Atm sequence variants are predictive of adverse radiotherapy response among patients treated for prostate cancer

Late rectal toxicity after prostate brachytherapy: Influence of supplemental external beam radiation on dose–volume histogram analysis

“…As outlined in the prior studies, one planning goal for patients in this study was to minimize rectal V 100 (median, 0.05 cc) by avoiding seed placement very close to the prostateerectal interface. As prostate brachytherapy technique continues to improve, doseevolume relationships may become increasingly difficult to describe and may rely more heavily on patient-specific biologic factors (13).…”

Urinary Symptom Flare in 712 125I Prostate Brachytherapy Patients: Long-Term Follow-Up

“…Although this could be a truly incidental finding, it is possible that a true association exists between multiple organ toxicities and a patient's ability to repair the radiation-induced DNA damage. Whether genetic variants in DNA repair genes coding for different individual radiosensitivities might be responsible for the increase in toxicity after PB remains a subject of research (18)(19)(20)(21).…”

Longitudinal Analysis of Genitourinary and Bowel Symptoms in Prostate Cancer Patients Following Brachytherapy

“…68 -71 Cesaretti et al examined the impact of ATM sequence variants among patients treated for prostate cancer and found that 10 of 16 (63%) patients with ATM sequence alterations had an adverse response to brachytherapy, whereas only 3 of 21 (14%) without ATM alterations had brachytherapy-related adverse effects. 72 Hall et al noted that 3 of 17 prostate cancer patients with radiation-related morbidity had ATM mutations. 73 Mathematical models that incorporate clinical/demographic information about patients known before treatment, along with genetic information related to radiation injury repair may provide more accurate patient-level predictions for brachytherapy-related outcomes.…”