Atherosclerosis is Associated Comorbidity in Patients with Chronic Obstructive Pulmonary Disease: Ultrasound Assessment of Carotid Intima Media Thickness

Hafez, Manal R.; Sobh, Eman; Abo-Elkheir, Omaima I.; Sakr, Lobna K.

doi:10.5152/ejp.2016.63626

Cited by 2 publications

(2 citation statements)

References 40 publications

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“…In the study of Hafez et al [ 58 ], patients with COPD and healthy individuals were compared and CIMT was discussed. Spirometric values and demographic characteristics of the patients and control group were examined.…”

Section: Discussionmentioning

confidence: 99%

“…In a meta-analysis [ 39 ], CIMT was found to be 0.76 mm ± 0.17 in patients with myocardial infarction, 0.77 mm ± 0.18 in those with a cerebrovascular stroke, and more than 0.82 mm ± 0.17 in those with both myocardial infarction and cerebrovascular stroke. In the study of Hafez et al [ 58 ], CIMTs were 0.63±0.076 mm in the control group and 0.85±0.18 mm in the COPD group. In our study, the mean CCA intima-media thickness in the COPD group was 0.8746±0.161, and the mean CCA intima-media thickness in the control group was 0.6650±0.139.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of atherosclerosis as a risk factor in COPD patients by measuring the carotid intima-media thickness

Firincioglulari,

Erturk,

Firincioglulari

et al. 2024

Cardiovasc Ultrasound

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Background This study aimed to evaluate atherosclerosis as comorbidity by measuring the carotid (bulb and common carotid artery) Carotid intima-media thickness in COPD-diagnosed patients and to evaluate the relationship of atherosclerosis with the prevalence of COPD, hypoxemia and hypercapnia. Methods This study was conducted out between January 2019-December 2019 consisting of a total of 140 participants (70 COPD-diagnosed patients-70 healthy individuals). The COPD-diagnosed patients have been planned according to the selection and diagnosis criteria as per the GOLD 2019 guide. It is planned to evaluate as per prospective matching case-control study of the carotid thickness, radial gas analysis, spirometric and demographic characteristics of COPD diagnosed patients and healthy individuals. Results The average Carotid intima-media thickness in COPD patients was 0.8746±0.161 (p<0.05), and the thickness of the carotid bulb was 1.04±0.150 (p<0.05). In the control group, the average CCA intima-media thickness was 0.6650±0.139 (p<0.05), and the thickness of the carotid bulb was 0.8250±0.15(p<0.05) For the carotid thickness that has increased in COPD diagnosed patients a significant relationship is determined between hypoxemia (p<0.05) and hypercapnia(p<0.05). A significant relationship determined between CIMT and severity of COPD (p<0.05) The CIMT was high in COPD patients with hypoxemia and hypercapnia(p<0.05). Conclusion Significant difference was determined between the severity (grades) of COPD (mild, moderate, severe, very severe) in carotid thickness. Also, CIMT was found to be high in patients who is in the early phases of the prevalence of COPD. In COPD-diagnosed patients, it was determined that severity of COPD, hypoxemia, hypercapnia and age were determining factors of atherosclerosis. Graphical Abstract

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of atherosclerosis as a risk factor in COPD patients by measuring the carotid intima-media thickness

Firincioglulari,

Erturk,

Firincioglulari

et al. 2024

Cardiovasc Ultrasound

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Pulmonary emphysema and atherosclerosis: association or syndrome?

Elrefai

Alsayyad

Dawood

2020

Egypt J Radiol Nucl Med

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Background Atherosclerosis is an inflammatory reaction of the vessel wall. Emphysema may induce systemic inflammation, part of which may be the development or progression of atherosclerosis. So, the relationship between emphysema and atherosclerosis, whether both are due to the same causative agent and pathogenesis or emphysema led to atherosclerosis, is still not clearly understood. So, the aim of this work is to study the relationship between carotid atherosclerosis versus pulmonary emphysema extent and airflow obstruction. Results Cigarette smoking index was higher in patients than controls. According to FEV1%, patients were classified into: GOLD 1 (mild): FEV1 ≥ 80% predicted, GOLD 2 (moderate): 50% ≤ FEV1 < 80% predicted, GOLD 3 (severe):30% ≤ FEV1 < 50% predicted, and GOLD 4 (very severe): FEV1 < 30% predicted. There was a significant difference between the studied groups as regard to ABG parameters. Emphysema score showed a positive correlation with thrombus size, plaque size, and stenosis percent. Approximately 2/3 of patients had atherosclerotic changes and the other 1/3 had increased IMT. GOLD staging, also, correlated with thrombus size and stenosis percent. So, there was a strong positive correlation between both emphysema score and GOLD staging and carotid atherosclerosis. Conclusion The relationship between emphysema and atherosclerosis is suggested to be the chronic inflammatory reaction (against the same risk factor) based on the positive correlation between carotid atherosclerosis versus emphysema score and GOLD staging. The inherence of emphysema and atherosclerosis may be considered a syndrome. If so, targeting the same pathogenic mechanism will be valuable for their control.

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Atherosclerosis is Associated Comorbidity in Patients with Chronic Obstructive Pulmonary Disease: Ultrasound Assessment of Carotid Intima Media Thickness

Cited by 2 publications

References 40 publications

Evaluation of atherosclerosis as a risk factor in COPD patients by measuring the carotid intima-media thickness

Evaluation of atherosclerosis as a risk factor in COPD patients by measuring the carotid intima-media thickness

Pulmonary emphysema and atherosclerosis: association or syndrome?

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