Atmospheric Pressure Plasmas for Decontamination of Complex Medical Devices

Weltmann, Klaus‐Dieter; Winter, J.; Polák, Martin; Ehlbeck, Jörg; Woedtke, Thomas von

doi:10.1007/978-94-007-2852-3_1

Cited by 9 publications

(6 citation statements)

References 11 publications

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“…In recent decades, plasma discharges have attracted a lot of attention by offering an alternative method for decontaminating surfaces. This is important in, for example, food processing, packaging, or sterilizing medical equipment . Since the development of cold atmospheric pressure plasma (CAP), the decontamination of living biological tissue has been brought into focus as well .…”

Section: Introductionmentioning

confidence: 99%

Inactivation of Microorganisms Using Cold Atmospheric Pressure Plasma with Different Temporal Discharge Characteristics

Mertens¹,

Mahmoodzada²,

Helmke

et al. 2014

Plasma Process. Polym.

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The effect of CAP on the dermatologic relevant bacteria E. coli, P. aeruginosa and the yeast C. albicans is studied in vitro. Two dielectric barrier discharge plasma devices with different temporal pulse characteristics are compared concerning their efficacy of germ inactivation. The study includes analyses of temperature, ozone concentration and UV radiation in the discharge gap as well as the influence on the growth medium in terms of temperature, pH value, NnormalO2−, NnormalO3−, and H2O2. The investigations are concluded by tests of growth inhibition, the morphological structure, and DNA damages of the microorganisms. The results demonstrate, that both devices are able to inactivate the germs, although the nanosecond pulsed plasma source has a higher efficacy based on a higher chemical discharge productivity.

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Section: Introductionmentioning

confidence: 99%

Inactivation of Microorganisms Using Cold Atmospheric Pressure Plasma with Different Temporal Discharge Characteristics

Mertens¹,

Mahmoodzada²,

Helmke

et al. 2014

Plasma Process. Polym.

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“…Plasma medicine emerged in the last decade as an interdisciplinary field of research [50][51][52][53][54][55]. The ultimate goal is the development and proper evaluation procedure for the device generating tissue tolerable plasma (TTP) [56].…”

Section: Methods Of Decontaminationmentioning

confidence: 99%

“…Authors achieved the gas temperature of 49 • C in the plasma gas and in the continuous mode with added oxygen (length of the effluent plasma ranged 11 mm from the nozzle). In the pulsed mode it was 47 • C (length of the effluent plasma was 7 mm from the nozzle) with argon and argon +20% oxygen [51,52,68].…”

Section: Typementioning

confidence: 99%

Atmospheric pressure plasma jet for decontamination purposes

Pawłat

2013

Eur. Phys. J. Appl. Phys.

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Advanced oxidation processes, especially induced by non-thermal plasmas, are widely known for their high sanitation efficiency. The paper presents general overview of atmospheric pressure plasma jet (APPJ) reactors for bactericidal decontamination purposes. In the conclusion part, the basic requirements for APPJ as a tool for biomedical applications including the treatment of living tissues are highlighted.

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“…Cold plasma, also known as non-thermal plasma or atmospheric plasma, is a type of plasma created at or near room temperature, without heating the surrounding gas to high temperatures. Literature shows cold plasma to be a potential alternative to traditional decontamination methods used for food preservation, surface disinfection, medical device sterilization, and surface sterilization in space missions ( Laroussi and Leipold, 2004 ; Ehlbeck et al, 2010 ; Weltmann et al, 2012 ; Mastanaiah et al, 2013 ; Rutala and Weber, 2013 ; Scholtz et al, 2015 ; Choudhury et al, 2018 ; Mandal et al, 2018 ; Gradini et al, 2019 ; Office of Planetary Protection, 2019 ; Bayarri et al, 2021 ; Feizollahi et al, 2021 ; Roy et al, 2021 ; Bhartiya et al, 2022 ; Choudhury et al, 2022 ; Ashokkumar et al, 2023 ; Epelle et al, 2023b ; Choudhury et al, 2023 ; Kaushik et al, 2023 ). Dielectric Barrier Discharge (DBD) is a type of cold plasma which is formed when a high enough alternating voltage is applied across one or more electrodes separated by a dielectric medium.…”

Section: Introductionmentioning

confidence: 99%

Inactivation of SARS CoV-2 on porous and nonporous surfaces by compact portable plasma reactor

Choudhury,

Lednicky,

Loeb

et al. 2024

Front. Bioeng. Biotechnol.

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We report the inactivation of SARS CoV-2 and its surrogate—Human coronavirus OC43 (HCoV-OC43), on representative porous (KN95 mask material) and nonporous materials (aluminum and polycarbonate) using a Compact Portable Plasma Reactor (CPPR). The CPPR is a compact (48 cm3), lightweight, portable and scalable device that forms Dielectric Barrier Discharge which generates ozone using surrounding atmosphere as input gas, eliminating the need of source gas tanks. Iterative CPPR exposure time experiments were performed on inoculated material samples in 3 operating volumes. Minimum CPPR exposure times of 5–15 min resulted in 4–5 log reduction of SARS CoV-2 and its surrogate on representative material samples. Ozone concentration and CPPR energy requirements for virus inactivation are documented. Difference in disinfection requirements in porous and non-porous material samples is discussed along with initial scaling studies using the CPPR in 3 operating volumes. The results of this feasibility study, along with existing literature on ozone and CPPR decontamination, show the potential of the CPPR as a powerful technology to reduce fomite transmission of enveloped respiratory virus-induced infectious diseases such as COVID-19. The CPPR can overcome limitations of high temperatures, long exposure times, bulky equipment, and toxic residuals related to conventional decontamination technologies.

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Atmospheric Pressure Plasmas for Decontamination of Complex Medical Devices

Cited by 9 publications

References 11 publications

Inactivation of Microorganisms Using Cold Atmospheric Pressure Plasma with Different Temporal Discharge Characteristics

Inactivation of Microorganisms Using Cold Atmospheric Pressure Plasma with Different Temporal Discharge Characteristics

Atmospheric pressure plasma jet for decontamination purposes

Inactivation of SARS CoV-2 on porous and nonporous surfaces by compact portable plasma reactor

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