Atherosclerosis Studies by Intracoronary Ultrasound

Gotsman, Mervyn S.; Mosseri, Morris; Rozenman, Yoseph; Admon, Dan; Lotan, Chaim; Nassar, Hisham

doi:10.1007/978-1-4615-5959-7_17

Cited by 9 publications

(3 citation statements)

References 39 publications

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“…If 80% or more of the plaque area is more echogenic than the adventitia and the arc of calcium is < 90°, it is characterized as mixed. If there is an arc of calcium with acoustic shadowing > 90°of the vessel wall circumference, the plaque is considered to be calcified [9], [14•], [15,16]. VH-IVUS has been demonstrated to relatively accurately identify soft, mixed, and calcified plaque, as well as identify plaque composition.…”

Section: Background Surrounding Coronary Plaque Imagingmentioning

confidence: 99%

Coronary Artery CT Angiography for Plaque Imaging

Chrysant

2010

Curr Cardiovasc Imaging Rep

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Cardiac CT is becoming a mainstream and integral part of many cardiology practices based on a vast base of literature supporting and validating its clinical utility. As the technology continues to advance, coronary imaging has improved in stride. In the next several years, cardiac CT may become the "gatekeeper" of cardiac testing, surpassing the more common and widespread nuclear testing as the initial strategy in evaluating ischemia. Unfortunately, in spite of an arsenal of tests available to detect clinically significant stable coronary artery disease, many people continue to suffer acute myocardial infarction and other acute coronary syndromes, leading to significant morbidity and mortality due to unstable coronary artery disease. These unstable, "vulnerable" plaques continue to plague cardiologists across the globe. The ability to identify vulnerable plaque is a step in the right direction toward therapy. It is in this particular arena that advancements in cardiac CT technology may bear the most fruit. A growing body of evidence supporting the utility of cardiac CT in plaque imaging has emerged and has demonstrated that potentially unstable coronary artery disease is able to be identified accurately and noninvasively.

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Section: Background Surrounding Coronary Plaque Imagingmentioning

confidence: 99%

Coronary Artery CT Angiography for Plaque Imaging

Chrysant

2010

Curr Cardiovasc Imaging Rep

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“…Conventional angiography (CA) is considered the diagnostic standard for determining the presence of coronary artery stenosis [1]. However, this technique bears risks because it is invasive which leads to moderate mortality and morbidity, and it also has limitations because it only provides information on the lumen of the coronary artery but not about the wall or the plaque itself [5,10,14,15,20,21].…”

Section: Ct Angiography Of the Coronary Arteriesmentioning

confidence: 99%

General Utilities of Multislice Tomography in the Cardiac Field

Carrascosa

Capuñay

Parodi

et al. 2003

Herz

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“…Mixed, or intermediate, as >80% plaque area echoes as bright or brighter than adventitia, but without acoustic shadows. Calcified, as bright, echoes with acoustic shadowing accompanying >90% of the vessel wall circumference [6,7]. The addition of radiofrequency backscatter analysis enabled more detailed assessment of noncalcified plaque components.…”

Section: Introductionmentioning

confidence: 99%

Insights from CTA with Comparison to Modalities of Intravascular Ultrasound Imaging

Burke

Budoff

2011

Curr Cardiovasc Imaging Rep

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Noninvasive imaging of atherosclerosis by cardiac CT continues to rapidly evolve. A large collection of data has emerged on detection and quantification of coronary plaque in vivo with cardiac CT with comparison to the gold standard of clinical plaque assessment, intravascular ultrasound. Given inherent spatial limitations, although the correlation is significant, the variability and limits of agreement of these measurements are wide. More recently, focus has shifted to detecting plaque stability, or rather high-risk features of plaque, and identifying those "vulnerable" to rupture. This is a concept originated in histopathology and translated clinically into invasive plaque characterization through virtual histology, or IVUS-VH. We will review the literature regarding methods of plaque assessment, as well as plaque progression and outcomes data, in cardiac CT with regard to its correlation with IVUS and IVUS-VH. The potential in cardiac CT lies within the noninvasive detection of coronary artery disease, its ability to help distinguish those plaques and thus, those patients most vulnerable, which ultimately may be utilized for risk stratification, direction of aggressive therapy, and even as a way to evaluate effects of medical therapies.

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Atherosclerosis Studies by Intracoronary Ultrasound

Cited by 9 publications

References 39 publications

Coronary Artery CT Angiography for Plaque Imaging

Coronary Artery CT Angiography for Plaque Imaging

General Utilities of Multislice Tomography in the Cardiac Field

Insights from CTA with Comparison to Modalities of Intravascular Ultrasound Imaging

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