Atopic dermatitis-like skin lesions with IgE hyperproduction and pruritus in KFRS4/Kyo rats

Kuramoto, Takashi; Yokoe, Mayuko; Tanaka, Daisuke; Yuri, Azusa; Nishitani, Ai; Higuchi, Yuki; Yoshimi, Kazuto; Tanaka, Miyuu; Kuwamura, Mitsuru; Hayashi, Hiroshi; Kabashima, Kenji; Serikawa, Tadao

doi:10.1016/j.jdermsci.2015.09.005

Cited by 13 publications

(9 citation statements)

References 30 publications

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“…Chronic urticaria (CU) is a common dermatologic condition characterized by pruritus, redness swelling, and wheals with important repercussion on the quality of life [78][79][80]. Limited data are available on a sex-gender perspective of CU.…”

Section: Urticariamentioning

confidence: 99%

Sex and Gender Aspects for Patient Stratification in Allergy Prevention and Treatment

Martinis

Sirufo

Suppa

et al. 2020

IJMS

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Allergies are rapidly worsening in recent decades, representing the most common immunological diseases. The mechanism of disorders such as asthma, rhinocongiuntivitis, urticaria, atopic dermatitis, food and drug allergies, and anaphylaxis still remain unclear and consequently treatments is mostly still symptomatic and aspecific while developments of new therapies are limited. A growing amount of data in the literature shows us how the prevalence of allergic diseases is different in both sexes and its changes over the course of life. Genes, hormones, environmental and immunological factors affect sex disparities associated with the development and control of allergic diseases, while they more rarely are considered and reported regarding their differences related to social, psychological, cultural, economic, and employment aspects. This review describes the available knowledge on the role of sex and gender in allergies in an attempt to improve the indispensable gender perspective whose potential is still underestimated while it represents a significant turning point in research and the clinic. It will offer insights to stimulate exploration of the many aspects still unknown in this relationship that could ameliorate the preventive, diagnostic, and therapeutic strategies in allergic diseases.

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Section: Urticariamentioning

confidence: 99%

Sex and Gender Aspects for Patient Stratification in Allergy Prevention and Treatment

Martinis

Sirufo

Suppa

et al. 2020

IJMS

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“…CD4 + T cells and mast cells in the skin lesions are also involved in the pathogenesis of AD . Mast cell activation mediated by IgE leads to a release of various chemical mediators, which results in infiltration of inflammatory cells such as eosinophils and lymphocytes into the skin lesion . Thus, the reduction in these cytokines and activation of immune cells can be effective for treatment of the skin diseases.…”

Section: Introductionmentioning

confidence: 99%

Anti‐inflammatory effect of astaxanthin in phthalic anhydride‐induced atopic dermatitis animal model

Park

Yeo

Han

et al. 2018

Experimental Dermatology

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In this study, we investigated anti-dermatitic effects of astaxanthin (AST) in phthalic anhydride (PA)-induced atopic dermatitis (AD) animal model as well as in vitro model. AD-like lesion was induced by the topical application of 5% PA to the dorsal skin or ear of Hos:HR-1 mouse. After AD induction, 100 μL of 1 mg/mL and 2 mg/mL of AST (10 μg or 20 μg/cm ) was spread on the dorsum of ear or back skin three times a week for four weeks. We evaluated dermatitis severity, histopathological changes and changes in protein expression by Western blotting for inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and nuclear factor-κB (NF-κB) activity. We also measured tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) and immunoglobulin E (IgE) concentration in the blood of AD mice by enzyme-linked immunosorbent assay (ELISA). AST treatment attenuated the development of PA-induced AD. Histological analysis showed that AST inhibited hyperkeratosis, mast cells and infiltration of inflammatory cells. AST treatment inhibited expression of iNOS and COX-2, and NF-κB activity as well as release of TNF-α, IL-1β, IL-6 and IgE. In addition, AST (5, 10 and 20 μM) potently inhibited lipopolysaccharide (LPS) (1 μg/mL)-induced nitric oxide (NO) production, expression of iNOS and COX-2 and NF-κB DNA binding activities in RAW 264.7 macrophage cells. Our data demonstrated that AST could be a promising agent for AD by inhibition of NF-κB signalling.

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“…Elevated production of serum IgE against many kinds of inhaled allergens and secretion of T helper (Th) 2 cytokines are the main causes of AD [2,3]. Mast cell activation mediated by IgE leads to a release of various chemical mediators which results in infiltration of inflammatory cells such as eosinophils and lymphocytes into the skin lesion [4]. CD4 + T cells and mast cells in the skin lesions are also involved in the pathogenesis of AD [5,6,7,8].…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Effect of Titrated Extract of Centella asiatica in Phthalic Anhydride-Induced Allergic Dermatitis Animal Model

Park

Choi

Son

et al. 2017

IJMS

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Centella asiatica has potent antioxidant and anti-inflammatory properties. However, its anti-dermatitic effect has not yet been reported. In this study, we investigated the anti-dermatitic effects of titrated extract of Centella asiatica (TECA) in a phthalic anhydride (PA)-induced atopic dermatitis (AD) animal model as well as in vitro model. An AD-like lesion was induced by the topical application of five percent PA to the dorsal skin or ear of Hos:HR-1 mouse. After AD induction, 100 μL of 0.2% and 0.4% of TECA (40 μg or 80 μg/cm2) was spread on the dorsum of the ear or back skin three times a week for four weeks. We evaluated dermatitis severity, histopathological changes and changes in protein expression by Western blotting for inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and NF-κB activity, which were determined by electromobility shift assay (EMSA). We also measured TNF-α, IL-1β, IL-6, and IgE concentration in the blood of AD mice by enzyme-linked immunosorbent assay (ELISA). TECA treatment attenuated the development of PA-induced atopic dermatitis. Histological analysis showed that TECA inhibited hyperkeratosis, mast cells and infiltration of inflammatory cells. TECA treatment inhibited expression of iNOS and COX-2, and NF-κB activity as well as the release of TNF-α, IL-1β, IL-6, and IgE. In addition, TECA (1, 2, 5 μg/mL) potently inhibited Lipopolysaccharide (LPS) (1 μg/mL)-induced NO production, expression of iNOS and COX-2, and NF-κB DNA binding activities in RAW264.7 macrophage cells. Our data demonstrated that TECA could be a promising agent for AD by inhibition of NF-κB signaling.

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Atopic dermatitis-like skin lesions with IgE hyperproduction and pruritus in KFRS4/Kyo rats

Abstract: Female KFRS4 rats have the potential to serve as an animal model of human AD.

Cited by 13 publications

References 30 publications

Sex and Gender Aspects for Patient Stratification in Allergy Prevention and Treatment

Sex and Gender Aspects for Patient Stratification in Allergy Prevention and Treatment

Anti‐inflammatory effect of astaxanthin in phthalic anhydride‐induced atopic dermatitis animal model

Anti-Inflammatory Effect of Titrated Extract of Centella asiatica in Phthalic Anhydride-Induced Allergic Dermatitis Animal Model

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