Atherosclerosis, myocardial infarction and primary hemostasis: Impact of platelets, von Willebrand factor and soluble glycoprotein VI

Villmann, Josepha-Maria; Burkhardt, Ralph; Teren, Andrej; Villmann, Thomas; Thiery, Joachim; Drogies, Tim

doi:10.1016/j.thromres.2019.06.014

Cited by 8 publications

(9 citation statements)

References 48 publications

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“…As the MPV increases, the expression of glycoprotein Ib and glycoprotein IIb/IIIa receptors on its surface increases. Large platelets have denser granules where more proagretory factors [16,17]. In our study, we found higher MPV levels in non-dipper patients compared to the control group and the other two groups.…”

Section: Discussionsupporting

confidence: 54%

Is there a difference between normotensive and hypertensive patients in terms of blood parameters and cardiovascular diseases?

Aydın

Alpsoy

Engin

et al. 2021

The European Research Journal

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Objectives: It has been stated in various studies that there is a difference in some blood parameters between hypertensive and normotensive patients for a long time. Mean platelet volume (MPV), and red blood cell distribution width (RDW), have been studied in hypertensive patient groups in many studies. Hypertension is a classic risk factor for ischemic stroke and myocardial ischemia, as known. In our study, we examined whether there was a difference between hypertensive patient groups and normotensive patients in terms of blood parameters such as MPV and RDW, and the incidence of stroke and myocardial infarction. Methods: Blood samples and twenty-four-hour ambulatory blood pressure monitoring (ABPM) results of 552 patients admitted to our outpatient clinic with a pre-diagnosis of hypertension were retrospectively analyzed. According to ABPM results, we divided the study participants into four groups; dippers, non-dippers, extreme dippers, and normotansives. Complete blood count and biochemical test results were found in the database of our hospital for all patients and differences between groups were investigated. Results: One hundred seventy three normotensives (Group 1) (mean age, 47.4 ± 15.4 years), 210 non-dippers (Group 2) (mean age, 53.8 ± 15.8 years), 67 extreme dippers (Group 3) (mean age, 49.1 ± 15.9 years) and 102 dippers (Group 4) (mean age, 52.2 ± 12.5 years). Daytime mean systolic blood pressure (SBP) and diastolic blood pressure (DBP) and night-time mean SBP and DBP were significantly different in groups mmHg and 71 [55-87] mmHg; Group 2: 137 [107-188] mmHg and 83 [107-188] mmHg; Group 3: mmHg and 76 [55-124] mmHg), p < 0.001; respectively. MPV and RDW levels were different in all four groups (p < 0.001). We found a significant difference in the rates of stroke and coronary artery disease between the four groups (p = 0.018 and p = 0.002, respectively). In the ROC curve analysis MPV had sensitivity of %77. 8 and specificity of 78. 1% for stroke when the cut-off value MPV was 9.25 (Area under curve: 0.808, 95% confidence interval: 0.726-0.889, p < 0.001). Conclusions: In our study, MPV and RDW levels and the rates of stroke and cardiovascular disease were significantly higher in non-dipper patients compared to other groups.

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Section: Discussionsupporting

confidence: 54%

Is there a difference between normotensive and hypertensive patients in terms of blood parameters and cardiovascular diseases?

Aydın

Alpsoy

Engin

et al. 2021

The European Research Journal

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“…To support an inflammatory component in the process of vWF activation, several inflammatory cytokines, including tumor necrosis factor (TNF) -α, IL-8, and IL-6, stimulate the release of vWF from endothelial cells [12,13]. TNF-α and IL-6 are known to be the key inflammatory cytokines in RA, which may explain the correlation between vWF activity and RA.…”

Section: Discussionmentioning

confidence: 99%

“…Von Willebrand factor (vWF) is considered a reliable marker of endothelial dysfunction/damage, which is known to be an initial step in the development of atherosclerosis [11]. In addition, vWF has been confirmed to be associated with an increase in the carotid intima-media thickness (IMT) in asymptomatic subjects [12,13]. To date, there are only a few studies, the subject of which is vWF as a hypothetical marker of early atherosclerotic pathology in RA patients [14,15].…”

Section: Introductionmentioning

confidence: 99%

Von Willebrand Factor and Intima-Media Thickness in Patients With Rheumatoid Arthritis: A Cross-Sectional Study

Fedorovych

Yatsyshyn²

2023

Galician med. j.

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Background. Cardiovascular risk assessment in patients with rheumatoid arthritis (RA) is often a real challenge and requires the search for new indicators to reveal the potential threat of developing atherosclerotic vascular lesions in the early stages. The study aimed to analyse the association between von Willebrand factor (vWF), disease activity, and intima-media thickness (IMT) score in RA patients. Materials and Methods. The study involved 60 RA patients divided into three groups based on the Disease Activity Score 28 (DAS-28) activity index and 20 individuals as healthy controls. Clinical and laboratory assessments included determining the number of swollen (SJ) and painful joints (PJ), the visual analogue scale (VAS) score, the erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and fibrinogen. The concentration of vWF in blood plasma was determined by an enzyme-linked immunosorbent assay (ELISA). The IMT was measured at the bifurcation of the external and internal carotid arteries. Asymptomatic vascular damage was identified as the IMT > 0.9 mm; an atherosclerotic plaque was verified when a focal structure encroached ≥ 0.5 mm or 50% of the adjacent IMT value into the carotid lumen or the IMT > 1.5 mm. Results. Most RA patients (39/60; 65.0%) showed an increase in the IMT (> 0.9 mm); atherosclerotic plaques (IMT > 1.5 mm) were confirmed in 16 (26.7%) individuals, which was significantly more as compared to the control group. VWF was positively associated with the IMT [OR 1.1 (1.06-1.2), p < 0.001]. In addition, elevated levels of vWF were associated with disease activity. The highest values of vWF were found in patients with moderate RA activity (43.3 [21.2-56.9]). There was a positive correlation between vWF and ESR, CRP, DAS-28 (0.564, 0.455, and 0.573, respectively). Conclusions. There was a positive correlation between vWF, inflammatory markers, and disease activity. VWF appeared to be a reliable predictor of the IMT score in RA patients.

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“…As we know, platelet function per se is weaving to such an extent that it makes its usefulness as a disease biomarker for a chronic condition rather weak, as reported in available literature [ 55 ]. On the other hand, our findings demonstrate that certain circulating miRNAs are able to reflect the current clinical status of platelet inhibition (significant difference among ASA and clopidogrel) and prognostic power in our study population.…”

Section: Discussionmentioning

confidence: 99%

MiR-126 Is an Independent Predictor of Long-Term All-Cause Mortality in Patients with Type 2 Diabetes Mellitus

Pordzik

Eyileten-Postula

Jakubik

et al. 2021

JCM

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MicroRNAs are endogenous non-coding RNAs that are involved in numerous biological processes through regulation of gene expression. The aim of our study was to determine the ability of several miRNAs to predict mortality and response to antiplatelet treatment among T2DM patients. Two hundred fifty-two patients with diabetes were enrolled in the study. Among the patients included, 26 (10.3%) patients died within a median observation time of 5.9 years. The patients were receiving either acetylsalicylic acid (ASA) 75 mg (65%), ASA 150 mg (15%) or clopidogrel (19%). Plasma miR-126, miR-223, miR-125a-3p and Let-7e expressions were assessed by quantitative real time PCR and compared between the patients who survived and those who died. Adjusted Cox-regression analysis was used for prediction of mortality. Differential miRNA expression due to different antiplatelet treatment was analyzed. After including all miRNAs into one multivariate Cox regression model, only miR-126 was predictive of future occurrence of long-term all-cause death (HR = 5.82, 95% CI: 1.3–24.9; p = 0.024). Furthermore, miR-126, Let-7e and miR-223 expressions in the clopidogrel group were significantly higher than in the ASA group (p = 0.014; p = 0.013; p = 0.028, respectively). To conclude, miR-126 expression is a strong and independent predictor of long-term all-cause mortality among patients with T2DM. Moreover, miR-223, miR-126 and Let-7e present significant interactions with antiplatelet treatment regimens and clinical outcomes.

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Atherosclerosis, myocardial infarction and primary hemostasis: Impact of platelets, von Willebrand factor and soluble glycoprotein VI

Cited by 8 publications

References 48 publications

Is there a difference between normotensive and hypertensive patients in terms of blood parameters and cardiovascular diseases?

Is there a difference between normotensive and hypertensive patients in terms of blood parameters and cardiovascular diseases?

Von Willebrand Factor and Intima-Media Thickness in Patients With Rheumatoid Arthritis: A Cross-Sectional Study

MiR-126 Is an Independent Predictor of Long-Term All-Cause Mortality in Patients with Type 2 Diabetes Mellitus

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