Atlas of Regional Left Ventricular Scar in Nonischemic Cardiomyopathies

Del Franco, Annamaria; Ruggieri, Roberta; Pieroni, Maurizio; Ciabatti, Michele; Zocchi, Chiara; Biagioni, Giulia; Tavanti, Valentina; Del Pace, Stefano; Leone, Ornella; Favale, Stefano; Guaricci, Andrea Igoren; Udelson, James; Olivotto, Iacopo

doi:10.1016/j.jacadv.2024.101214

JACC: Advances

2024

DOI: 10.1016/j.jacadv.2024.101214

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Atlas of Regional Left Ventricular Scar in Nonischemic Cardiomyopathies

Annamaria Del Franco,

Roberta Ruggieri,

Maurizio Pieroni

et al.

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Overcoming Resistance in Anderson–Fabry Disease: Current Therapeutic Challenges and Future Perspectives

Carella,

Forleo,

Caretto

et al. 2024

JCM

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Anderson–Fabry disease (AFD) remains a therapeutic challenge despite advances in early diagnosis and the availability of enzyme replacement therapies (ERTs). While early initiation of therapy can mitigate disease progression, resistance mechanisms—such as the development of anti-drug antibodies—limit the efficacy of current treatments, particularly in patients with severe genetic variants. Chaperone therapy provides a targeted option for a subset of patients, yet significant gaps remain in treating those with complete enzyme deficiency. This perspective article explores the existing therapeutic landscape and reflects on emerging treatments, such as mRNA and gene therapies, which hold promise for overcoming the resistance mechanisms. By addressing the limitations of current pharmacological options and considering future innovations, this article aims to outline the path forward for more effective and personalized treatment strategies in Anderson–Fabry disease.

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Overcoming Resistance in Anderson–Fabry Disease: Current Therapeutic Challenges and Future Perspectives

Carella,

Forleo,

Caretto

et al. 2024

JCM

View full text Add to dashboard Cite

show abstract

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Atlas of Regional Left Ventricular Scar in Nonischemic Cardiomyopathies

Cited by 1 publication

References 68 publications

Overcoming Resistance in Anderson–Fabry Disease: Current Therapeutic Challenges and Future Perspectives

Overcoming Resistance in Anderson–Fabry Disease: Current Therapeutic Challenges and Future Perspectives

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