Atmospheric plasma sprayed silica–hydroxyapatite coatings on magnesium alloy substrates

Bogya, Erzsébet Sára; Károly, Zoltán; Barabáş, Réka

doi:10.1016/j.ceramint.2015.01.041

Cited by 56 publications

(30 citation statements)

References 53 publications

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“…In order to acquire a more reliable coating of HA on the surface of PET and to minimize the potential toxicity caused by chemical residue of biochemical reagents, the plasma spraying technique was introduced in this study. Materials modified using the plasma spraying technique have been investigated by several studies 19,20 and have been proved to improve cell proliferation on these materials. In this technique, HA nanoparticles were carried by heated plasma beam and precipitated onto substrates.…”

Section: Introductionmentioning

confidence: 99%

Enhance the biocompatibility and osseointegration of polyethylene terephthalate ligament by plasma spraying with hydroxyapatite in vitro and in vivo

Wang¹,

Ge²,

Ai³

et al. 2018

IJN

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PurposeThis study was designed to evaluate the biocompatibility and osseointegration of polyethylene terephthalate ligament after coating with hydroxyapatite (PET/HA) by using the plasma spraying technique in vitro and in vivo.MethodsIn this study, PET/HA sheets were prepared by using the plasma spraying technique. The characterization, the viability of bone marrow stromal cells (BMSCs), and the mRNA expression of bone formation-related genes were evaluated in vitro. The osseointegration in vivo was investigated in the rabbit anterior cruciate ligament (ACL) reconstruction model by micro-computed tomography (micro-CT) analysis, histological evaluation, and biomechanical tests.ResultsScanning electron microscopy (SEM) results showed that the surface of polyethylene terephthalate (PET) becomes rough after spraying with hydroxyapatite (HA) nanoparticles, and the water contact angle was 75.4°±10.4° in the PET/HA-plasma group compared to 105.3°±10.9° in the control group (p<0.05). The cell counting kit-8 counting results showed that the number of BMSCs significantly increased in the PET/HA-plasma group (p<0.05). Reverse transcription polymerase chain reaction (RT-PCR) results showed that there was an upregulated mRNA expression of bone formation-related genes in the PET/HA-plasma group (p<0.05). Micro-CT results showed that the transactional area of tibial tunnels and femoral tunnels was smaller in the PET/HA-plasma group (p<0.05). The histological evaluation scores of the PET/HA-plasma group were significantly superior to those of the PET control group at 8 and 12 weeks (p<0.05). The biomechanical tests showed an increased maximum load to failure and stiffness in the PET/HA-plasma group compared to those in the control group at 8 and 12 weeks.ConclusionBoth in vitro and in vivo results demonstrated in this study suggest that the biocompatibility and osseointegration of PET/HA ligament were significantly improved by increasing the proliferation of cells and upregulating the expression of bone formation-related genes. In a word, the PET/HA-plasma ligament is a promising candidate for ACL reconstruction in future.

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Section: Introductionmentioning

confidence: 99%

Enhance the biocompatibility and osseointegration of polyethylene terephthalate ligament by plasma spraying with hydroxyapatite in vitro and in vivo

Wang¹,

Ge²,

Ai³

et al. 2018

IJN

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“…The present study considers two levels of surface modification: Chemical methods, such as coatings, and physical modifications. Coatings such as inorganic Ca-P (Liu, Hu, Ding, & Wang, 2011;Xu et al, 2009), hydroxyapatite (Ashuri, Moztarzadeh, Nezafati, Ansari Hamedani, & Tahriri, 2012;Bogya, Károly, & Barabás, 2015;Li'nan, Chenghao, Naibao, Feng, & Lixia, 2015), and organic polymers (Li, Cao, Zhang, Zhang, & He, 2010;Wong et al, 2010) serve as an additional barrier between the environment and the implant (Gray & Luan, 2002). The barrier reduces the risk of contamination with foreign metals and may result in the generation of additional properties that can reduce the risk of biofilm formation and promote the healing process.…”

Section: Engineering Characteristicsmentioning

confidence: 99%

Development of magnesium implants by application of conjoint‐based quality function deployment

Siefen

Höck

2019

J Biomedical Materials Res

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Biodegradable magnesium‐based implants are the subject of a great deal of research for different orthopedic and vascular applications. The targeted design and properties depend on the specific medical function and location in the body. Development of the biomaterial requires a comprehensive understanding of the biological interaction between the implant and the host tissue, as well as of the behavior in the physiological environment in vivo. Research into and the development of innovative magnesium implants entails interdisciplinary research efforts and communication between materials science, bioscience, and medical experts. The present study provides a transparent planning and communication tool for market‐oriented implant development processes. The objective was to identify medical needs at an early stage of the development process and to quantify the importance of the engineering characteristics of different research fields that cater to specific implant requirements. The method is demonstrated by the performance of a survey‐based conjoint analysis, which was integrated into a quality function deployment approach. Twenty‐seven medical professionals and 29 biomaterial scientists assessed the importance of identified medical requirements, whereby the control of mechanical integrity and degradation along with nontoxicity and nonimmunogenicity showed the highest number of preferences. The evaluation of implant options by 31 experts indicated that the engineering characteristic with the highest importance was the condition and sterilization of the surface. These values can be used to set priorities in strategic decisions. Research trials can be aligned to medical preferences, ensuring high product quality and an effective development process. This is the first paper to report on the application of conjoint‐based quality function deployment in biomaterial research.

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“…These materials are able to provide excellent corrosion resistance for metallic substrates such as stainless steel, cobalt-chromium alloys and mild steel [22][23][24][25][26][27][28][29]. In particular, plasma sprayed nanostructure ceramic coatings derived from agglomerated feed stocks had much higher abrasive wear, thermal shock and corrosion resistance than the corresponding conventional coatings.…”

Section: Introductionmentioning

confidence: 98%

Microstructural characterisation of air plasma sprayed nanostructure ceramic coatings on Mg–1%Ca alloys (bonded by NiCoCrAlYTa alloy)

Daroonparvar

Yajid

Yusof

et al. 2016

Ceramics International

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Atmospheric plasma sprayed silica–hydroxyapatite coatings on magnesium alloy substrates

Cited by 56 publications

References 53 publications

Enhance the biocompatibility and osseointegration of polyethylene terephthalate ligament by plasma spraying with hydroxyapatite in vitro and in vivo

Enhance the biocompatibility and osseointegration of polyethylene terephthalate ligament by plasma spraying with hydroxyapatite in vitro and in vivo

Development of magnesium implants by application of conjoint‐based quality function deployment

Microstructural characterisation of air plasma sprayed nanostructure ceramic coatings on Mg–1%Ca alloys (bonded by NiCoCrAlYTa alloy)

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