A novel methodology based on the host−guest interactions operating at the immiscible interfaces was developed for the extraction of Au and Ag nanoparticles (NPs) as model nanopollutants from aqueous bulk by using water-insoluble surface active iron oxide NPs. Extraction was driven by the host−guest interactions operating at the air−water interface between the Gemini surfactants and cyclodextrin (CD) molecules immobilized on magnetic and Au/Ag NPs, respectively. The efficiency of the extraction process was monitored with the help of UV−visible and DLS studies and quantitatively analyzed by using TEM, FESEM, and XPS studies of the extracted complex consisting of magnetic and Au/Ag NPs. Fe/Au or Fe/Ag high mole ratio successfully accomplished the extraction that further relied on the molecular architecture of Gemini surfactants as well as the cavity size of CD molecules. Steric constraints induced by the long hydrocarbon chain and spacer groups of Gemini surfactants impeded the extraction. The cavity size of β-CD was the most appropriate for successful extraction in comparison to that of αand γ-CD. To depict the sustainability, magnetic NPs were easily separated from the extracted complex to obtain pure Au/Ag NPs and reuse the magnetic NPs.