Atomic layer deposition of zinc oxide onto 3D porous iron scaffolds for bone repair: in vitro degradation, antibacterial activity and cytocompatibility evaluation

Li, Yu-Lei; He, Jinguang; Ye, Hai-Xia; Zhao, Chong; Zhu, Weiwei; Li, Xiong; Ren, Fuzeng

doi:10.1007/s12598-021-01852-8

Cited by 12 publications

(9 citation statements)

References 66 publications

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“…For example, Li et al. [ 222 ] deposited a nano-ZnO film on the surface of 3D porous iron scaffolds using the atomic layer deposition technique, and then they found that the ZnO@Fe scaffolds display extremely strong antibacterial ability against both Gram-positive and Gram-negative bacteria and provide a better environment for cell adhesion, without affecting the cytocompatibility of porous scaffolds. In addition, the ZnO film greatly reduces the degradation rate of the scaffolds.…”

Section: Antibacterial Coatingsmentioning

confidence: 99%

Antibacterial coatings on orthopedic implants

Chen¹,

Qian²,

Zhao³

2023

Materials Today Bio

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Section: Antibacterial Coatingsmentioning

confidence: 99%

Antibacterial coatings on orthopedic implants

Chen¹,

Qian²,

Zhao³

2023

Materials Today Bio

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“…Reprinted with permission. 24,25 Different technologies can also be used to compound and improve the defects in certain types of manufacturing technology. Compared with SLM and SLS technologies, 3D gel printing technology is more efficient and less expensive, but does not impart high porosity.…”

Section: Magnesium-based Alloysmentioning

confidence: 99%

Research progress in degradable metal‐based multifunctional scaffolds for bone tissue engineering

He,

Li,

et al. 2023

MedComm – Biomaterials and Applications

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The increasing prevalence of orthopedic‐related diseases necessitates the development of effective orthopedic implants. Conventional metal scaffolds used in orthopedic devices have limitations such as poor biocompatibility and the need for a second surgery to remove the scaffold. Degradable metal‐based scaffolds, including metal‐based scaffolds and multifunctional scaffolds doped with metal elements, are a rapidly developing tissue engineering strategy aimed at utilizing the mechanical and biological properties of metal elements to create a support structure that matches the complex bone regeneration environment. Repairing bone defects involves the regeneration of various tissues, and incomplete repair can negatively affect bone function and overall recovery. Therefore, combining metal‐based degradable materials with other active components has great potential for enhancing the versatility and clinical applications of scaffolds. Multifunctional scaffolds doped with metal elements have better biocompatibility, osteoinductivity, biodegradability, matching mechanical, and microenvironmental adjustment capabilities. Moreover, these metal‐doped scaffolds possess the advantages of controlled release of metal ions, multifunctionality, and faster degradation. This review focuses on the materials and techniques used for constructing degradable metal‐based scaffolds. Furthermore, this study discussed the potential for designing and constructing multifunctional biodegradable metal‐based scaffolds doped with metal elements by integrating multiple strategies.

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“…Thin film deposition is an economic and scalable surface modification technique for the precise tuning of the chemical and physical properties, such as topography, hardness, corrosion property of a substrate. Several techniques, such as sputtering [84], thermal evaporation [85], chemical vapour deposition [86], atomic layer deposition [87], electrochemical deposition [88,89], electron beam deposition [16] etc., Can be employed for the fabrication of topographical surfaces. Lee et al [90] deposited ZrO 2 -ZnO-TiO 2 ultrathin nanocomposite coatings on the stainless steel by the radio frequency sputtering method.…”

Section: Thin Film Depositionmentioning

confidence: 99%

Topographical biointerface regulating cellular functions for bone tissue engineering

Zhu

Zhang

Mao

et al. 2022

Biosurface and Biotribology

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The physiochemical properties of the implant interface significantly influence cell growth, differentiation, cellular matrix deposition, and mineralisation, and eventually, determine the bone regeneration efficiency. Cells directly sense and respond to the physical, chemical, and mechanical cues of the implant surface, and it is increasingly recognized that surface topography can evoke specific cellular responses, conferring biological functions on substrate materials and regulating tissue regeneration. Current progress towards the fundamental understanding of the interplay between the cell and topographical surface has been made by combined advance in fabrication technologies and cell biology. Particularly, the precise fabrication and control of nano/microscale topographies can provide the fundamental knowledge of the mechanotransduction process that governs the cellular response as well as the knowledge of how the specific features drive cells towards a defined differentiation outcome. In this review, we first introduce common techniques and substrate materials for designing and fabricating micro/nano‐topographical surfaces for bone regeneration. We then illustrate the intrinsic relationship of topological cues, cellular signal transduction, and cell functions and fates in osteogenic differentiation. Finally, we discuss the challenges and the future of using topological cues as a cell therapy to direct bone tissue regeneration.

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Atomic layer deposition of zinc oxide onto 3D porous iron scaffolds for bone repair: in vitro degradation, antibacterial activity and cytocompatibility evaluation

Cited by 12 publications

References 66 publications

Antibacterial coatings on orthopedic implants

Antibacterial coatings on orthopedic implants

Research progress in degradable metal‐based multifunctional scaffolds for bone tissue engineering

Topographical biointerface regulating cellular functions for bone tissue engineering

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