Atherosclerosis progression affects the relationship between endothelial function and aortic stiffness

Kopeć, Grzegorz; Podolec, Piotr; Podolec, Jakub; Rubiś, Paweł; Żmudka, Krzysztof; Tracz, Wiesława

doi:10.1016/j.atherosclerosis.2008.09.003

Cited by 26 publications

(22 citation statements)

References 29 publications

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“…It is considered that the loss of elasticity of the walls of the arteries, especially the aorta is a marker of the early changes that may lead to the development of atherosclerosis and its following complications (eg, hypertension, stroke, myocardial infarction) in healthy individuals [1]. Increase in arterial stiffness was proven to be caused by several factors such as age, hypertension, hypercholesterolemia, diabetes, and smoking [2-5]. In the detection of early growth of the aortic wall stiffness pulse wave velocity (PWV) and/or augmentation index (AIx) are commonly used [6].…”

Section: Introductionmentioning

confidence: 99%

Arterial stiffness in adult patients after Fontan procedure

Tomkiewicz‐Pająk

Dziedzic-Oleksy

Pająk

et al. 2014

Cardiovasc Ultrasound

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ObjectivesIncreased arterial stiffness is a risk factor of atherosclerosis and cardio-vascular complications. The aim of the study was to determine whether peripheral vascular function might be an early marker of impaired health status in patients with a single ventricle after Fontan procedure.Methods and resultsTwenty five consecutive adults (11 women and 14 men) aged 24.7 ± 6.2 years after the Fontan procedure and 25 sex, age and BMI match healthy volunteers underwent physical examination, blood analysis, transthoracic echocardiography and noninvasive assessment of aortic stiffness. Augmented pressure and Augmentation Index (AIx) were both significantly elevated in Fontan when compared to the controls (6,08 ± 0,7 vs. 2,0 ± 3,7; p = 0.002 and 17,01 ± 3,3 vs. 6,05 ± 11; p < 0.001, respectively). There were no differences in pulse wave velocity (PWV), mean blood pressure (BP), brachial pulse pressure (PP), central: systolic BP, diastolic BP and PP. In Fontan group we find negative correlation between PWV and SatO2 (r = −0.68; p = 0.04) and positive correlation with WBC (0.72; p = 0.72; p = 0.013), INR (0.81; p = 0.008), TNFα (r = 0.45; p = 0.04), and postoperative time (r = 0.77; p = 0.02). AIx correlates positively only with age at surgery (r = 0.45; p = 0.04). Bilirubin level correlates positively with brachial PP (r = 0.71; p = 0.02) and central PP (r = 0.68; p = 0.03).The multivariate model showed that SatO2 (β = −0.44, p = 0.04) was the only independent predictor of PWV (R2 = 0.32, p = 0.03).ConclusionAdult Fontan patients have an increased arterial stiffness assessed by a noninvasive technique. Low arterial oxygen saturation postoperative time, age at surgery, white blood cells, TNFα and bilirubin level are associated with arterial stiffening in these patients. The combination of blood parameters of the hepatic function and noninvasive measurements of arterial stiffness could be helpful in comprehensive care of patients with Fontan circulation.

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Section: Introductionmentioning

confidence: 99%

Arterial stiffness in adult patients after Fontan procedure

Tomkiewicz‐Pająk

Dziedzic-Oleksy

Pająk

et al. 2014

Cardiovasc Ultrasound

Self Cite

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“…Kobayashi et al found a significant correlation of FMD with brachial-ankle PWV 22) . Interestingly, the significance was abolished after adjusting for age, BP, and IMT in all subjects, but remained in subjects younger than 70 yr. Kopeć et al found a significant relationship between FMD and PWV in subjects without coronary artery stenosis, but not in subjects with coronary artery stenosis 28) . Witte et al investigated whether FMD was affected by arterial stiffness, and found that the relationship of FMD with age and current smoking, which were used as proxies for the relation between FMD and true endothelial function, became less pronounced according to increasing arterial stiffness 29) .…”

Section: Fmd and Pwvmentioning

confidence: 99%

Flow-Mediated Dilation is Associated with Microalbuminuria Independent of Cardiovascular Risk Factors in Type 2 Diabetes

Yokoyama

Sone

Saito

et al. 2011

JAT

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“…5,6,61,62,64 However, it is important to note that FMD has been previously shown to be significantly associated with arterial stiffness under a number of conditions and disease states. [122][123][124][125][126] Wright et al 127 noted that this association was weak and suggested that measurements of arterial stiffness should not replace FMD. However, they used neither AIx nor cfPWV (the 'gold standard') as arterial stiffness measurements in their study.…”

Section: Mechanismsmentioning

confidence: 99%

The effect of smoking on arterial stiffness

et al. 2010

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A systematic literature review was conducted using PubMed, Embase and the Cochrane Library to determine the effect of acute, chronic and passive smoking on arterial stiffness and to determine whether these effects are reversible after smoking cessation. A total of 39 relevant studies were identified and included. Acute smoking was found to cause an acute increase in arterial stiffness. Similarly, passive smoking increased arterial stiffness acutely and chronically. The majority of studies identified chronic smoking as a risk factor for increasing arterial stiffness. However, some studies found no statistical difference in arterial stiffness between nonsmokers and long-term smokers, although chronic smoking seems to sensitize the arterial response to acute smoking. In addition, whether arterial stiffness is reversed after smoking cessation and the timeline in which this may occur could not be determined from the identified literature. The effect of smoking discontinuation on arterial stiffness remains to be established by prospective smoking cessation trials.

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Atherosclerosis progression affects the relationship between endothelial function and aortic stiffness

Cited by 26 publications

References 29 publications

Arterial stiffness in adult patients after Fontan procedure

Arterial stiffness in adult patients after Fontan procedure

Flow-Mediated Dilation is Associated with Microalbuminuria Independent of Cardiovascular Risk Factors in Type 2 Diabetes

The effect of smoking on arterial stiffness

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