Athetosis-dystonia in intramedullary lesions of spinal cord

Madhusudanan, M; Gracykutty, M; Cherian, Mathew

doi:10.1111/j.1600-0404.1995.tb00134.x

Cited by 19 publications

(5 citation statements)

References 8 publications

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“…In the literature, mostly in the form of case studies, movement disorders due to cervical cord lesions were also reported in syringomyelia (16), traumatic cervical spinal cord damage (12,17), cervical cord tumor (18) in addition to demyelinating diseases. The demyelination plaques on the cervical spinal cord in the three MS cases presented here suggested that the dystonias may likely be due to the damage of the somatosensory pathways of the spinal cord.…”

Section: Discussionmentioning

confidence: 99%

Focal Hand Dystonia as a Sign of Demyelinating Attack in Multipl Sclerosis: 'Report of Three Cases’

Öcek¹,

Köşkderelioğlu²,

Gücüyener³

et al. 2014

tnd

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Re cei ved/Ge lifl Ta ri hi: 28.09.2013 Ac cep ted/Ka bul Ta ri hi: 06.02.2014 Although it is known that dystonia is a basal ganglia disease, dystonic symptoms have been observed in association with lesions of various sites located in sensory and motor pathways. We report three cases of paroxysmal focal hand dystonia, which may be due to the damage of the somatosensorial pathways in the cervical spinal cord. We suggest that the dystonia in our patients may be related to these active demyelinating cervical plaques. Two female and one male patients with definite relapsing remitting Multiple sclerosis (MS) between the ages of 22 to 45 were admitted with serious disability while using their right hands. In all three cases abnormal posture in the right hand and involuntary sustained contractions together with minor choreiform movements of the fingers were observed. Cervical MRI showed contrast-enhancing demyelinating lesions at the level of C2-3 in all patients. One of the patient's cranial MRI revealed also two new contrast-enhancing plaques on the neighbourhood of right posterior lateral ventricle and parietal cortex. No new or enhancing lesion was detected in the basal ganglia; indicating that the cervical spinal cord lesions were responsible for hand dystonia. In one of the patients, the right median somatosensory evoked potential response was absent in accordance with the clinical symptom. All three patients were treated with 1 gr. intravenous methylprednisolone per day for 5-10 days. Approximately one month later, clinical symptoms have been completely disappeared and control cervical MRI revealed resolution of the active lesions in all.

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Section: Discussionmentioning

confidence: 99%

Focal Hand Dystonia as a Sign of Demyelinating Attack in Multipl Sclerosis: 'Report of Three Cases’

Öcek¹,

Köşkderelioğlu²,

Gücüyener³

et al. 2014

tnd

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“…In 1994, a report was published detailing a 14 year old boy presenting with torticollis secondary to a spinal astrocytoma [41]. In 1995, Madhusudanan reported a patient with dystonia and athetosis due to a spinal glioma [42]. One report from 2006 highlighted five pediatric cases of cervical spine tumors leading to torticollis.…”

Section: Dystonia Secondary To Non-demyelinating Spinal Lesionsmentioning

confidence: 99%

“…Syringomyelia has also been highlighted as a cause of spinal dystonia. In 1995, Madhusudanan et al reported two patients who developed dystonia and athetosis as a result of syringomyelia [42]. In 1999, Hill et al reported two additional patients suffering from movement disorders secondary to syringomyelia.…”

Section: Dystonia Secondary To Non-demyelinating Spinal Lesionsmentioning

confidence: 99%

Spinal dystonia and other spinal movement disorders

Sarin

Lawal²,

Abboud

2023

Dystonia

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While traditionally considered a disorder of the basal ganglia, brainstem, and cerebellum, multiple reports have shown that spinal cord pathologies may lead to dystonia. In this article, we first discuss various spinal movement disorders and the differences between tonic spasms, spinal dystonia, spinal myoclonus, spinal tremors, and paroxysmal dyskinesia. We review potential pathogenesis of spinal dystonia. We then focus on reports of dystonia secondary to spinal cord demyelinating diseases such as multiple sclerosis and neuromyelitis optica spectrum disorders. We conclude by discussing the potential treatment options for spinal dystonia.

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“…The association of syringomyelia with dystonia has been infrequently reported in the medical literature. Since its first description in 1983, 14 definite cases have been described . We report on 4 further cases of dystonia associated with syringomyelia (Fig.…”

mentioning

confidence: 93%

Syringomyelia‐Associated Dystonia: Case Series, Literature Review, and Novel Insights

Mulroy

Balint

Latorre

et al. 2019

Movement Disord Clin Pract

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BackgroundBackground: Syringomyelia has previously been suggested as a potential trigger of secondary dystonia. However, a definite causal relationship between the conditions remains to be established. We describe 4 cases of syrinx-associated dystonia, review past literature on the subject, and propose novel pathophysiological insights into this association. Methods Methods: We reviewed demographic, clinical, and neuroradiological features in 4 cases of syrinx-associated dystonia. A retrospective review of previously published literature on the subject was also conducted. ResultsResults: Patients with syrinx-associated dystonia were younger than those with primary dystonia. None had sensory gestes. Syringomyelia frequently involved the cervical cord. Arnold-Chiari type 1 malformation was a common finding. Some patients responded to botulinum toxin and syrinx decompression. Conclusion Conclusion: Further work is needed to clearly establish the correlation between syringomyelia and dystonia. However, plausibly, syrinx-related disruption of the dystonia network (through alterations in sensory inputs, loss of inhibition and cerebellar abnormalities) could explain the association.

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Athetosis-dystonia in intramedullary lesions of spinal cord

Cited by 19 publications

References 8 publications

Focal Hand Dystonia as a Sign of Demyelinating Attack in Multipl Sclerosis: 'Report of Three Cases’

Focal Hand Dystonia as a Sign of Demyelinating Attack in Multipl Sclerosis: 'Report of Three Cases’

Spinal dystonia and other spinal movement disorders

Syringomyelia‐Associated Dystonia: Case Series, Literature Review, and Novel Insights

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