Atopic dermatitis and gestational age – is there
an association between them? A review of the literature
and an analysis of pathology

Kowalik, Aleksandra; Cichocka‐Jarosz, Ewa; Kwinta, Przemko

doi:10.5114/ada.2023.128999

Cited by 4 publications

(3 citation statements)

References 56 publications

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“…In our study, prematurity was positively related to the future development of asthma and AR in the pediatric population, while being protective against the development of AD. These results are consistent with ndings from other nationwide databases or reviews on asthma and AD, with a stronger correlation observed as gestational age decreases 6, [15][16][17] . Although beyond the scope of this study, the possible etiology of prematurity-associated asthma is multifactorial.…”

Section: Discussionsupporting

confidence: 91%

“…Factors may include the underdevelopment of the airway, antibiotic use, increased risks for viral respiratory infections, decreased breastfeeding, and altered microbiota 18 . On the other hand, the cause for the association of prematurity with a lower risk of AD was proposed to be the increased permeability of their immature skin, early antigen exposure in the neonatal intensive care unit (NICU), and altered skin microbiota 17 .…”

Section: Discussionmentioning

confidence: 99%

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Atopic diseases in pediatric population: prematurity and small for gestational age

Su,

Chen,

Chen

et al. 2024

Preprint

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The aim of our study was to conduct a national-wide longitudinal follow-up investigation to elucidate the association between prematurity, small for gestational age (SGA), and later development of atopic diseases in pediatric population. Research data was obtained from Taiwan’s National Health Insurance Research Database (NHIRD). Our cohort included infants born between 1 January 2004 and 31 December 2019 with exclusion of death during follow-up period and multiple births. Children born prematurely or SGA were identified as study cases and those born term and appropriate for gestational age (AGA) as controls. Data was then analyzed and adjusted for covariates. A total of 1,758,460 infants comprising 914,713 male and 843,747 female were included in the study. Prematurity was associated with atopic rhinitis (AR) (HR, 1.03, male and HR, 1.03, female), asthma (HR, 1.19, male and HR, 1.17, female) and protective against atopic dermatitis (AD) (HR, 0.94, male and HR, 0.95, female) in both male and female AGA groups. SGA were not associated with atopic diseases in term infants. Further investigations are required to clarify the underlying mechanisms and establish the causal relationship of the issue.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Atopic diseases in pediatric population: prematurity and small for gestational age

Su,

Chen,

Chen

et al. 2024

Preprint

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“…It was determined that the lung functions of pretermborn children decreased significantly at school age [7][8][9][10]. In addition, various studies investigating atopy in premature children have been conducted, some studies have shown that atopy is a reduced risk factor, while others have shown that there is no relationship between gestational age and atopy [10][11][12][13][14][15][16]. In this study, it was aimed to determine the respiratory functions and atopy susceptibility of preterm and term patients hospitalized for respiratory distress in the neonatal period and healthy children and to compare the results.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2024

Eu Clin Anal Med

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Aim: In this study, we aimed to determine the predisposition for atopy and pulmonary functions of patients who were followed up for respiratory distress syndrome in the neonatal period. Material and Methods: Fifty children hospitalized with respiratory distress in the neonatal period were included in the study, and the control group included 31 children, who had no respiratory problems, were included as the control group. Pulmonary function test was performed to evaluate the lung functions of the children included in the study. A Chest x-ray was performed. Total IgE and phadiaotope were studied in serum samples. A Skin prick test was done. Results: Serum total IgE results in the patient group were statistically significantly higher than in the control group (p=0.02). Of the 50 patients in the patient group, 5 (10%) had atopic asthma, 4 (8%) had nonatopic asthma, 2 (4%) had bronchopulmonary dysplasia, 2 (4%) had atopic dermatitis and 2 (4%) had allergic rhinitis. When 50 patients were examined in terms of atopy, 10 (20%) were considered atopic. In the control group, 1 child (3.2%) was considered atopic. Atopy was found to be statistically significantly higher in the patient group (p=0.03). Although the FVC, FEV1, FEV1/FVC and PEF values measured in the patient group were lower than those in the control group, the results were not statistically significant. Discussion: Diagnoses of atopic disease (atopic asthma, allergic rhinitis, atopic dermatitis), non-atopic asthma and bronchopulmonary dysplasia were found to be higher in patients followed up for respiratory distress in the neonatal period compared to the control group without respiratory problems.

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Neonatal and early infancy antibiotic exposure is associated with childhood atopic dermatitis, wheeze and asthma

Räty,

Ollila,

Turta

et al. 2024

Eur J Pediatr

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Antibiotics are frequently administered in the neonatal period and early infancy. Little is known about the long-term health consequences of early life antibiotic exposure. The objective is to investigate the association between neonatal and early life (0–6 months) antibiotic treatment and the development of atopic dermatitis, asthma and the use of inhaled corticosteroid medication later in childhood. We analyzed data obtained from hospital records and national registers in a cohort of 11,255 children. The association between early antibiotic exposure and the outcomes were analyzed using logistic regression. Confounding factors were included in the model. Neonatal antibiotic therapy for confirmed infection was associated with childhood atopic dermatitis (adjusted odds ratio 1.49; 95% confidence interval 1.15–1.94). Antibiotic therapy by six months of age was more common in children developing atopic dermatitis (adjusted odds ratio 1.38; 95% confidence interval 1.15–1.64), asthma (adjusted odds ratio 1.56; 95% confidence interval 1.32- 1.85) and inhaled corticosteroid medication use (adjusted odds ratio 1.88; 95% confidence interval 1.66–2.13). Conclusions: Neonatal antibiotic therapy for confirmed or clinically diagnosed infection is associated with increased risk of atopic dermatitis later in childhood. Antibiotic treatment before six months of age is associated with atopic dermatitis, asthma and inhaled corticosteroid use. What is known:• The use of antibiotics early in life has been associated with an increased risk of developing atopic dermatitis or asthma.• Confounding by indication or reverse causation may underlie the observed associations. What is new:• Our results demonstrate that neonatal antibiotic therapy for confirmed or clinically diagnosed infection was associated with increased risk of atopic dermatitis and antibiotic treatment before six months of age was associated with atopic dermatitis, asthma and inhaled corticosteroid use in analyses adjusted for confounding factors.

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Atopic dermatitis and gestational age – is there an association between them? A review of the literature and an analysis of pathology

Cited by 4 publications

References 56 publications

Atopic diseases in pediatric population: prematurity and small for gestational age

Atopic diseases in pediatric population: prematurity and small for gestational age

Untitled

Neonatal and early infancy antibiotic exposure is associated with childhood atopic dermatitis, wheeze and asthma

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