Atherosclerosis of the Internal Mammary Artery

Kay, H. D.; Korns, Michael E.; Flemma, Robert J.; Tector, A. Joseph; Lepley, Derward

doi:10.1016/s0003-4975(10)63917-3

Cited by 151 publications

(55 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our in vitro study was carried out in segments of the internal mammary artery, which is less prone to atherosclerosis (15) and, by inference, may also be less susceptible to vascular dysfunction. However, the internal mammary artery is still a representative vessel, since its endothelium-dependent relaxation is blunted with high cholesterol concentrations (15) and in type 2 diabetes (16), when superoxide anion formation is also increased (7).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Nitric Oxide–Sensitive Soluble Guanylyl Cyclase Activity Is Preserved in Internal Mammary Artery of Type 2 Diabetic Patients

et al. 2004

View full text Add to dashboard Cite

Vascular reactivity to nitric oxide (NO) is mediated by NO-sensitive soluble guanylyl cyclase (sGC). Since a diminished activity of vascular sGC has been reported in an animal model of type 2 diabetes, the sGC activity was assayed in vitro in internal mammary artery specimens obtained during bypass surgery from patients with and without type 2 diabetes. The sensitivity of sGC to NO, which is dependent on Fe 2؉ -containing heme, was measured in vitro using stimulation with diethylamine NONOate (DEA/NO). In addition, the novel cyclic guanosine monophosphate-elevating compound HMR-1766 was used to test the stimulation of the oxidized heme-Fe 3؉ -containing form of sGC. Basal activity of sGC and its sensitivity to stimulation by DEA/NO and HMR-1766 were not different between control and type 2 diabetic patients: maximum stimulation by DEA/NO amounted to 475 ؎ 67 and 418 ؎ 59 pmol ⅐ mg ؊1 ⅐ min ؊1 in control and type 2 diabetic patients, respectively. The maximum effects of HMR-1766 were 95 ؎ 18 (control subjects) and 83 ؎ 11 pmol ⅐ mg ؊1 ⅐ min ؊1 (type 2 diabetic patients). Hypertension, hyperlipidemia, drug treatment with statins, ACE inhibitors, or nitrates had no effect on sGC activity. In conclusion, the present findings do not support the hypothesis that desensitization of sGC contributes to the pathogenesis of diabetic vascular dysfunction in humans. Diabetes 53

show abstract

Section: Discussionmentioning

confidence: 99%

“…However, the internal mammary artery is still a representative vessel, since its endothelium-dependent relaxation is blunted with high cholesterol concentrations (15) and in type 2 diabetes (16), when superoxide anion formation is also increased (7).…”

Section: Discussionmentioning

confidence: 99%

Nitric Oxide–Sensitive Soluble Guanylyl Cyclase Activity Is Preserved in Internal Mammary Artery of Type 2 Diabetic Patients

et al. 2004

View full text Add to dashboard Cite

show abstract

“…Because of the long patency rates and resistance to atherosclerosis, LITA is the preferred graft for surgical revascularization of the left anterior descending artery (LAD). 1,2 However, the presence of significant proximal left subclavian artery stenosis may result in reversal of LITA coronary graft flow and produce myocardial ischemia. Prevalence of significant stenosis of the subclavian artery in patients referred for coronary artery bypass graft (CABG) surgery was reported to be 0.2% to 6.8%.…”

Section: Introductionmentioning

confidence: 99%

Patent Coronary Artery Bypass Graft (CABG) is not Sufficient for Myocardial Perfusion - Non-ST Elevation Myocardial Infarction Caused by Critical Subclavian Artery Stenosis

Lee

Kim

Shin

et al. 2014

J Lipid Atheroscler

View full text Add to dashboard Cite

Myocardial revascularization using the left internal thoracic artery (LITA) has become a standard method for coronary artery bypass graft (CABG) surgery due to its long-term graft patency and lower repeated revascularization rate compared to a saphenous vein graft. The prevalence of significant subclavian artery stenosis was reported to be 0.2-6.8% in patients undergoing CABG surgery using LITA. We present a case of 49-year-old female patient who complained of resting chest pain and left arm pain after CABG surgery using the LITA. NSTEMI was caused by de novo subtotal left subclavian artery stenosis proximal to the LITA. The left subclavian artery was successfully stented, and the patient experienced complete relief of pain.

show abstract

“…Additionally, the relative immunity of the LITA to arteriosclerosis greatly contributes to this [3,4] as do specific factors of the vessel wall such as the histologic [5,6], ultrastructural [5] and histochemical [7,8] compositions.…”

Section: Introductionmentioning

confidence: 99%

<![CDATA[<B>Sequential histomorphometric study of the left internal thoracic artery</B>]]>

Kneubil¹,

Gomes²,

Aquino³

et al. 2006

Braz. j. cardiovasc. surg.

View full text Add to dashboard Cite

Objective: The use of left internal thoracic artery (LITA) in coronary artery bypass surgery is currently recognized as the best option, providing lower incidences of cardiovascular events and superior long-term survival. Now, incremental utilization of these grafts makes a reassessment of its histological structure necessary. Therefore, the purpose of this study was to examine and compare the sequential histological structure of LITA.Method: Specimens of LITA harvested from 18 cadavers, divided into nine proportional segments, were studied. Cuts of each segment were stained by the Verhoeff-Van Gieson technique. The following parameters were analyzed: perimeter of the arterial lumen, thickness of the intima, thickness of the media layer, amount of elastic fiber in the media layer and the elastic fiber density.Results: The collected data showed that perimeter of the LITA decreases downstream on its course, the thickness of the intima is increased in the proximal segments, the thickness of the media layer diminishes throughout its extension, the number of elastic fibers is concentrated in the intermediate segments and the density of elastic fibers is reduced in the proximal and distal segments. Conclusion:Therefore, the findings of the present study validate the heterogeneity of the LITA sequential histological structure. Descriptors

show abstract

Atherosclerosis of the Internal Mammary Artery

Cited by 151 publications

References 3 publications

Nitric Oxide–Sensitive Soluble Guanylyl Cyclase Activity Is Preserved in Internal Mammary Artery of Type 2 Diabetic Patients

Nitric Oxide–Sensitive Soluble Guanylyl Cyclase Activity Is Preserved in Internal Mammary Artery of Type 2 Diabetic Patients

Patent Coronary Artery Bypass Graft (CABG) is not Sufficient for Myocardial Perfusion - Non-ST Elevation Myocardial Infarction Caused by Critical Subclavian Artery Stenosis

<![CDATA[<B>Sequential histomorphometric study of the left internal thoracic artery</B>]]>

Contact Info

Product

Resources

About