Atopic Dermatitis in Children: Preand Perinatal Risk Factors

Abstract

Background. To study the influence of some pre- and perinatal factors on risk of atopic dermatitis development in children up to 3 years old. Materials and methods. 460 newborns and children histories up to 3 years old as well as pregnancy and delivery medical reports of their mothers have been analyzed. The data were estimated differentially depending on presence or absence of atopic dermatitis in 3 years old children. Results. The most significant perinatal risk factors for development of atopic dermatitis were: family history of atopy in mother (OR 3,99 [95% CI 2,38; 6,72]), gestosis, fetoplacentary insufficiency (OR 1,65 [95% CI 1,08; 2,54]), threat of interruption of pregnancy failure (OR 1,82 [95% CI 1,21; 2,74]), fed by a milk formulas (OR 1,70 [95% CI 1,13; 2,56]), cytomegalovirus (OR 1,56 [95% CI 1,02; 2,41])and ureaplasma infection in anamnesis (OR 1,77 [95% CI 1,10; 2,78]), and antibiotics (macrolids) intake during pregnancy. Conclusions. The influence of some pre- and perinatal risk factors of atopic dermatitis in children of early age has been demonstrated.