Atomic absorption determination of zinc, copper, cadmium, and lead in tissues solubilized by aqueous tetramethylammonium hydroxide

Murthy, Lalitha; Menden, E.; Eller, Peter M.; Petering, Harold G.

doi:10.1016/0003-2697(73)90082-1

Cited by 71 publications

(17 citation statements)

References 4 publications

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“…Values are quoted from references 8), 12) and [16][17][18][19][20][21][22][23] and expressed as ug/g wet weight or mg/g(#).…”

Section: Discussionmentioning

confidence: 99%

Change in the Concentrations of Metal Elements in Various Organs of the Mouse following Multiple Intraperitoneal Administration of Ca-DTPA.

Sato¹,

Takahashi²,

Suzuki³

et al. 1996

Jpn. J. Health Phys.

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This study was conducted to investigate the effect of diethylenetriaminepentaacetic acid (DTPA) on the concentrations of some metal elements in mouse organs to accumulate fundamental knowledge on its pharmacological properties and its side effects. DTPA was injected intraperitoneally into C3H/He mice 3 times per week at a dose of 0.3mmol per kg body weight, and the concentrations of 13 metal elements in the liver, spleen kidneys, lungs, femur and serum were measured by inductively coupled plasma emission spectrometry and atomic absorption spectrometry up to 8 weeks after the start of administration.The concentrations of Co, Cr, Ni, Ti and V were at undetectable levels in the control and treated groups throughout the experimental period in all the organs examined. The concentrations of Ca slightly changed with the DTPA treatment in the liver and femur. The concentrations of Mn in the liver and P in the femur also slightly changed with the DTPA treatment, but no general tendency was apparent. The concentrations of Cu and Al significantly increased with the DTPA treatment in the liver and kidneys and Zn also increased in the kidneys. The concentrations of Mg significantly decreased with the DTPA treatment in all the organs except the lungs. The Fe concentrations tended to decrease in the liver and spleen, although the decrease was slight. In conclusion, the concentrations of several metal elements were changed by the administration of Ca-DTPA, but the change was small.

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“…Values are quoted from references 8), 12) and [16][17][18][19][20][21][22][23] and expressed as ug/g wet weight or mg/g(#).…”

Section: Discussionmentioning

confidence: 99%

Change in the Concentrations of Metal Elements in Various Organs of the Mouse following Multiple Intraperitoneal Administration of Ca-DTPA.

Sato¹,

Takahashi²,

Suzuki³

et al. 1996

Jpn. J. Health Phys.

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“…The dried samples were wet-ashed with 4:1 nitric:perchloric acids. They were taken to near dryness and dissolved in 10% nitric acid for analysis ofZn and Cu by atomic absorption spectrometry [17], All values were expressed as pg/g of dry weight (ppm) unless otherwise stated.…”

Section: Methodsmentioning

confidence: 99%

Copper Deficiency Effects on Cardiovascular System and Lipid Metabolism in the Rat; the Role of Dietary Proteins and Excessive Zinc

et al. 1985

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Weanling rats were fed a copper-deficient purified diet. The effects of varying the type of protein and supplements of copper and zinc on cardiovascular pathology and some biochemical parameters were investigated. It was found that cardiomyopathy developed in the copper-deficient groups. Milk powder caused significant exacerbation of this development relative to dietary casein or egg white. Angiopathy developed only when dietary zinc was 20 ppm. Dietary copper did not change this situation. Serum cholesterol was elevated when copper was low and casein or milk powder were the protein source. The data point to an interaction between type of protein and dietary copper or zinc in the pathogenesis of cardiovascular lesions.

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“…Reference laboratory methods for measuring lead include graphite‐furnace atomic absorption spectrophotometry and inductively coupled plasma mass spectrometry (ICP‐MS; Murthy et al , Ting and Janghorbani ). However, these methods require expensive equipment and time, and are not practical for quick assessment in the field or at a treatment facility.…”

Section: Lead Ingestion By Raptorsmentioning

confidence: 99%

Guidelines for evaluation and treatment of lead poisoning of wild raptors

et al. 2017

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Lead poisoning is a threat to birds, particularly scavenging birds of prey. With the availability of portable lead-testing kits, an increasing number of field researchers are testing wild-caught birds, in situ, for lead poisoning. We describe guidelines for evaluation of lead toxicity in wild raptors by outlining field testing of blood-lead concentrations, presenting criteria for removing a lead-poisoned bird from the wild for treatment, and suggesting strategies for effective treatment of lead intoxicated raptors. Field testing of birds is most commonly accomplished via portable electrochemical analysis of blood; visual observation of condition alone may provide insufficient evidence upon which to make a decision about lead poisoning. Our intended audience is not only the avian research community, but also rehabilitation facilities that may receive apparently uninjured birds. Best practices suggest that birds whose blood-lead levels are <40 mg/dL be released back to the wild as soon as possible after capture. The decision to release or treat birds with bloodlead levels between 40 mg/dL and 60 mg/dL should be made based on the presence of clinical signs of poisoning and relevant biological characteristics (e.g., breeding status). Finally, birds with blood-lead levels >60 mg/dL are potentially lethally poisoned and best served if removed from the wild for appropriate treatment at a licensed rehabilitation facility and later released. We present guidelines for decision-making when treating lead poisoning of wild raptors. Future work based on experimental studies will clarify the role of lead poisoning for specific species and be important to refine these guidelines to improve effectiveness.

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Atomic absorption determination of zinc, copper, cadmium, and lead in tissues solubilized by aqueous tetramethylammonium hydroxide

Cited by 71 publications

References 4 publications

Change in the Concentrations of Metal Elements in Various Organs of the Mouse following Multiple Intraperitoneal Administration of Ca-DTPA.

Change in the Concentrations of Metal Elements in Various Organs of the Mouse following Multiple Intraperitoneal Administration of Ca-DTPA.

Copper Deficiency Effects on Cardiovascular System and Lipid Metabolism in the Rat; the Role of Dietary Proteins and Excessive Zinc

Guidelines for evaluation and treatment of lead poisoning of wild raptors

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