inflammatory markers leading to early changes in cardiovascular system. Thus, medical care of children with JIA should include strategies preventing cardiovascular disease by maintenance of adequate body weight.

show abstract

Atherosclerosis in Juvenile Idiopathic Arthritis

Cited by 26 publications

References 33 publications

Assessment of the Body Composition and Parameters of the Cardiovascular Risk in Juvenile Idiopathic Arthritis

Assessment of the Body Composition and Parameters of the Cardiovascular Risk in Juvenile Idiopathic Arthritis

Plasma Homocysteine Concentrations In Patients With Rheumatoid Arthritis

Subclinical Cardiovascular System Changes in Obese Patients with Juvenile Idiopathic Arthritis

Contact Info

Product

Resources

About