Atomoxetine Induced Obsessive-Compulsive Disorder

Altay, Mengühan Araz

doi:10.15171/hpr.2019.12

Cited by 2 publications

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Atomoxetine Induced Skin Picking: A Case Report

Kasar

Yurteri

2020

Clin Neuropharm

View full text Add to dashboard Cite

“Skin picking disorder,” also known as “dermatillomania” or “psychogenic excoriation,” is classified in the “Obsessive Compulsive and Related Disorders” category in Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition and characterized by repetitive skin picking behaviors resulting in skin lesions. Atomoxetine (ATX) is a selective norepinephrine (noradrenaline) reuptake inhibitor commonly used in the management of attention-deficit/hyperactivity disorder. Atomoxetine is considered to increase levels of noradrenaline and dopamine by inhibiting norepinephrine transporters. In this case report, we present an 8-year-old male attention-deficit/hyperactivity disorder patient with skin picking behavior due to ATX treatment. We discussed possible explanations of skin picking behavior with ATX in the light of the current literature. To our knowledge, this is the first report of skin picking due to ATX in literature, and further studies are needed to investigate the frequency and mechanisms of skin picking with ATX.

show abstract

Atomoxetine Induced Skin Picking: A Case Report

Kasar

Yurteri

2020

Clin Neuropharm

View full text Add to dashboard Cite

show abstract

Noradrenergic and Pavlovian underpinnings of compulsive versus adaptive coping strategies

Chernoff,

Belin-Rauscent,

Puaud

et al. 2024

Preprint

View full text Add to dashboard Cite

Loss of control over coping strategies can result in the development of impulsive/compulsive spectrum disorders (ICSDs) such as Obsessive-Compulsive Disorder or trichotillomania. Rats, like humans, show individual differences in their tendency to engage in and maintain control over coping behaviours. While most rats exposed to a schedule-induced polydipsia (SIP) procedure develop a controlled coping response, namely polydipsic drinking, some engage in excessive, compulsive drinking, or hyperdipsia. The development of hyperdipsia, to which highly impulsive rats are particularly vulnerable, depends on noradrenergic mechanisms as it is prevented by the noradrenaline reuptake inhibitor, atomoxetine. However, whether noradrenergic mechanisms also underlie the maintenance of well-established compulsive coping or if other traits confer vulnerability to its development, are unknown. In two longitudinal studies in male Sprague Dawley rats, we investigated whether well-established hyperdipsia is influenced by atomoxetine and if its development is predicted by the ICSD-relevant sign-tracking trait. Sign-tracking predicted faster acquisition of adjunctive drinking but not the transition to hyperdipsia, which goal-tracking protected against. Surprisingly, chronic atomoxetine exacerbated well-established hyperdipsia. Post-mortem qPCR assays revealed that the exacerbation of compulsive coping by atomoxetine was associated with increased mRNA levels of the markers of cellular activity and plasticity c-fos and Zif268 across the dorsal striatum. Atomoxetine also altered the hyperdipsia-specific transcriptomic landscape of the nucleus accumbens shell and the pattern of c-fos and Zif268 expression in the amygdala-accumbens system. These results provide new insights into the biobehavioural basis of compulsive behaviours, revealing a differential noradrenergic control of the development and the expression of compulsive coping

show abstract

Atomoxetine Induced Obsessive-Compulsive Disorder

Cited by 2 publications

References 15 publications

Atomoxetine Induced Skin Picking: A Case Report

Atomoxetine Induced Skin Picking: A Case Report

Noradrenergic and Pavlovian underpinnings of compulsive versus adaptive coping strategies

Contact Info

Product

Resources

About