2020
DOI: 10.21203/rs.3.rs-30047/v1
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Atherosclerosis is attenuated by acacetin via Sirt1-mediated activation of AMPK/Sirt3 signals in diabetic ApoE-/- mice

Abstract: BackgroundThe strategy of decreasing atherosclerotic cardiovascular disorder is imperative to reduce premature death and improve quality of life in patients with diabetes mellitus. The present study was designed to investigate whether the natural flavone acacetin could improve diabetes- accelerated atherosclerotic lesions.MethodsDiabetic model was established in 7-week-old ApoE−/− mice by intraperitoneal injection of STZ (daily 50 mg/kg) for 5 days. Animals of control, control with acacetin treatment, STZ-diab… Show more

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“…This manuscript has been released as a pre-print at Research Square in pre-print form (Han et al, 2020).…”
Section: Acknowledgmentsmentioning
confidence: 99%
“…This manuscript has been released as a pre-print at Research Square in pre-print form (Han et al, 2020).…”
Section: Acknowledgmentsmentioning
confidence: 99%