Atherosclerotic plaques induced by marble-burying behavior are stabilized by exercise training in experimental atherosclerosis

Abstract

Behavioral stress increased the atherosclerotic lesions and induced the adhesion molecule expression with superoxide production on the lesions in apo E-deficient mice. Exercise training may stabilize plaque lesions induced by marble-burying behavior in this animal model.

Irisin protects macrophages from oxidized low density lipoprotein-induced apoptosis by inhibiting the endoplasmic reticulum stress pathway

“…The above inferences need to be confirmed in vivo . In arteriosclerotic mice with apolipoprotein E knockout, exercises can stabilize plaques by reducing macrophage infiltration, oxidative stress, inflammatory factors and matrix metalloproteinase expression (Shimada et al, 2011, Kadoglou et al, 2013). As exercises can enhance the synthesis of irisin, it mediates the effect of exercises on the alleviation of obesity and other metabolic disorders, but whether irisin stabilizes plaques by exercises needs to be further studied.…”

Aerobic exercise and not a diet supplemented with jussara açaí (Euterpe edulisMartius) alters hepatic oxidative and inflammatory biomarkers in ApoE-deficient mice

“…The exercise-induced expression of NO synthase ( 54 ) may contribute to the reduction of atherosclerotic lesion number as its inhibition accelerates atherosclerosis, although it was not assessed in the present study. Furthermore, exercise training has been reported to reduce atherosclerotic lesion number without changing blood lipid profile in ApoE − / − mice ( 52 ) . We observed that the levels of serum total cholesterol and TAG have little or no influence on fat deposition in the coronary arteries of patients with severe atherosclerosis, which may help to explain the reduction of atherosclerotic lesion number by factors other than decreased total cholesterol levels, including reduced inflammation, endothelial dysfunction and oxidative stress ( 55 ) .…”

Vascular Adaptation to Exercise in Humans: Role of Hemodynamic Stimuli

“…Recent animal studies suggest that exercise training is associated with stabilisation of atherosclerotic plaque and increased content of collagen and elastin (273). In a retrospective analysis in humans, higher physical fitness levels were associated with high fibrous volume and thick fibrous cap thickness of coronary plaques (324).…”