Atopic eczema unresponsive to evening primrose oil (linoleic and γ-linolenic acids)

Skogh, M

doi:10.1016/s0190-9622(86)80146-3

Cited by 13 publications

(7 citation statements)

References 1 publication

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“…Accordingly, atopic dermatitis patients have insufficient levels of GLA in their skin, which contributes to the altered impermeability presenting as dry skin. Administration of GLA in atopic dermatitis patients, however, has not always been successful in the treatment of atopic dermatitis [4,5]. Although we could not retrospectively assess Yoon/Lee/Lee the clinical features of all patients included in the previous studies [4,5,7] that investigated the effect of EPO, there remains a possibility that heterogeneity in the clinical features of the patients involved in those studies would have led to the inconsistent results.…”

Section: Discussionmentioning

confidence: 97%

“…Administration of GLA in atopic dermatitis patients, however, has not always been successful in the treatment of atopic dermatitis [4,5]. Although we could not retrospectively assess Yoon/Lee/Lee the clinical features of all patients included in the previous studies [4,5,7] that investigated the effect of EPO, there remains a possibility that heterogeneity in the clinical features of the patients involved in those studies would have led to the inconsistent results. In this study, however, we selected patients mainly with itchy dry scaly skin without apparent erythema or oozing, who, we assumed, would yield better results in the treatment with EPO in view of the role of GLA to restore impermeability of the skin.…”

Section: Discussionmentioning

confidence: 97%

“…Accordingly, evening primrose oil (EPO) containing sufficient GLA has been tried in the treatment of atopic dermatitis [3]. Subsequent studies [4,5], however, failed to reveal a consistent effect and explicit mechanism of EPO in the treatment of atopic dermatitis. We assumed that this inconsistency might have resulted from the heterogeneity of patients with various clinical features included in the previous studies.…”

Section: Introductionmentioning

confidence: 99%

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The Therapeutic Effect of Evening Primrose Oil in Atopic Dermatitis Patients with Dry Scaly Skin Lesions Is Associated with the Normalization of Serum Gamma-Interferon Levels

Yoon

Lee

2001

Skin Pharmacol Physiol

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To see if evening primrose oil (EPO) could be more effective in a certain type of atopic dermatitis, we administered EPO to 14 atopic dermatitis patients characterized by itchy dry scaly skin. Furthermore, we measured serum levels of γ-interferon (IFN-γ) and IgE in addition to the clinical severity before and after the treatment to find out whether the treatment effect of EPO is related with an immunological mechanism. After the treatment, the extent of the skin lesions and the pruritus were markedly reduced in all patients. While serum IFN-γ levels were significantly increased (p < 0.01) after the treatment up to those of the normal control group, serum IgE levels showed a significant decrease (p < 0.05), failing to normalize completely. We concluded that EPO could be highly effective in the treatment of a grossly noninflammatory type of atopic dermatitis. The restoration of serum IFN-γ levels indicates that EPO might exert its effect through the modulation of the immunological mechanism involving IFN-γ.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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The Therapeutic Effect of Evening Primrose Oil in Atopic Dermatitis Patients with Dry Scaly Skin Lesions Is Associated with the Normalization of Serum Gamma-Interferon Levels

Yoon

Lee

2001

Skin Pharmacol Physiol

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“…Several RCTs of evening primrose oil have had mixed results, with the majority of data finding no benefit. 102-106 Two RCTs evaluating the use of oral borage oil in the treatment of atopic dermatitis did not show improvement in key outcomes compared with placebo. 107, 108 …”

Section: Dietary Interventionsmentioning

confidence: 99%

Guidelines of care for the management of atopic dermatitis

Sidbury

Tom

Bergman

et al. 2014

Journal of the American Academy of Dermatology

268

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“…Several studies done in this field show, although with discordant results, positive therapeutic effects on the AD severity after dietetic supplementary LA and AGL [13][14][15][16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Essential Fatty Acids in Neonates at Risk for Atopy

Cantani¹

2015

J Biomol Res Ther

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Essential fatty acids (EFA) are the major components of cellular phospholipids (PLs), contributing to their stability and functions. They are also precursors of inflammation mediators such as prostaglandins and leukotrienes, and are involved in cellular immunoregulation.Most recent studies have stressed that EFA levels are important in various diseases. Several Authors have stated that patients with atopic dermatitis (AD) have altered EFA levels in plasmatic PLs, and showed clinical improvement after oral EFA administration. The aim of our work was to study EFA composition of PLs of cord blood lymphocytes in 32 newborns at risk for atopy, in order to correlate EFA levels at birth with total IgE values and with the onset of atopic disease. Thirty not at risk newborns were studied as controls.Our results demonstrate a significant decrease (p<0.0001) of arachidonic acid (AA) levels in lymphocytes of newborns at risk for atopy, compared to controls, whereas a not significant increase of linoleic acid (LA) was present. No reverse correlation between IgE values and AA levels was found, whereas the 6 month and 1 year follow-up have not shown any major alteration of total IgE values, on the contrary a normalization of AA levels in all but one child has been observed. Only this one child has developed AD. We stress that the preventive action on allergy development recognized to breast milk could be also due to its effect on the EFA composition of the PLs of cell membrane.

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Atopic eczema unresponsive to evening primrose oil (linoleic and γ-linolenic acids)

Cited by 13 publications

References 1 publication

The Therapeutic Effect of Evening Primrose Oil in Atopic Dermatitis Patients with Dry Scaly Skin Lesions Is Associated with the Normalization of Serum Gamma-Interferon Levels

The Therapeutic Effect of Evening Primrose Oil in Atopic Dermatitis Patients with Dry Scaly Skin Lesions Is Associated with the Normalization of Serum Gamma-Interferon Levels

Guidelines of care for the management of atopic dermatitis

Assessment of the Essential Fatty Acids in Neonates at Risk for Atopy

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