Atividade anti-retroviral e propriedades farmacocinéticas da associação entre lamivudina e zidovudina

Souza, Jacqueline de; Storpirtis, Sílvia

doi:10.1590/s1516-93322004000100004

Cited by 10 publications

(12 citation statements)

References 37 publications

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“…Now the effects of antiretroviral Indinavir were evaluated in a study on pregnant test subjects, which showed that, according to the dose of the drug, the epatocytes showed heterocromados cores, and some fatty infiltration, congestion of the sinusoids and portal swelling (11) . All the inhibitors of reverse transcriptase nucleoside analogues (abacavir, didanosine, lamivudine, stavudine and zidovudine) cross the human placenta, reaching levels similar to those observed in umbilical cord and maternal blood at first reach the liver parenchyma (12) . From the observations of the aforementioned study and others (13)(14)(15) , the review of autopsies of abortions from HIV positive mothers became important research with respect to antiretroviral therapy in these patients and its implications in the analysis of factors related to vertical transmission, and emphasize the effectiveness of certain interventions to decrease of the incidence of vertical transmission, such as maternal antiretroviral therapy in breastfeeding populations and early cessation of breastfeeding (15)(16)(17) .…”

Section: Introductionmentioning

confidence: 72%

“…The detection by immunohistochemistry is jeopardized when the protein expression is low or when the protein is exported from the cell quickly. Other authors (4,(11)(12)(13) highlight the importance of assessing the necropsies of abortions from HIV-positive mothers in the research related to antiretroviral therapy in these patients, their implications and in the analysis of factors related to vertical transmission. Of the five cases of abortions examined, two were from mothers treated with zidovudine.…”

Section: Discussionmentioning

confidence: 99%

“…Other liver functions consist in the storage of vitamins (A, B 12 , D, E and K), and minerals (iron and copper) and in the regulation of blood volume, having significant antitoxic action against harmful substances to the organism, such as caffeine and alcohol, and in the processing of drugs (2,3) . The liver tissue, in theory, is not an organ by which the human immunodeficiency virus (HIV) has a predilection, as have for other organs and cells, however, in the early stage of HIV infection, the epatocytes are infected and become reservoirs of the virus, allowing its dissemination, with consequent development of acquired immunodeficiency syndrome (AIDS).…”

Section: Introductionmentioning

confidence: 99%

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Hepatic cHanges in abortions and infants from HiV-positiVe motHers

Oliveira¹,

Nascimento²,

Cardoso³

et al. 2013

J Bras Doenças Sex Transm

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Introduction:There are a few works in the literature concerning pathological and anatomical alterations of hepatic lesions in necropsies of aborts, stillbirths and children from HIV-positive mothers. Objective: To report pathological and anathomical hepatic alterations in fetus and infants from HIV-positive mothers, correlating them with HIV infections, etiologic agents of opportunistic infections and drugs used in different treatments. Methods: necropsy material from 15 children and 5 aborts was obtained from the Department of Pathology, Hospital Universitário Antônio Pedro, Fluminense Federal University, from 1986 to 2007. Aborts, stillbirths and children definitions followed World Health Organization criteria. Macro-and microscopic studies were performed after parafin inclusion with hematoxilin-eosin and other methods (periodic acid-Shiff, reticulin, Gomory's trichrome, silver methenamine, and Sudan stains). All necropsies were completed. Results: Results showed macroscopic changes in 13 cases, at least in one category, and microscopic changes compatible with esteatosis in 12 cases, necrosis in 7 cases, and colestasis in 4 children and stillbirths. Out of five abortions, two were due to mothers using zidovudina. All patients showed opportunistic infection. Conclusion: Macroscopic and microscopic hepatic changes are important in these patients and may not be related to the high frequency of the opportunistic infections. This study will provide subsidies for understanding the pathogenesis of hepatic problems caused by HIV virus, opportunistic agents and drugs used in therapy. Keywords: HIV, opportunistic infections, antiretroviral treatment, hepatic changes, infants. RESUMOIntrodução: São poucos os trabalhos relacionados à investigação das alterações anatomopatológicas das lesões hepáticas em necropsias de abortos, natimortos e crianças procedentes de mães HIV positivas. Objetivo: Descrever as alterações hepáticas em fetos e lactentes procedentes de mães HIV positivas, sob o ponto de vista anatomopatológico, correlacionando-as ao HIV, aos agentes etiológicos causadores de infecções oportunistas e às drogas utilizadas nos diferentes esquemas terapêuticos. Métodos: O material utilizado foi proveniente de 15 necropsias de crianças e 5 abortos realizadas pelo Serviço de Anatomia Patológica do Hospital Universitário Antônio Pedro, da Universidade Federal Fluminense, no período de 1986 a 2007. As definições de aborto e lactentes seguem os critérios adotados pela Organização Mundial da Saúde. Foram realizados estudos macroscópicos e microscópicos de fígado, após inclusão em parafina utilizando os corantes hematoxilina e eosina e outros métodos de coloração especial (ácido periódico de Schiff, reticulina, trinômio de Gomory, prata metanamina e Sudan). As necropsias foram completas. Resultados: Foram observadas alterações macroscópicas em 13 casos, em pelo menos um critério, alterações microscópicas compatíveis com esteatose foram observadas em 12, necrose em 7 e colestase em 4 das crianças e natimortos. Dos ci...

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Section: Introductionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hepatic cHanges in abortions and infants from HiV-positiVe motHers

Oliveira¹,

Nascimento²,

Cardoso³

et al. 2013

J Bras Doenças Sex Transm

View full text Add to dashboard Cite

show abstract

“…Relacionando os resultados laboratoriais com as associações antirretrovirais usadas pelos pacientes em estudo, verificou-se que, como os agentes antirretrovirais mais utilizados foram 3TC e AZT, sendo que o AZT foi relatado como tóxico apenas para células mielócitos e eritródes e a 3TC em geral apresenta baixa toxicidade 30,31 , é improvável a indução de efeitos adversos hepáticos e hematológicos, confirmando os resultados obtidos entre esse autor e a presente pesquisa.…”

Section: Discussionunclassified

“…Além disso, a comprovada eficácia desse medicamento a longo prazo e menor toxicidade faz com que ele seja uma das melhores opções terapêutica, o que concordou com os resultados obtidos 11,31 .…”

Section: Discussionunclassified