2002
DOI: 10.1253/circj.66.173
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Atherosclerotic Plaque Characterization by Quantitative Analysis Using Intravascular Ultrasound

Abstract: acrophages and lymphocytes play a prominent role in atherosclerotic plaque formation, progression and rupture, which are responsible for the majority of acute coronary syndromes. [1][2][3][4][5] Macrophages also play a pivotal role in the restenosis process following coronary intervention. 6,7 Therefore, the real-time evaluation in vivo of infiltrated atherosclerotic plaque is of prime importance.Intravascular ultrasound (IVUS), which provides realtime in vivo tomographic images, is a useful technique for eval… Show more

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Cited by 22 publications
(23 citation statements)
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“…33 Okimoto et al reported that atherosclerotic plaque morphology, as defined by quantitative analysis of IVUS images, was related to the immunohistochemical findings. 34 In the present study, the RI was significantly higher in the elevated CRP group, which indicates that a highly inflammatory state as expressed by elevated CRP is associated with vascular remodeling and NIH.…”
Section: Discussionsupporting
confidence: 57%
“…33 Okimoto et al reported that atherosclerotic plaque morphology, as defined by quantitative analysis of IVUS images, was related to the immunohistochemical findings. 34 In the present study, the RI was significantly higher in the elevated CRP group, which indicates that a highly inflammatory state as expressed by elevated CRP is associated with vascular remodeling and NIH.…”
Section: Discussionsupporting
confidence: 57%
“…Fourth, we arbitrarily defined plaque of less than 200 m (not 100 m) as vulnerable because (1) yellow plaque is frequently detected in patients with acute coronary syndrome whereas white plaque is frequently detected in patients with stable angina pectoris (reference no. A), (2) the fibrous cap of yellow plaque is so thin (<75 m) that we can see the yellow lipid core (reference no. B), and (3) the fibrous cap of white plaque is too thick (>200 m) to visualize the lipid core.…”
Section: Study Limitationsmentioning
confidence: 98%
“…2,3 It is well known that the degree of coronary stenosis is not related to the likelihood of myocardial infarction, and that pre-infarction coronary stenosis is found in less than 75% of the patients with myocardial infarction. 4 Acute coronary syndromes and acute cerebral infarction are caused in most cases by plaque rupture, and therefore, it is particularly important to assess the stability of the plaque.…”
mentioning
confidence: 99%
“…Recent studies have shown that ACS result from rupture of the fibrous cap of an atheromatous plaque, exposing the lumen to the lipid-rich atheromatous plaque core and leading to sudden thrombus formation. [21][22][23] Inflammatory markers of coronary risk, such as hs-CRP, cytokines (IL-1, IL-6, etc), TNF-, vascular-cell adhesion molecule 1, and intercellular adhesion molecule 1, have been used to evaluate the vulnerability of atheromatous plaques and to predict the risk of ACS. Such inflammatory markers are expected to contribute to the identification of patients at increased risk for ACS.…”
Section: Discussionmentioning
confidence: 99%