Athlete's heart

Milutinović, Katarina; Stojiljković, Stanimir; Ćuk, Jelena; Lasica, Ratko; Miosavljević, Andrej; Cvetković, Dimitrije; Trajković, Aleksandra; Pešić, Vesna; Arena, Ros; Popović, Dejana

doi:10.5937/fizkul1802139m

Cited by 3 publications

(4 citation statements)

References 36 publications

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“…Meanwhile, exercise can lead to the alleviation of numerous cardiovascular symptoms, improvement of exercise capacity and quality of life, and decrease in disability, hospitalization, and mortality. 1) Although exercise exhibited cardioprotection against cardiac hypertrophy, especially the associated cardiac dysfunction, the molecular mechanisms of exercise-mediated cardioprotection have not been clearly elucidated. To sustain proper cardiac function during an individual's entire lifespan and to protect cardiac fitness and health, conserving and/or improving controllable damage against intracellular disorder caused by pressure overload is a significant factor in terms of the characteristics of cardiomyocytes.…”

mentioning

confidence: 99%

Role of Exercise on Alleviating Pressure Overload-Induced Left Ventricular Dysfunction and Remodeling <i>via</i> AMPK-Dependent Autophagy Activation

Gao

et al. 2020

Int. Heart J.

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Cardiac hypertrophy is one of the significant risk factors that result in maladaptive cardiac remodeling and heart failure, and exercise is known to exert cardioprotection. In this research, the cardioprotective function and exercise mechanisms were explored. The rats underwent transverse aortic constriction (TAC) or a sham operation. The rats that received TAC were randomly assigned to five groups: (1) rats subjected to a sham operation as control group (SC), (2) rats that underwent TAC group (TC), (3) TAC and moderate-intensity exercise group (TE), (4) TE plus 3-MA group (TEM), and (5) TE plus Compound C group (TEC). The heart function was measured via echocardiography. Histological analysis and relative protein testing were conducted to analyze collagen deposition and apoptosis. Furthermore, western blot was employed to measure the protein expression of relevant signaling pathways. Impaired cardiac function, interstitial fibrosis, enhanced apoptosis, and ER stress were observed in the TACinduced left ventricular hypertrophy. Exercise attenuated TAC-induced cardiac dysfunction, interstitial fibrosis, and ER stress-related apoptosis. In addition, exercise significantly improved autophagy and upregulated AMPK phosphorylation. Furthermore, AMPK inhibitor Compound C repressed the activation of AMPK, and autophagy inhibitor 3-methyladenine reversed exercise-induced autophagy. All of these abolished the protection of exercise against cardiac dysfunction and fibrosis induced by TAC. Our results indicated that 4 weeks of treadmill exercise could alleviate pressure overload-induced LV dysfunction and remodeling via an autophagy-dependent mechanism, which was induced by enhancing autophagy through the activation of AMPK.

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mentioning

confidence: 99%

Role of Exercise on Alleviating Pressure Overload-Induced Left Ventricular Dysfunction and Remodeling <i>via</i> AMPK-Dependent Autophagy Activation

Gao

et al. 2020

Int. Heart J.

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“…Greater morphological and less functional changes of the right ventricle to the left ventricle in athletes may be attributed to greater resistance in the lung in comparison to systemic circulation (Milutinović et al, 2018). The intensity of morphological changes increases with training intensity (ibid.).…”

Section: Discussionmentioning

confidence: 99%

“…All non-physiological stimuli in the training process (overtraining, dehydration, doping, etc. ), further complicate these mechanisms and can very easily turn them in a pathological direction, with potentially fatal consequences (Milutinović et al, 2018;Vanova et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Морфолошке И Функционалне Катактеристике Десног Срца Код Елитних Триатлонаца Из Србије

Papić,

Ristanović,

Ranisavljev

et al. 2023

TEME

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Many research papers show that the most intense cardiac remodelling can be seen in endurance athletes, but no studies have examined right heart remodelling in triathletes. The aim of the study is to examine the morphological and functional characteristics of the right heart in elite Serbian triathletes. To assess the morpho-functional characteristics of the right heart, cardiac ultrasounds were performed following current recommendations, using a Philips IE33 device and a 5.2-MHz probe. The right ventricular diameter (RVEDD) was measured from the parasternal cross-section, and the right atrial volume (RAvol) and the right ventricular wall thickness (RVWT) were measured from the four-cavity cross-section. The M-mode method was used to measure the amplitude of the movement of the right ventricular tricuspid annulus (TAPSE). The sample consisted of two groups of men: experimental – elite triathlete seniors from Serbia (n=17; age: 35.88±11.27), and control – healthy untrained adults (n=20; age: 21.35±2.08). RVEDD, RAvol, and RVWT were significantly higher in the experimental group compared to the control group (p<0.01), but no significant difference was observed in TAPSE (p=0.653). Also, RVEDD and RAvol in the experimental group showed values higher than the reference values for the general population, while RVWT and TAPSE were within reference values. The obtained results indicate that there are signs of right heart remodeling in triathletes. Considering the growing number of persons involved in triathlon, it is necessary to draw the attention of all coaches and athletes to the importance of regularly monitoring the triathletes’ hearts.

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“…Exercise training imparts significant cardiovascular health benefits by improving aerobic fitness and quality of life and by decreasing disability, hospitalization, and mortality attributable to cardiovascular diseases. 1 Increasing evidence has demonstrated that exercise training has cardiovascular benefits, attracts more attention from clinicians, and is recommended as a non-drug therapy. 2 The American Heart Association includes physical activity as one of its “Life's Simple 7” metrics, 3 and recommends that adults perform at least 150−300 min/week of moderate-intensity physical activity or 75−150 min/week of vigorous-intensity physical activity.…”

Section: Introductionmentioning

confidence: 99%

Exercise training attenuates angiotensin II-induced cardiac fibrosis by reducing POU2F1 expression

Feng

Wang

et al. 2023

Journal of Sport and Health Science

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Athlete's heart

Cited by 3 publications

References 36 publications

Role of Exercise on Alleviating Pressure Overload-Induced Left Ventricular Dysfunction and Remodeling <i>via</i> AMPK-Dependent Autophagy Activation

Role of Exercise on Alleviating Pressure Overload-Induced Left Ventricular Dysfunction and Remodeling <i>via</i> AMPK-Dependent Autophagy Activation

Морфолошке И Функционалне Катактеристике Десног Срца Код Елитних Триатлонаца Из Србије

Exercise training attenuates angiotensin II-induced cardiac fibrosis by reducing POU2F1 expression

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