Atmospheric spray-freeze drying: a suitable alternative in freeze-drying technology

Mumenthaler, Marco; Leuenberger, Hans

doi:10.1016/0378-5173(91)90047-r

Cited by 111 publications

(49 citation statements)

References 4 publications

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“…This SFD method is spraying the drug solution over the surface of liquid nitrogen using the nozzle of the spray drier unlike the SFL method. Mumenthaler and Leuenberger 13) use the spray dryer as well as us, however, the freezing temperature makes it freeze at Ϫ70-Ϫ90°C, comparatively high temperature.…”

mentioning

confidence: 99%

Particle Characterization of Poorly Water-Soluble Drugs Using a Spray Freeze Drying Technique

Kondo

Niwa

Okamoto

et al. 2009

CHEMICAL & PHARMACEUTICAL BULLETIN

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657Many newly developing compounds have been dropped out during the early stages of drug development process because of poorly water-soluble property. Poorly water-soluble drugs often demonstrate the low bioavailability when administered orally due to the low dissolution and absorption rate in the gastrointestinal tract. Therefore, improvement of the solubility of poorly water-soluble compounds is an important mission in drug development.Increasing the solubility and dissolution rate of poorly water-soluble drugs is a significant challenge to pharmaceutical scientists. Technologies that have been commonly used to achieve this task include mechanical milling, 1) coprecipitation, 2,3) spray-drying, 4) the complex formation with watersoluble excipients, 5) and freeze-drying. 6) Spray drying has also been widely used as a technique to improve water solubility. However, it is not always appropriate for thermolabile compounds because the spray-drying process requires elevated temperatures. Although lyophilization or freeze-drying is a promising technique to produce pharmaceutical powders with improved solubility, the freezing rate is so slow that this technique is often difficult to apply in the pharmaceutical industry.Spray freezing into liquid nitrogen (SFL) is a novel cryogenic atomization technology, developed by Williams et al. [7][8][9][10][11] in which either an aqueous or an aqueous-organic cosolvent solution containing an active pharmaceutical ingredient (API) and a pharmaceutical excipient is atomized directly into cryogenic liquid nitrogen. This method via atomization resulted in production of fine particles with a significant large specific surface area, with high yields, and has also been found to prevent interparticle aggregation. In addition, when insulin was atomized by this method, it was possible to obtain lower crystallinity while preventing protein aggregation.In our previous work, 12) the solid dispersions were prepared by rapidly cooling of melt drugs in ice or in liquid nitrogen, and it was found that liquid nitrogen was appropriate as a cryogenic source to prepare particle-shaped solid dispersion with amorphous drug. Based on these previous results, we devised new atomization with quick freezing drying (a novel spray freeze drying: SFD) process which combined the spray dryer with the freeze drying equipment. This SFD method is spraying the drug solution over the surface of liquid nitrogen using the nozzle of the spray drier unlike the SFL method. Mumenthaler and Leuenberger 13) use the spray dryer as well as us, however, the freezing temperature makes it freeze at Ϫ70-Ϫ90°C, comparatively high temperature.The objective of this study was to utilize SFD technology for the preparation of composite particles containing a watersoluble polymer and a poorly water-soluble drug. In addition, the particles obtained by SFD were physicochemically characterized in the viewpoint of solubility improvement. ExperimentalMaterials Tolbutamide (TBM), which was commercially purchased from Wako Pure Chemical Indust...

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mentioning

confidence: 99%

Particle Characterization of Poorly Water-Soluble Drugs Using a Spray Freeze Drying Technique

Kondo

Niwa

Okamoto

et al. 2009

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…Besides low temperature, the circulation gas needs to have a very low partial pressure of the solvent vapor so that a mass transfer driving force is available to allow for sublimation of the frozen solvent. ATMFD has been utilized and well studied in the food industry (Meryman 1959 ;Boeh-Ocansey 1983 ) but only recently, in the past 15-20 years, it has begun to gain some traction in the pharmaceutical literature (Mumenthalera and Leuenberger 1991 ;Rogers et al 2003a ) . Its use in the food industry has been entirely focused on the removal of water as a solvent and for this process it has shown great promise.…”

Section: Atmospheric Freeze Drying (Atmfd)mentioning

confidence: 98%

“…In addition to proteins and peptides, SFD was also used for the preparation of amorphous forms of poorly water-soluble drugs, and nonpharmaceutical applications such as food processing (Mumenthalera and Leuenberger 1991 ;Zijlstra et al 2007 ) .…”

Section: Spray Freeze Drying (Sfd)mentioning

confidence: 99%

Pharmaceutical Cryogenic Technologies

Yang¹,

Owens²,

Williams

2011

Formulating Poorly Water Soluble Drugs

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Poor bioavailability associated with poorly water-soluble compounds remains a challenging issue in drug development. Particle engineering may be used to improve the physicochemical properties of poorly water-soluble compounds, thereby enhancing the bioavailability. Cryogenic technologies, including spray freeze drying (SFD), spray freezing into liquid (SFL), and thin fi lm freezing (TFF), are "bottom-up" precipitation processes to generate amorphous nanostructured aggregates with signifi cantly enlarged surface area, higher dissolution rates, and supersaturation, via rapidly inducing nucleation followed by particle growth arrest through stabilization via polymers and solidifi cation of the solvent. This chapter provides detailed description of each cryogenic process, formulation guidelines, and characterization analyses. Finally, examples of cryogenically engineered drug compositions with improved in vitro and in vivo macroscopic performance are provided to illustrate the potential benefi ts of cryogenic technologies, especially TFF.

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“…The liquid blood is frozen to from ice crystals; then the pressure is reduced leading to a sublimation of the ice crystals at a lower temperature and thereby protecting the integrity of the protein. The prerequisite for sublimation is that the vapor pressure and the temperature are held below the triple point of water (0.65 kPa and 0.01°C) (Mumenthaler and Leuenberger 1991). After ice sublimation, a porous structure is formed, which confers to the product a very high hygroscopic ability.…”

Section: Freeze-dryingmentioning

confidence: 99%

Harnessing the Potential of Blood Proteins as Functional Ingredients: A Review of the State of the Art in Blood Processing

Lynch

Mullen

O’Neill

et al. 2017

Comp Rev Food Sci Food Safe

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Blood is generated in very large volumes as a by-product in slaughterhouses all around the world. On the one hand, blood generation presents a serious environmental issue because of its high pollutant capacity; however, on the other hand, blood has the potential to be collected and processed to generate high-added-value food ingredients based on its exceptional nutritive value and its excellent functional properties. In this paper, we review the current state of the art for blood processing, from collection to final recovery of protein isolates, the functional properties of blood, impact of processing on functional properties, and potential applications as food ingredients. Furthermore, future challenges are outlined for this underutilized and abundant product from the meat industry.

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Atmospheric spray-freeze drying: a suitable alternative in freeze-drying technology

Cited by 111 publications

References 4 publications

Particle Characterization of Poorly Water-Soluble Drugs Using a Spray Freeze Drying Technique

Particle Characterization of Poorly Water-Soluble Drugs Using a Spray Freeze Drying Technique

Pharmaceutical Cryogenic Technologies

Harnessing the Potential of Blood Proteins as Functional Ingredients: A Review of the State of the Art in Blood Processing

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