Atomic absorption spectrometric determination of sub-part-per-million quantities of tin in extracts and biological materials with a graphite furnace

Trachman, Helen; Tyberg, Albert J.; Branigan, Patrick D.

doi:10.1021/ac50016a009

Cited by 31 publications

(4 citation statements)

References 7 publications

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“…Analysis of tin followed the method of Trachman et al (1977). 'Tissue samples were solubilized in Protosol (New England Nuclear), and tin was determined using a Perkin Elmer 306 atomic absorption spectrometer equipped with a HGA 2100 graphite rod furnace (Perkin Elmer, Norwalk, Connecticut).…”

Section: Other Analytical Methodsmentioning

confidence: 99%

Effect of Triethyl Tin on Myelination in the Developing Rat

Blaker¹,

Krigman²,

Thomas³

et al. 1981

Journal of Neurochemistry

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Myelinogenesis in developing rats was studied following chronic dosing with triethyl tin (TET), at a level of 1.0 mg TET/kg body wt/day. Experiments included starved controls with body weights depressed by 17 to 40% to equal those of the TET-treated groups. Rats at ages of 16, 21, and 30 days showed decreases relative to well-nourished controls in body weight, forebrain weight, myelin yield, cerebroside level, and specific activity of brain 2',3'-cyclic nucleotide-3'-phosphohydrolase when dosed with TET. At 30 days, myelin and cerebroside yields were reduced by approximately 55%, while CNP activity was reduced by less than 20%. No differences in the forebrain myelin protein composition between control, starved, and TET animals were noted. The rate of myelin protein synthesis relative to brain total protein (assayed by incorporation of intracranially injected [3H]glycine into brain homogenate and myelin proteins) was decreased in the TET rats in proportion to the decreased yield of myelin, but no particular myelin protein was preferentially affected. Matching starved controls exhibited similar body weight decreases, less pronounced forebrain weight decreases, and little or no decrease in myelin concentration. There was a relative increase in the myelin protein synthesis rate in the starved rats, indicating preferential utilization of limited protein precursors for myelin protein synthesis. Spinal cord myelin was also decreased in the TET rats, but less severely than in the forebrain. At all ages optic, but not sciatic, nerves showed decreases in myelin concentration with TET treatment. We conclude that TET inhibits forebrain growth and CNS myelination more severely than can be accounted for by a general metabolic insult.

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Section: Other Analytical Methodsmentioning

confidence: 99%

Effect of Triethyl Tin on Myelination in the Developing Rat

Blaker¹,

Krigman²,

Thomas³

et al. 1981

Journal of Neurochemistry

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“…The method is in use in several laboratories for other metals (Brinckman et al 1976, Parris et al 1977, Trachman et al 1977 and contact was maintained with workers at the National Bureau of Standards throughout the project.…”

Section: Resultsmentioning

confidence: 99%

An evaluation of Chester River oyster mortality /

Cooney¹,

Martin²,

Roosenberg³

et al. 1979

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Program to conduct a study concerning oyster mortality in the Chester River, a subestuary of the Chesapeake Bay. The State of Maryland contracted with the University of Maryland to perform a three-part study to evaluate the reported oyster mortality. Due to the fact that this was a retrospective study, the evaluation of past large instananeous inputs of chemicals and the resulting potential impact was not made. The results of the University of Maryland's research follows.

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“…Tin quantity was determined by atomic absorption (Trachman et al, 1977) using a spectrophotometer (Perkin-Elmer, Model 403) equipped with a graphite furnace (Model HGA-74). Lead was also determined by use of the graphite furnace (Christian and Feldman, 1970).…”

Section: Camosciand Tinanoffmentioning

confidence: 99%

Anti-bacterial Determinants of Stannous Fluoride

Camosci

Tinanoff

1984

J Dent Res

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The growth of bacteria on stainless steel wires was used as a model to investigate which properties of SnF2 produced anti-bacterial effects against S. mutans. Wire-adherent bacteria were exposed for one min, twice a day, to various fluoride or control compounds having similar ions, pH, valence, or atomic weights. After two days, the thickness of adherent bacteria was scored visually, and the decrease in pH of the growth medium was determined. Bacteria from each wire were then dried, weighed, and analyzed for metal content. Electron microscopy and electron microprobe were used to identify the location of heavy metal deposits in the bacteria. Only SnF2 dramatically altered S. mutans growth and metabolism, and this anti-bacterial effect was associated with a large uptake of tin into the bacterial cells. The fluoride salts of sodium, lead, zinc, and copper had little influence on S. mutans growth in this test system. The pH of the various fluoride salts or controls generally had no effect on the activity of the test compounds, except for the noted inactivation of SnF2 at elevated pH's. Since SnF4 did not alter the growth or metabolism of S. mutans, a unique property of SnF2--possibly the reactivity in an aqueous environment--may be responsible for its anti-bacterial properties.

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Atomic absorption spectrometric determination of sub-part-per-million quantities of tin in extracts and biological materials with a graphite furnace

Cited by 31 publications

References 7 publications

Effect of Triethyl Tin on Myelination in the Developing Rat

Effect of Triethyl Tin on Myelination in the Developing Rat

An evaluation of Chester River oyster mortality /

Anti-bacterial Determinants of Stannous Fluoride

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