2016
DOI: 10.1016/j.cub.2016.01.011
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AtMic60 Is Involved in Plant Mitochondria Lipid Trafficking and Is Part of a Large Complex

Abstract: The mitochondrion is an organelle originating from an endosymbiotic event and playing a role in several fundamental processes such as energy production, metabolite syntheses, and programmed cell death. This organelle is delineated by two membranes whose synthesis requires an extensive exchange of phospholipids with other cellular organelles such as endoplasmic reticulum (ER) and vacuolar membranes in yeast. These transfers of phospholipids are thought to occur by a non-vesicular pathway at contact sites betwee… Show more

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Cited by 88 publications
(125 citation statements)
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“…In addition, the MICOS complex shows genetic interactions in yeast with components of the ERMES complex and consequently, a role of the MICOS complex in lipid trafficking from ER to the IM of mitochondria has been proposed [66]. This hypothesis is supported by a recent study in plants showing the involvement of Mic60 in mitochondria lipid trafficking (see below) [8].…”
Section: Traffic Between the Om And Im Of Mitochondriamentioning
confidence: 87%
See 1 more Smart Citation
“…In addition, the MICOS complex shows genetic interactions in yeast with components of the ERMES complex and consequently, a role of the MICOS complex in lipid trafficking from ER to the IM of mitochondria has been proposed [66]. This hypothesis is supported by a recent study in plants showing the involvement of Mic60 in mitochondria lipid trafficking (see below) [8].…”
Section: Traffic Between the Om And Im Of Mitochondriamentioning
confidence: 87%
“…The quantity of AtMic60 and Tom40 increases in the MTL complex during Pi starvation similar to the content of DGDG suggesting that the MTL complex, via AtMic60 and OM partners such as Tom40, could mediate the traffic of DGDG in mitochondria during Pi starvation . In addition, some proteins, of unknown functions, that localize to the outer envelope of plastids have been characterized as components of the MTL complex . These proteins are putative candidates to mediate membrane tethering and/or lipid trafficking between mitochondria and plastids.…”
Section: Mitochondria Glycerolipid Trafficking In Plantsmentioning
confidence: 99%
“…Under this condition, the cellular content of DGDG and SQDG is increased, and DGDG is distributed to other organelles (Fig. ; Haertel et al , Jouhet et al , Moellering & Benning , Michaud et al ). This is accompanied with enhanced expression of genes coding for atMGD2 and atMGD3 (Fig.…”
Section: Discussionmentioning
confidence: 97%
“…In addition, morphological changes have been observed for some organelles. Under high light conditions, peroxisomes produce tubular protrusions, called peroxules, that extend over the surface of the chloroplast and mitochondria (Jouhet et al, 2004;Michaud et al, 2016). Stromules, dynamic extensions of the chloroplast stroma, have been observed to be associated with the nucleus and the plasma membrane (Kwok & Hanson, 2004;Caplan et al, 2015).…”
Section: Stromules: Chloroplast-nucleus Communication During Plant Immentioning
confidence: 99%
“…Connections between the chloroplast envelope and the ER membrane are observed following the trans-organellar complementation of a mutant that is defective in tocopherol biogenesis (Mehrshahi et al, 2013). During phosphate starvation, translocation of digalactosylglycerol (DGDG) lipids synthesized in the plastids to the mitochondrial membranes at mitochondria-plastid contact sites has been shown using transmission electron microscopy and biochemical approaches (Jouhet et al, 2004;Michaud et al, 2016). Under high light stress conditions, peroxisomes also produce tubular structures, called peroxules, that extend to the chloroplast and mitochondrial surface (Oikawa et al, 2015;Jaipargas et al, 2016).…”
Section: Conclusion and Prospectsmentioning
confidence: 99%