Atopic Dermatitis in Israeli Adolescents from 1998 to 2013: Trends in Time and Association with Migraine

Shreberk‐Hassidim, Rony; Hassidim, Ayal; Gronovich, Yoav; Dalal, Adam; Molho‐Pessach, Vered; Zlotogorski, Abraham

doi:10.1111/pde.13084

Cited by 21 publications

(12 citation statements)

References 21 publications

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“…It is possible that individuals with severe AD have a higher prevalence of adverse cardiovascular events because of shared associated factors such as obesity, smoking, hypertension, and diabetes. Migraine has previously been linked to allergic diseases such as asthma and allergic rhinitis, and some studies have reported an association with AD in children and adolescents as well [7,8]. Our study adds new knowledge about the increased prevalence of migraine and headache in adults with AD.…”

Section: Discussionmentioning

confidence: 55%

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Associations of self-reported atopic dermatitis with comorbid conditions in adults: a population-based cross-sectional study

et al. 2020

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Background The objective of this study was to investigate the relationships between atopic dermatitis (AD) and other common chronic health conditions in adults. Methods A cross-sectional survey was sent to a randomly selected population sample of 78,004 adults in Sweden. The questionnaires included measures of self-reported physical and mental health. Binary and multinomial logistic regression were used to examine the associations of AD with common chronic health conditions and psychological wellbeing. Results AD was self-reported by 4,175 respondents, representing almost 14% of the study population of 34,313 adults. Our results showed positive associations between AD and chronic health disorders, including conditions of the oral cavity: chronic obstructive pulmonary disease (adjusted odds ratio [aOR] = 1.58, 95% confidence interval [CI]: 1.30 to 1.92), asthma (aOR = 2.13, 95% CI: 1.91 to 2.38), mild recurrent gastrointestinal symptoms (adjusted relative risk ratio [aRRR] = 1.78, 95% CI: 1.64 to 1.92), high blood pressure (aOR = 1.16, 95% CI: 1.06 to 1.26), obesity (aOR = 1.34, 95% CI: 1.23 to 1.47), mild joint pain (aRRR = 1.47, 95% CI: 1.35 to 1.61), mild headache or migraine (aRRR = 1.50, 95% CI: 1.38 to 1.64), caries (aOR = 1.25, 95% CI: 1.04 to 1.49), bleeding gums (aOR = 1.69, 95% CI: 1.38 to 2.08), periodontitis (aOR = 1.42, 95% CI: 1.13 to 1.77), sensitive teeth (aOR = 1.57, 95% CI: 1.35 to 1.82), and dry mouth (aOR = 1.52, 95% CI: 1.33 to 1.74). Adjustment for asthma and depression attenuated the magnitude of the associations between AD and the study outcomes. AD was also associated with poorer general psychological wellbeing. Conclusions Adults reporting AD may be at increased risk of chronic disorders and decreased psychological wellbeing. Physicians should recognize that individuals with severe AD and those with comorbid asthma or depression may be especially vulnerable.

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Section: Discussionmentioning

confidence: 55%

“…Further, smoking has been reported to be associated with both AD and COPD, suggesting that it may be a shared risk factor for the two diseases. Co-occurrence of migraine has also been observed in individuals with AD [7,8].…”

Section: Introductionmentioning

confidence: 93%

Associations of self-reported atopic dermatitis with comorbid conditions in adults: a population-based cross-sectional study

et al. 2020

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“…Patients with moderate to severe AD were defined as patients who had received systemic corticosteroids. 13–16 The exclusion criterion was any diagnosis of a keloid (ICD-9-CM code 701.4) before the index date. 17 During the follow-up period, the occurrence of keloid was defined as ≥3 keloid diagnoses in outpatient visits or ≥1 keloid diagnoses in inpatient medical service.…”

Section: Methodsmentioning

confidence: 99%

Keloid risk in patients with atopic dermatitis: a nationwide retrospective cohort study in Taiwan

et al. 2018

BMJ Open

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ObjectiveThe pathogenesis of keloid is largely unknown. Because keloid and atopic dermatitis have overlapping pathophysiological mechanisms, we aimed to evaluate keloid risk in patients with atopic dermatitis.Study designPopulation-based retrospective cohort study.SettingThe Taiwan National Health Insurance Research Database was used to analyse data for people who had been diagnosed with atopic dermatitis.ParticipantsWe identified 8371 patients with newly diagnosed atopic dermatitis during 1996–2010. An additional 33 484 controls without atopic dermatitis were randomly identified and frequency matched at a one-to-four ratio.Primary and secondary outcome measureThe association between atopic dermatitis and keloid risk was estimated using Cox proportional hazard regression models.ResultsAfter adjustment for covariates, the atopic dermatitis patients have a 3.19-fold greater risk of developing keloid compared with the non-atopic dermatitis group (3.19vs1.07 per 1000 person-years, respectively). During the study period, 163 patients with atopic dermatitis and 532 patients without atopic dermatitis developed keloid. Notably, keloid risk increased with severity of atopic dermatitis, particularly in patients with moderate to severe atopic dermatitis.ConclusionsOur results indicate that patients with atopic dermatitis had a higher than normal risk of developing keloid and suggest that atopic dermatitis may be an independent risk factor for keloid.

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“…15,16 In Canada, the prevalence of AD in children from Indigenous communities is higher than the prevalence reported in major cities, ranging from 16.5% to 27.6% in Iqaluit and a Native Reserve in Labrador. [17][18][19] In addition to racial differences, sociodemographic and economic determinants of health may play a role in AD prevalence, [20][21][22] with most studies reporting a correlation between higher socioeconomic status and increased AD prevalence. 23…”

Section: Epidemiologymentioning

confidence: 99%

Approach to the Assessment and Management of Pediatric Patients With Atopic Dermatitis: A Consensus Document. Section I: Overview of Pediatric Atopic Dermatitis

et al. 2019

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Pediatric atopic dermatitis (AD) is one of the most common dermatoses encountered by health-care providers treating children. Diagnosis of AD is clinical, with no universally accepted biomarkers or assessment tools. Patient-reported outcomes and subjective assessments of quality of life in both the patient and family are important considerations when treating pediatric AD. Here, we provide an overview of pediatric AD epidemiology, its clinical presentation, burden, diagnosis, and assessment, with a focus on implications for patient counseling in order to optimize care.

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Atopic Dermatitis in Israeli Adolescents from 1998 to 2013: Trends in Time and Association with Migraine

Cited by 21 publications

References 21 publications

Associations of self-reported atopic dermatitis with comorbid conditions in adults: a population-based cross-sectional study

Associations of self-reported atopic dermatitis with comorbid conditions in adults: a population-based cross-sectional study

Keloid risk in patients with atopic dermatitis: a nationwide retrospective cohort study in Taiwan

Approach to the Assessment and Management of Pediatric Patients With Atopic Dermatitis: A Consensus Document. Section I: Overview of Pediatric Atopic Dermatitis

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