Atlas of Liver Pathology 2nd edition

Kanel, Gary C.; Korula, Jacob; Renshaw, Andrew A.

doi:10.1097/01.pap.0000184172.91468.cd

Cited by 11 publications

(42 citation statements)

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“…Liver cell adenoma was rare before the era of oral contraceptives [27]. At present, the incidence has increased but is still low: 3-4 /100 000 per year in long-term users of oral contraception [27][28][29]. The patients mostly are 20-39 years old.…”

Section: Liver Cell Adenoma and Its Differential Diagnosis With Focalmentioning

confidence: 99%

Section: Liver Cell Adenoma and Its Differential Diagnosis With Focalmentioning

confidence: 99%

“…The epidemiology is characterised by female predominance (90%) and strong association with oral contraceptive use [26][27] as 85% of affected persons have such history. Liver cell adenoma was rare before the era of oral contraceptives [27]. At present, the incidence has increased but is still low: 3-4 /100 000 per year in long-term users of oral contraception [27][28][29].…”

Section: Liver Cell Adenoma and Its Differential Diagnosis With Focalmentioning

confidence: 99%

“…Abdominal fullness can be attributed to the presence of mass lesion; pain can be caused by necrosis [27]. Rupture and bleeding (40%) represent dangerous complications [27,[29][30][31]; the risk of these events is increased in pregnant ladies affected by liver cell adenoma due to prior use of hormonal contraceptives. Risk of malignant transformation also is recognised [29,32].…”

Section: Liver Cell Adenoma and Its Differential Diagnosis With Focalmentioning

confidence: 99%

“…The tumours can be quite large (5-20 cm). In most cases (75%) adenomas are encapsulated [27]. However, the capsule can be thin or absent [10].…”

Section: Liver Cell Adenoma and Its Differential Diagnosis With Focalmentioning

confidence: 99%

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Primary and Metastatic Tumours of the Liver: Expanding Scope of Morphological and Immunohistochemical Details in the Biopsy

Štrumfa¹,

Vilmanis²,

Vanags³

et al. 2012

Liver Biopsy - Indications, Procedures, Results

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Section: Liver Cell Adenoma and Its Differential Diagnosis With Focalmentioning

confidence: 99%

Section: Liver Cell Adenoma and Its Differential Diagnosis With Focalmentioning

confidence: 99%

Section: Liver Cell Adenoma and Its Differential Diagnosis With Focalmentioning

confidence: 99%

Section: Liver Cell Adenoma and Its Differential Diagnosis With Focalmentioning

confidence: 99%

“…The tumours can be quite large (5-20 cm). In most cases (75%) adenomas are encapsulated [27]. However, the capsule can be thin or absent [10].…”

Section: Liver Cell Adenoma and Its Differential Diagnosis With Focalmentioning

confidence: 99%

See 3 more Smart Citations

Primary and Metastatic Tumours of the Liver: Expanding Scope of Morphological and Immunohistochemical Details in the Biopsy

Štrumfa¹,

Vilmanis²,

Vanags³

et al. 2012

Liver Biopsy - Indications, Procedures, Results

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PI3K/Akt activation is critical for early hepatic regeneration after partial hepatectomy

Jackson

Larson

Silva

et al. 2008

American Journal of Physiology-Gastrointestinal and Liver Physi

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Hepatic resection is associated with rapid proliferation and regeneration of the remnant liver. Phosphatidylinositol 3-kinase (PI3K), composed of a p85alpha regulatory and a p110alpha catalytic subunit, participates in multiple cellular processes, including cell growth and survival; however, the role of PI3K in liver regeneration has not been clearly delineated. In this study, we used the potent PI3K inhibitor wortmannin and small interfering RNA (siRNA) targeting the p85alpha and p110alpha subunits to determine whether total or selective PI3K inhibition would abrogate the proliferative response of the liver after partial hepatectomy in mice. Hepatic resection is associated with an induction in PI3K activity; total PI3K blockade with wortmannin and selective inhibition of p85alpha or p110alpha with siRNA resulted in a significant decrease in hepatocyte proliferation, especially at the earliest time points. Fewer macrophages and Kupffer cells were present in the regenerating liver of mice treated with wortmannin or siRNA to p85alpha or p110alpha, as reflected by a paucity of F4/80-positive cells. Additionally, PI3K inhibition led to an aberrant architecture in the regenerating hepatocytes characterized by vacuolization, lipid deposition, and glycogen accumulation; these changes were not noted in the sham livers. Our data demonstrate that PI3K/Akt pathway activation plays a critical role in the early regenerative response of the liver after resection; inhibition of this pathway markedly abrogates the normal hepatic regenerative response, most likely by inhibiting macrophage infiltration and cytokine elaboration and thus hepatocyte priming for replication.

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Proliferative and Nonproliferative Lesions of the Rat and Mouse Hepatobiliary System

Thoolen¹,

Maronpot

Harada³

et al. 2010

Toxicol Pathol

519

433

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The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internationally-accepted nomenclature for proliferative and non-proliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature and differential diagnosis for classifying microscopic lesions observed in the hepatobiliary system of laboratory rats and mice, with color microphotographs illustrating examples of some lesions. The standardized nomenclature presented in this document is also available for society members electronically on the internet (http://goreni.org). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous and aging lesions as well as lesions induced by exposure to test materials. A widely accepted and utilized international harmonization of nomenclature for lesions of the hepatobiliary system in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.

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Atlas of Liver Pathology 2nd edition

Cited by 11 publications

References 0 publications

Primary and Metastatic Tumours of the Liver: Expanding Scope of Morphological and Immunohistochemical Details in the Biopsy

Primary and Metastatic Tumours of the Liver: Expanding Scope of Morphological and Immunohistochemical Details in the Biopsy

PI3K/Akt activation is critical for early hepatic regeneration after partial hepatectomy

Proliferative and Nonproliferative Lesions of the Rat and Mouse Hepatobiliary System

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