Atl

Tanizaki, Yuko; Kobayashi, Aya; Shiro, Michihisa; Ota, Nakao; Takano, Rei; Mabuchi, Yasushi; Yagi, Shusuke; Minami, Sawako; Tomita, Masaki; Ino, Kazuhiko

doi:10.1097/igc.0000000000000074

Cited by 86 publications

(17 citation statements)

References 26 publications

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“…MRI, measurement of tumor markers (such as SCC and CA19-9) [15], and FDG-PET [16] may be useful for differentiating benign MCT from malignant transformation.…”

Section: Discussionmentioning

confidence: 99%

Trichoepithelioma Arising in an Ovarian Mature Cystic Teratoma

Suzuki

Nakayama

Muto

et al. 2016

Case Reports in Obstetrics and Gynecology

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Here, we report an extremely rare case of trichoepithelioma (TE)—a benign epithelial tumor originating from the outer root sheath of a hair follicle—arising in an ovarian mature cystic teratoma (MCT) with fluorodeoxyglucose-positron emission tomography (FDG-PET) findings. A 48-year-old Japanese woman presented to our hospital for her annual follow-up of adenomyosis. Ultrasonography and magnetic resonance imaging revealed a left ovarian tumor with irregular-shaped septum, which was suspicious of malignancy. However, tumor marker levels were within normal range. On FDG-PET, the maximum standardized uptake value (SUVmax) of the tumor was 2.9. Laparotomy with left salpingooophorectomy was performed. Pathologic examination revealed the probability of TE, rather than basal cell carcinoma (BCC), arising in an ovarian MCT. After five years of follow-up, the patient had no sign of recurrence. The FDG-PET SUVmax was low in TE, as with other benign tumor. However, future investigation is needed to evaluate the findings of FDG-PET imaging in TE cases.

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“…MRI, measurement of tumor markers (such as SCC and CA19-9) [15], and FDG-PET [16] may be useful for differentiating benign MCT from malignant transformation.…”

Section: Discussionmentioning

confidence: 99%

Trichoepithelioma Arising in an Ovarian Mature Cystic Teratoma

Suzuki

Nakayama

Muto

et al. 2016

Case Reports in Obstetrics and Gynecology

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“…PET studies were performed with a PET scanner (SET-3000BCT/L; Shimadzu, Kyoto, Japan) with an axial resolution of 3.9 mm and a 20 cm field of view, as described in our previous study (8). At the time of the tracer injection, all patients had fasted for at least 5 h and had blood glucose levels <150 mg/dl.…”

Section: Fdg-pet/ct and Imaging Analysismentioning

confidence: 99%

“…18 F-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET) with computed tomography (CT) is a well-established imaging modality for diagnosing and staging numerous types of cancer. In gynecological malignancies, previous studies revealed that the maximum standardized uptake value (SUV max ), a quantitative measurement of the tissue deoxyglucose metabolic rate measured on FDG-PET/CT, may be a useful parameter, not only for evaluating malignancy, but also for assessing the prognosis of patients with ovarian (7,8) and cervical cancer (9,10). In endometrial neoplasms, several previous reports demonstrated the usefulness of SUV max for preoperative risk stratification (11,12), although its prognostic impact remains controversial (13)(14)(15)(16), and it remains to be sufficiently studied in patients with uterine carcinosarcoma.…”

Section: Introductionmentioning

confidence: 99%

Prognostic impact of primary tumor SUVmax on preoperative 18F-fluoro-2-deoxy-D-glucose positron emission tomography and computed tomography in endometrial cancer and uterine carcinosarcoma

Yahata

Yagi

Mabuchi

et al. 2016

Molecular and Clinical Oncology

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Abstract. The objective of the present study was to investigate the usefulness of the maximum standardized uptake value (SUV max ) of the primary tumor on preoperative 18 F-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography and computed tomography (PET/CT) as a prognostic indicator in patients with endometrial neoplasms. A total of 75 patients with endometrial cancer or uterine carcinosarcoma who underwent surgical treatment were included in the present study. All patients underwent preoperative PET/CT, and the correlation between the SUV max of the primary tumor and clinical outcomes was analyzed. The SUV max was significantly higher in patients with stage II/ III disease, a histology of grade 3 endometrioid adenocarcinoma and carcinosarcoma, a positive lymph node (LN) status, positive lymph-vascular space involvement (LVSI), and deep (≥1/2) myometrial invasion. Receiver operating characteristic curve analysis revealed that the optimal cut-off values of SUV max for predicting a positive LN, LVSI and deep myometrial invasion were 7.49, 6.45 and 6.45, respectively. The overall survival (OS) and progression-free survival (PFS) of patients with a high SUV max were significantly lower compared with those of patients with a low SUV max using the cut-off value of 7.30. However, no significant difference was observed in the OS or PFS between the high and low SUV max groups when analyzed in carcinosarcoma patients alone. Finally, multivariate analyses demonstrated that the SUV max of the primary tumor was an independent prognostic factor for impaired PFS in 55 endometrioid adenocarcinoma patients; however, not in all patients, including those with carcinosarcoma. The present findings demonstrated that the SUV max of the primary tumor may be a useful biomarker for predicting clinical outcomes of patients with endometrial cancer, although its prognostic impact appears to be limited in patients with uterine carcinosarcoma.

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“…Positron emission tomography studies were performed with a PET scanner (SET-3000BCT/L; Shimadzu, Kyoto, Japan) with an axial resolution of 3.9 mm and a 20-cm field of view, as described in our previous study (12). At the time of the tracer injection, all the patients had fasted for ≥5 h and had blood glucose levels <150 mg/dl.…”

Section: Fdg-pet/ct and Imaging Analysismentioning

confidence: 99%

“…Previous studies have shown that the maximum standardized uptake value (SUV max ), a semiquantitative simplified measurement of the tissue deoxyglucose metabolic rate measured on FDG-PET/CT, could be a parameter for evaluating malignancy and for assessing the prognosis of patients with ovarian cancer (11,12) and endometrial cancer (13)(14)(15). Therefore, the use of SUV max as a new biomarker that is easily measureable on PET/CT prior to the start of treatment in patients with gynecological malignancies has received considerable attention.…”

Section: Introductionmentioning

confidence: 99%

Primary tumor SUVmax on preoperative FDG-PET/CT is a prognostic indicator in stage IA2-IIB cervical cancer patients treated with radical hysterectomy

Yagi

Yahata

Mabuchi

et al. 2016

Molecular and Clinical Oncology

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Abstract. The objective of the present study was to investigate the prognostic value of 18 F-fluoro-2-deoxy-D-glucose (FDG) uptake by primary tumors on positron emission tomography/computed tomography (PET/CT) in surgically resectable cervical cancer. A total of 59 patients with stage IA2-IIB cervical cancer who underwent preoperative FDG-PET/CT, followed by radical hysterectomy and lymphadenectomy, were included in the study. The maximum standardized uptake value (SUV max ) of the primary tumor was measured, and the association between the SUV max and clinicopathological factors or patient outcomes was analyzed. The SUV max was significantly higher in patients with an advanced stage, lymph node metastasis, lymph-vascular space involvement and large tumors. The overall survival (OS) and progression-free survival (PFS) of patients with a high SUV max were significantly lower compared with patients with a low SUV max , using an optimal cut-off value of 7.36 for OS and 5.59 for PFS obtained from receiver operating characteristic curve analysis. Similarly, OS and PFS in patients with a high SUV max were significantly lower in 39 patients with stage IB using a cut-off value of 7.90 and 6.69 for OS and PFS, respectively. Finally, multivariate analyses showed that the SUV max of the primary tumor was an independent prognostic factor for impaired PFS in all patients and those with stage IB alone. These findings demonstrated that a high SUV max on preoperative PET/CT was correlated with unfavorable clinical outcomes in patients receiving radical hysterectomy, suggesting that the SUV max of the primary tumor may be a prognostic indicator for surgically-treated, early-stage invasive cervical cancer.

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Atl

Cited by 86 publications

References 26 publications

Trichoepithelioma Arising in an Ovarian Mature Cystic Teratoma

Trichoepithelioma Arising in an Ovarian Mature Cystic Teratoma

Prognostic impact of primary tumor SUVmax on preoperative 18F-fluoro-2-deoxy-D-glucose positron emission tomography and computed tomography in endometrial cancer and uterine carcinosarcoma

Primary tumor SUVmax on preoperative FDG-PET/CT is a prognostic indicator in stage IA2-IIB cervical cancer patients treated with radical hysterectomy

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