Atherosclerosis of middle cerebral artery: Evaluation with high-resolution MR imaging at 3T

Li, Mingli; Xu, Wei-Hai; Song, Lan; Feng, Feng; You, Hui; Ni, Jun; Gao, Shan; Cui, Liying; Jin, Zhengyu

doi:10.1016/j.atherosclerosis.2008.10.019

Cited by 119 publications

(86 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3,[15][16][17]21,34,35 However, those studies lacked information regarding the comparison between luminal angiography and HR-MR, which may lead to disputes and confusion regarding the usefulness of HR-MR as an imaging method. Only a few studies have attempted to reveal the usefulness of HR-MR compared with DSA.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of High-Resolution MR Imaging and Digital Subtraction Angiography for the Characterization and Diagnosis of Intracranial Artery Disease

Lee

Chung

Jung

et al. 2016

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

“…[1][2][3] ICAD generally presents with intracranial artery stenosis on luminal evaluation, even though it includes various ICADs, such as atherosclerosis, dissection, Moyamoya disease, and vasculitis. The degree of stenosis has been the most common and important characteristic for evaluating ICAD and determining the treatment options.…”

mentioning

confidence: 99%

Comparison of High-Resolution MR Imaging and Digital Subtraction Angiography for the Characterization and Diagnosis of Intracranial Artery Disease

Lee

Chung

Jung

et al. 2016

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

show abstract

“…In the past decade, the technique of high-resolution magnetic resonance imaging (HRMRI) has been developed (5)(6)(7)(8). Emerging studies have suggested that HRMRI is reliable for detecting intracranial artery wall lesions, consistent with histology findings (7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

Etiology of intracranial stenosis in young patients: a high-resolution magnetic resonance imaging study

Gao

et al. 2017

Ann. Transl. Med.

Self Cite

View full text Add to dashboard Cite

Background: Using high-resolution magnetic resonance imaging (HRMRI), we sought to investigate the underlying etiology of intracranial stenosis in young patients. Methods:We retrospectively studied 122 Chinese young adult patients (from 18 to 45 years old, mean age 36.2±7.5 years) with unilateral middle cerebral artery (MCA) stenosis based on a prospectively established HRMRI database. The eccentricity, degree of stenosis, and remodeling types of MCA lesions were analyzed.The MCA lesions were classified as eccentric (presumed atherosclerosis) or concentric stenosis (presumed non-atherosclerosis). The clinical data and vessel wall properties were compared between the patients >35 years old and the patients ≤35 years old.Results: Eccentric stenosis was observed in 98 (80.3%) patients and concentric stenosis in 24 (19.7%) patients. The patients with eccentric stenosis were older (37.5±6.8 vs. 31.4±8.4 years old, P<0.001) and more likely had atherosclerosis risk factors (56.1% vs. 25.0%, P=0.006). The patients >35 years old had higher prevalence (90.1% vs. 66.7%, P=0.001) of eccentric stenosis and atherosclerosis factors (60.6% vs. 35.3%, P=0.006) than the patients ≤35 years old. Most of the patients with concentric stenosis were ≤35 years old (17/24, 70.8%) and were female (16/24, 66.7%). Binary Logistic analysis suggested smoking (OR =3.171; 95% CI,) and remodeling ratio (OR =1.625; 95% CI, 1.001-2.636) were independent predictive factors for symptomatic stenosis.Conclusions: Atherosclerosis is the most common cause of intracranial stenosis in Chinese young patients.Non-atherosclerosis disease is an important etiology in young female, especially in the patients aged 35 years old or younger.

show abstract

“…76 Most prior reports of high-resolution MR imaging of the MCA (summarized in Table 2) have focused on T2-weighted imaging findings within the arterial wall by using 3T scanners. 71,77 Figure 3A, -B exemplifies the focused use of highresolution T2-weighted sagittal imaging to resolve the plaque morphology following localization of a stenotic lesion on MRA. T2-weighted high-resolution MR imaging yielded moderate-to-good inter-and intraobserver reproducibility for detection of wall abnormalities and wall thickening.…”

Section: Plaque Characterizationmentioning

confidence: 99%

“…T2-weighted high-resolution MR imaging yielded moderate-to-good inter-and intraobserver reproducibility for detection of wall abnormalities and wall thickening. 77 Detection of plaque characteristics within the MCA has the potential to indicate whether plaque is at risk of rupture (eg, the plaque has a thinned or ruptured fibrous cap) or is stable (eg, it has a thick fibrous cap), assuming MCA atherosclerosis pathophysiology parallels that in the carotid artery. 78 A protective fibrous cap in MCA atherosclerosis appears as a bright band adjacent to the lumen on T2-weighted images.…”

Section: Plaque Characterizationmentioning

confidence: 99%

MR Angiography and Imaging for the Evaluation of Middle Cerebral Artery Atherosclerotic Disease

Degnan

Gallagher

Zhang

et al. 2011

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

SUMMARY:Intracranial atherosclerotic disease may constitute the most common cause of ischemic stroke worldwide; yet, in the developed world, imaging research has largely focused on extracranial atherosclerosis. Many studies in populations of Asian, African, and Hispanic descent demonstrate the preponderance of intracranial stenosis compared with carotid stenosis. This review examines the clinical presentations of MCA atherosclerosis and stenosis and the use of noninvasive MR imaging in the assessment of intracranial vasculature. MRA is a well-validated technique that offers great advantage over traditional angiography. Advances in high-resolution MR imaging of MCA stenosis have the potential to yield excellent visualization of plaque. Future developments in high-resolution MR imaging to depict intracranial atherosclerosis are explored in this review; these advances will guide endovascular therapy and the comparison of novel interventions.ABBREVIATIONS: TOF ϭ time-of-flight; TCD ϭ transcranial Doppler S troke is a common cause of morbidity and mortality, with cerebrovascular disease constituting the second most frequent cause of death worldwide.1 While the burden of cerebrovascular disease in the developing world is receiving greater attention, its importance is underestimated.2 Intracranial atherosclerotic disease is reaching greater clinical prominence as potentially the greatest contributor to the burden of cerebrovascular disease worldwide.3 Previously, atherosclerotic disease within intracranial vessels was not well-appreciated clinically, perhaps due to the inability to visualize the MCA noninvasively or the greater emphasis on the more easily imaged carotid arteries. In an early study of MCA syndromes, Lhermitte et al 4 alleged that "atherosclerotic thrombosis of MCA is probably a rare event and the primary cause . . . lies in the proximal ICA . . . for an almost inaccessible artery appears to be of little significance." Thus, early investigations established a precedent of emphasizing extracranial atherosclerosis at the expense of investigation of other manifestations of cerebrovascular disease.In examining only extracranial disease, investigators may be detecting only advanced atherosclerosis. Some argue that MCA disease may precede extracranial atherosclerosis; this sequence is suggested by the lack of substantial carotid stenosis in a group of patients with intracranial atherosclerosis, while nearly all those with extracranial stenosis also had concomitant intracranial stenosis.5 Therefore, detecting intracranial atherosclerosis may enable clinicians to intervene earlier.There is much controversy about the degree of MCA stenosis responsible for stroke, with some groups arguing that MCA stenosis is not important in the white population on the basis of a small TCD sonography study.6 Yet a host of postmortem and imaging studies implicate MCA atherosclerosis as a likely cause of stroke.7-9 Further investigation is necessary to evaluate the prevalence and importance of MCA disease as an etiology of ischemic...

show abstract

Atherosclerosis of middle cerebral artery: Evaluation with high-resolution MR imaging at 3T

Cited by 119 publications

References 15 publications

Comparison of High-Resolution MR Imaging and Digital Subtraction Angiography for the Characterization and Diagnosis of Intracranial Artery Disease

Comparison of High-Resolution MR Imaging and Digital Subtraction Angiography for the Characterization and Diagnosis of Intracranial Artery Disease

Etiology of intracranial stenosis in young patients: a high-resolution magnetic resonance imaging study

MR Angiography and Imaging for the Evaluation of Middle Cerebral Artery Atherosclerotic Disease

Contact Info

Product

Resources

About