2017
DOI: 10.1038/srep40289
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Atomization of High-Viscosity Fluids for Aromatherapy Using Micro-heaters for Heterogeneous Bubble Nucleation

Abstract: The development of a novel lead-free microelectromechanical-system (MEMS)-based atomizer using the principle of thermal bubble actuation is presented. It is a low-cost, lead-free design that is environmentally friendly and harmless to humans. It has been tested to be applicable over a wide range of fluid viscosities, ranging from 1 cP (e.g., water) to 200 cP (e.g., oil-like fluid) at room temperature, a range that is difficult to achieve using ordinary atomizers. The results demonstrate that the average power … Show more

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Cited by 7 publications
(7 citation statements)
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“… 47 , 48 , 49 In addition, gene therapy medications are DNA and mRNA molecules wrapped with polymers, peptide chains, and lipids in the outer layer; therefore, the viscosity of the medication is higher than 10 cP. Currently, the viscosity for the atomization of high-viscosity liquids is usually reduced by heating, 50 but the high temperature tends to denature the medication and is therefore unsuitable for biomedical applications. 51 our team has proposed a two-dimensional vibration-coupled structure to supply high energy input to the liquid.…”
Section: Introductionmentioning
confidence: 99%
“… 47 , 48 , 49 In addition, gene therapy medications are DNA and mRNA molecules wrapped with polymers, peptide chains, and lipids in the outer layer; therefore, the viscosity of the medication is higher than 10 cP. Currently, the viscosity for the atomization of high-viscosity liquids is usually reduced by heating, 50 but the high temperature tends to denature the medication and is therefore unsuitable for biomedical applications. 51 our team has proposed a two-dimensional vibration-coupled structure to supply high energy input to the liquid.…”
Section: Introductionmentioning
confidence: 99%
“…In 2010, A. Lozano et al used a piezoelectric ceramic disc structure to achieve ultrasonic atomization of liquids with a kinematic viscosity of 28 cSt [34] . In 2017, Junhui Law et al implanted a microheater into an atomization device to achieve atomization of liquids with viscosities of 1 cP − 200 cP, using heating to generate large amounts of gas nuclei [35] . However, heat could destroy or degrade medicines, and the design is too complex to be used in the pharmaceutical field.…”
Section: Introductionmentioning
confidence: 99%
“…These types of atomizers have their own advantages and disadvantages, but compared with static mesh atomizers, dynamic mesh atomizers do not need a liquid cavity with variable volume, greatly simplifying the structure and effectively solving the problems of the low energy utilization rate and large droplet size. In addition, given its advantages, such as low cost, low energy consumption, and uniform atomizing particle size, dynamic mesh atomizers have been widely used in air humidification, spray cooling, biomedicine, aromatherapy, atomizing inhalation therapy, and other fields [3][4][5][6][7][8][9][10].…”
Section: Introductionmentioning
confidence: 99%