ATIVIDADE ANTI-EMBRIOGENICA "ÍN VITRO" DO ALBENDAZOL SOBRE OVOS DE Lagochilascaris minor Leiper,1909

Vieira, Marcelo Fernandes; Oliveira, Jayrson Araújo de; Barbosa, Carlos Augusto Lopes; Campos, Dulcinéia Maria Barbosa

doi:10.5216/rpt.v23i2.20026

Cited by 2 publications

(3 citation statements)

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“…Therefore, more studies are needed on the anthelmintic activity in the different stages of the parasite. For example, albendazole has been tested in vitro in suspension at a dose of 400 mg/10 ml of 1% formalin solution on newly eliminated eggs and embryonated eggs 37 . These authors found that, at this dosage, the drug prevents egg embryogenesis but has no effect on embryonated eggs, so its activity is restricted to embryogenesis, and there is no effect on larvae 37 .…”

Section: Discussionmentioning

confidence: 99%

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EVALUATION OF THE THERAPEUTIC EFFICACY OF LEVAMISOLE HYDROCHLORIDE ON THIRD-STAGE LARVAE OF Lagochilascaris minor IN EXPERIMENTALLY INFECTED MICE

Campos

Barbosa

Oliveira

et al. 2016

Rev. Inst. Med. trop. S. Paulo

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Lagochilascariosis, a disease caused by Lagochilascaris minor, affects the neck, sinuses, tonsils, lungs, the sacral region, dental alveoli, eyeballs and the central nervous system of humans. A cycle of autoinfection may occur in human host tissues characterized by the presence of eggs, larvae and adult worms. This peculiarity of the cycle hinders therapy, since there are no drugs that exhibit ovicidal, larvicidal and vermicidal activity. Given these facts, we studied the action of levamisole hydrochloride on third-stage larvae in the migration phase (G1) and on encysted larvae (G3) of L. minor. To this end, 87 inbred mice of the C57BL/6 strain were divided into test groups comprising 67 animals (G1-37; G3-30) and a control group (G2-10; G4-10) with 20 animals. Each animal was inoculated orally with 2,000 infective eggs of the parasite. The animals of the test groups were treated individually with a single oral dose of levamisole hydrochloride at a concentration of 0.075 mg. The drug was administered either 30 minutes prior to the parasite inoculation (G1 animals) or 120 days after the inoculation (G3 animals). The mice in the control groups were not treated with the drug. After the time required for the migration and the encysting of L. minor larvae, all the animals were euthanized and their tissues examined. The data were analyzed using the Student's unpaired t-test and the Levene test. The groups showed no statistically significant difference. Levamisole hydrochloride was ineffective on third-stage larvae of L. minor. These findings explain the massive expulsion of live adult worms, as well as the use of long treatment schemes, owing to the persistence of larvae and eggs in human parasitic lesions.

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Section: Discussionmentioning

confidence: 99%

“…Among the drugs tested experimentally, only albendazole prevents egg embryogenesis 37 . Ivermectin used at a higher than recommended dosage and levamisole hydrochloride have no activity against encysted larvae.…”

Section: Discussionmentioning

confidence: 99%

EVALUATION OF THE THERAPEUTIC EFFICACY OF LEVAMISOLE HYDROCHLORIDE ON THIRD-STAGE LARVAE OF Lagochilascaris minor IN EXPERIMENTALLY INFECTED MICE

Campos

Barbosa

Oliveira

et al. 2016

Rev. Inst. Med. trop. S. Paulo

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“…Vieira et ai. (14), usando o albendazol na mesma dosagem (400mg/kg), por 30 dias consecutivos, sobre ovos embrionados e ovos não embrionados (in vitró), verificaram que a droga impedia a embriogênese dos ovos.…”

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Avaliação Da Eficácia Do Albendazol Na Lagochilascaríase Murina Experimental

Vieira¹,

Oliveira²,

Barbosa³

2007

Rev Patol Trop

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Para avaliar a ação do albendazol sobre larvas de terceiro estágio de Lagochilascarís minor foram empregados 60 camundongos isogênicos C57BL/6, divididos cm três grupos iguais. Cada animal foi inoculado com l O3 ovos ínfectantes de L. minor, via oral, através de uma sonda esofagiana. Todos os animais dos Grupos I e H foram tratados individualmente com albendazol, na dosagem de 400mg/kg/dia, via oral, durante 30 dias. Tendo em vista o padrão de migração de larvas de L. minor no organismo de camundongo (hospedeiro intermediário), os animais do Grupo I receberam a droga a partir do 7° dia e os do Grupo II, no 60° dia após a inoculação. Os camundongos do Grupo III (controle) n3o foram tratados com a droga. No 5° dia após o término do uso da droga, todos os animais de cada grupo foram necropsiados. O número de larvas vivas recuperadas dos nódulos da musculatura esquelética do tecido celular subcutâneo e das vísceras foi o critério utilizado para avaliar a eficácia da droga. Foram observados níveis de eficácia de 80,9% para o Grupo I e de 66,3% para o Grupo II. Podemos inferir que ambos os esquemas terapêuticos utilizados neste trabalho foram ineficazes no tratamento da lagochilascaríase murina experimental.

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ATIVIDADE ANTI-EMBRIOGENICA "ÍN VITRO" DO ALBENDAZOL SOBRE OVOS DE Lagochilascaris minor Leiper,1909

Cited by 2 publications

References 3 publications

EVALUATION OF THE THERAPEUTIC EFFICACY OF LEVAMISOLE HYDROCHLORIDE ON THIRD-STAGE LARVAE OF Lagochilascaris minor IN EXPERIMENTALLY INFECTED MICE

EVALUATION OF THE THERAPEUTIC EFFICACY OF LEVAMISOLE HYDROCHLORIDE ON THIRD-STAGE LARVAE OF Lagochilascaris minor IN EXPERIMENTALLY INFECTED MICE

Avaliação Da Eficácia Do Albendazol Na Lagochilascaríase Murina Experimental

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