Atividade antifúngica de Caryocar brasiliensis (Caryocaraceae) sobre Cryptococcus neoformans

Abstract

The widespread occurrence of cryptococcosis mainly in immunocompromised patients and the side effects of available drugs which are effective against this mycosis have led investigators to search for new antimycotic agents. Caryocar brasiliensis derived compounds were investigated against Cryptococcus neoformans using the agar dilution method. Based on MIC values, the best results were obtained with a concentration of < 250 g/mL of cuticular waxes of the Caryocar brasiliensis leaf collected during the dry period (170.8mm of precipitation) which inhibited the growth of 91.3% (21/23) Cryptococcus neoformans isolates.

Leishmanicidal, antibacterial, and antioxidant activities of Caryocar brasiliense Cambess leaves hydroethanolic extract

“…Leaves infusion has been used for liver disorders (Siqueira, 1982). Molluscicidal activity of the crude extract against Biomphalaria glabrata , trypanosomicidal activity of the ethanol extract against Trypanosoma cruzi (Herzog-Soares, 2002) and antifungal activity of the oil (Passos et al, 2002) have also been reported. Its oleanolic acid has shown ability to inhibit the growth of mouse sarcoma 180 (Oliveira et al, 1970).…”

Cryptococcosis: a review of the brazilian experience for the disease

“…PASSOS et al 68 have studied "in vitro" the antifungal activity of a plant extract against the yeast. Meningeal cryptococcosis-associated AIDS treatment is done in two phases: the first one in the acute or induction phase, for six to 10 weeks or until CFS becomes sterile.…”

Diversidade de angiospermas e espécies medicinais de uma área de Cerrado

“…A planta toda é depurativa, anti-diarréica, purificadora, anti-reumática e para diminuir o colesterol do sangue (Pavan et al, 2009). …”

“…Bolsa-de-pastor A casca da raiz é utilizada para tratar afecções da pele e a casca do caule é antissifilítica (Rodrigues & Carvalho, 2001 (Passos et al, 2002).…”