Atopic diseases in infancy. The German multicenter atopy study (MAS‐90)

Bergmann, Renate L.; Bergmann, Karl E.; Lau-Schadensdorf, S.; Luck, W. A. P.; Dannemann, A.; Bauer, Carl Peter; Dorsch, Walter; Förster, Johannes; Schmidt, Eberhard; Schulz, Jörn; Wahn, Ulrich

doi:10.1111/j.1399-3038.1994.tb00343.x

Cited by 200 publications

(139 citation statements)

References 24 publications

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“…The distributions of Ϫ401A allele frequency in the control populations were consistent with the expected Hardy-Weinberg equilibrium. All tested children were participants of the German Multicenter Allergy Study (MAS-90), a noninterventional, prospective, birth cohort study (14). Valid assessments of AD have not yet been performed in any of the other genotyped study populations.…”

Section: Frequency Of Mutant Allele and Association With Admentioning

confidence: 99%

“…Two hundred eighty-six unrelated children of the German Multicenter Allergy Study (MAS-90) (14) were genotyped; 188 subjects had been diagnosed with AD at two or more of five visits during the first 3 years of life and were compared with 98 control subjects (50 allergic, 48 nonallergic based on serum IgE Abs Ͼ0.35 kU/L to food or inhalant allergens). AD was defined as previously described (15).…”

Section: Study Populationsmentioning

confidence: 99%

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Atopic Dermatitis Is Associated with a Functional Mutation in the Promoter of the C-C Chemokine RANTES

Nickel

Casolaro

Wahn

et al. 2000

The Journal of Immunology

255

208

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Up-regulation of C-C chemokine expression characterizes allergic inflammation and atopic diseases. A functional mutation in the proximal promoter of the RANTES gene has been identified, which results in a new consensus binding site for the GATA transcription factor family. A higher frequency of this allele was observed in individuals of African descent compared with Caucasian subjects (p < 0.00001). The mutant allele was associated with atopic dermatitis in children of the German Multicenter Allergy Study (MAS-90; p < 0.037), but not with asthma. Transient transfections of the human mast cell line HMC-1 and the T cell line Jurkat with reporter vectors driven by either the mutant or wild-type RANTES promoter showed an up to 8-fold higher constitutive transcriptional activity of the mutant promoter. This is the first report to our knowledge of a functional mutation in a chemokine gene promoter. Our findings suggest that the mutation contributes to the development of atopic dermatitis. Its potential role in other inflammatory and infectious disorders, particularly among individuals of African ancestry, remains to be determined.

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Section: Frequency Of Mutant Allele and Association With Admentioning

confidence: 99%

Section: Study Populationsmentioning

confidence: 99%

Atopic Dermatitis Is Associated with a Functional Mutation in the Promoter of the C-C Chemokine RANTES

Nickel

Casolaro

Wahn

et al. 2000

The Journal of Immunology

255

208

View full text Add to dashboard Cite

show abstract

“…To keep the reporting bias low, parents kept a diary, recording details of all their children's illnesses. The study coordinators monitored the diary during the regular standardized physical examination by trained study physicians (10).…”

Section: Study Populationmentioning

confidence: 99%

Down-Regulation of IgE and IgG4 Antibodies to Tetanus Toxoid and Diphtheria Toxoid by Covaccination with Cellular Bordetella pertussis Vaccine

Grüber

Lau

Dannemann

et al. 2001

The Journal of Immunology

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Pertussis (P) toxin acts as adjuvant for IgE formation against simultaneously administered Ags in animal models. P vaccination may also have an adjuvant impact on IgE formation against coadministered diphtheria (D) and tetanus (T) Ags in humans. Sera of 103 D-T-P-immunized and 319 D-T-immunized children aged 2 years were analyzed for IgE, IgG4, and IgG to D and T (radioallergosorbent test), total IgE and IgE against common inhalant allergens (CAP radioallergosorbent test fluoroenzyme immunoassay). Fewer D-T-P- than D-T-immunized children had sera positive for T-IgE (12.6 vs 53.6%, p < 0.001), T-IgG4 (71.6 vs 89.2%, p < 0.001), D-IgE (31.0 vs 70.5%, p < 0.001), and D-IgG4 (85.2 vs 93.4%, p = 0.039). Suppression of T-IgE was not dependent on the cutoff chosen for a positive test result, but was dependent on the proportion of D-T immunizations given with P. The risk for sensitization to common environmental allergens did not differ (odds ratio 0.953, 95% confidence interval 0.815–1.114). No significant differences between D-T- and D-T-P-immunized children were found with regard to T-IgG or D-IgG. In summary, IgE and IgG4 (but not IgG) serum levels to coadministered D- and T-Ags are suppressed among P-immunized children as compared with nonimmunized children. These results suggest that the presence of a microbial product during Ag exposure can down-regulate an IgE/IgG4 response in humans.

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“…The asthma affair is a little more intricate: the onset within the first year is certain in 34,5% [23][24][25][26]-56,2% [24,27], of babies, but a higher level (82.4%) is evident between the 4th and the 7th year [24,[27][28][29]. That within the 8th year the asthma onset is manifest in 90% of children [28], is confirmed by the 92% proportion reached in patients less than 20 years of age [31]. As regards AR, the onset may be in the first year in 35% of children and in 59% of those aged 2-5 years [24], who in other studies are affected in 13-19% of cases [23,30].…”

Section: Discussionmentioning

confidence: 99%

In 250 Children we Demonstrate that the Transmission of Allergy and Asthma is Chiefly Genetic, Mainly when these Children are Asthmatic

Cantani¹

2015

Glob J Allergy

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There seems to be no unanimity of opinion as to the mode of transmission of allergic disease. According to some, allergy is transmitted as a simple Mendelian dominant. In direct contrast, others maintain that the findings favor a recessive mechanism. Further-more, others suggest that the condition is inherited as a "partial dominant" disorder. An additional analysis of family studies as well as data already published, failed to support either the simple dominant or recessive theory. The dominant theory does not explain why in more than half of the pedigrees both parents are normal. The recessive theory is refuted by the existence of pedigrees in which both parents are affected, yet some of the children are normal. To put more order in this complex mess, we have decided to study the genetic risk of children with a family history (FH) of allergy, We have therefore formed this prospective study in 250 children that included: family (FH) and personal history, skin prick tests (SPTs) and specific IgE (RAST), who were admitted to the Pediatric Allergy and Immunology Division of Rome University since they were affected with respiratory allergy. We have prepared a sheet with questions and possible answers. Consequently, we have studied the FH of these children asking whether their parents and brothers/sisters had atopic diseases, and specifying whether such disorders were respiratory or food allergies (FA). The parents of all children gave their informed consent. We analyzed data using the X2 method. 42.3% of their parents were atopic, as well as their 20 brothers/sisters. In total, 90.2% of fathers, 84% of mothers and 65% of brothers/sisters had asthma or allergic rhinitis (AR). We add that some parents had urticarial, further there were mothers and brothers/sisters experiencing atopic dermatitis (AD), and some mothers with food allergy (FA). In 23 children from these parents most had AD and respiratory allergy. In 250 children comparable for age and sex with no respiratory disorder supplied from our out patient clinic 40 parents, 14 mothers and 26 fathers and 9 brothers/sisters had asthma or AR (p = 0.0001), some fathers had also urticaria and two brothers AD. A major part of respiratory allergy is not transmitted by mothers: we stress that 42.3% of parents are atopic, and FH of their children was positive for respiratory allergy in 82-92% of cases. Thus respiratory allergy can have an autosomal dominant mode of inheritance, but considering the other atopic diseases, the transmission can be polygenic. The impact of genetic factors in these children is stressed by the relevant quote of asthmatic brothers/sisters. actual accordance between MZ and DZ twins [5]. Twin studies have also revealed a positive evidence for environmental influences, where unshared environmental influences appeared to be important [6]. Most printed studies in this domain have ascertained that everywhere between 40% and 70% of asthma heredity is preferable to hereditary factors [7]. We stress that several studies on asthma genetics have be...

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Atopic diseases in infancy. The German multicenter atopy study (MAS‐90)

Cited by 200 publications

References 24 publications

Atopic Dermatitis Is Associated with a Functional Mutation in the Promoter of the C-C Chemokine RANTES

Atopic Dermatitis Is Associated with a Functional Mutation in the Promoter of the C-C Chemokine RANTES

Down-Regulation of IgE and IgG4 Antibodies to Tetanus Toxoid and Diphtheria Toxoid by Covaccination with Cellular Bordetella pertussis Vaccine

In 250 Children we Demonstrate that the Transmission of Allergy and Asthma is Chiefly Genetic, Mainly when these Children are Asthmatic

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