This dissertation describes the first measurement of three-body photodisintegration of polarized 3 He (γ 3 He → npp) with a circularly polarized photon beam. This measurement was carried out at the High Intensity γ-Ray Source(HIγS) facility located at Duke University Free Electron Laser Laboratory and the incident photon energy was 11.4 MeV. A high-pressure polarized 3 He target based on spin exchange optical pumping (SEOP) of hybrid alkali was employed. Two methods-Nuclear Magnetic Resonance (NMR) and Electron Paramagnetic Resonance (EPR)-were used to measure the polarization, which was determined to be ∼ 42%. The data from the experiment were analyzed and a GEANT4 simulation was carried out to determine the corrections for finite geometry, neutron multiple scattering and detector efficiencies used in this experiment. The results are compared to the state-of-the-art three-body calculations and agreements are observed within rather large statistical uncertainties of the measurement. This experiment represents the first measurement of the asymmetry using spin-dependent 3 He photodisintegration. The unpolarized differential cross section and helicity-dependent differential cross-section difference results are also presented and compared to the same theoretical calculations followed by a discussion of the results. Total cross section is also extracted using two different methods and agrees well with the theoretical prediction. New developments including a Sol-Gel coated pyrex 3 He cell since the experiment iv are then presented. The in-beam test results of the aforementioned target cell from May 2009 test run are included and the prospect of future three-body photodisintegration is discussed in the end. v To my parents Qingchao Xiao and Youxin Zong, also to Jidi Liu.