Atopic endotype in childhood

Schoos, Ann‐Marie Malby; Chawes, Bo; Rasmussen, Morten Arendt; Bloch, Joakim; Bønnelykke, Klaus; Bisgaard, Hans

doi:10.1016/j.jaci.2015.10.004

Cited by 45 publications

(43 citation statements)

References 34 publications

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“…Thus far, all previous studies have shown that isolated late‐onset sensitization is not a risk factor for asthma . We have previously shown an association between any sensitization at 13 years and current asthma, but in this study, we found no association between late‐onset sensitization (sensitization only at 13 years) and current asthma, indicating that the persistent sensitization group is driving the former finding. It should, however, be noted that we found a borderline significant association between late‐onset sensitization diagnosed by sIgE and asthma ( P = .10), and the result should be interpreted with caution as the low number of cases with late‐onset sensitization (N = 27) may mask a true association (type II error).…”

Section: Discussioncontrasting

confidence: 87%

Single and multiple time‐point allergic sensitization during childhood and risk of asthma by age 13

Schoos

Jelding‐Dannemand

Stokholm

et al. 2019

Pediatric Allergy Immunology

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Background The relationship between allergic sensitization during childhood and risk of developing asthma remains unclear. Objective To analyze single time‐point and temporal patterns of sensitization in childhood in relation to asthma at age 13. Methods Specific IgE (sIgE) level and skin prick test (SPT) toward 22 food allergens and aeroallergens were assessed at 6, 18 months, 4, 6, and 13 years in children from the high‐risk Copenhagen Prospective Studies on Asthma in Childhood2000 (COPSAC2000) mother‐child cohort. We analyzed the association between single time‐point monosensitization, polysensitization, and quantitative assessment of sensitization, that is, sum of all sIgE levels and SPT wheal sizes, against asthma at age 13. In addition, we analyzed the association between three temporal patterns of sensitization: (a) early‐transient, (b) late‐onset, and (c) persistent sensitization and asthma. Results Polysensitization status measured by SPT or sIgE was at all single time‐points associated with increased risk of asthma at age 13: OR range, SPT = 3.0‐15.7, and sIgE = 2.6‐15.7, respectively, whereas monosensitization status was inconsistently associated with asthma. Quantitative assessment of both sIgE and SPT results was associated with asthma at all single time‐points: OR range, SPT = 1.3‐3.6, and sIgE = 1.1‐1.7. Persistent sensitization, but not early‐transient or late‐onset sensitization was associated with asthma by age 13: OR [95% CI], SPT = 8.9 [2.8‐28.23], and sIgE = 2.9 [1.1‐7.6], respectively. Conclusion Sensitization to multiple allergens at single time‐points, increasing sIgE levels and SPT wheal sizes, and persistent sensitization during childhood were associated with increased risk of asthma at age 13, suggesting the use of quantitative and repetitive sensitization measurements when assessing risk of developing asthma.

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Section: Discussioncontrasting

confidence: 87%

Single and multiple time‐point allergic sensitization during childhood and risk of asthma by age 13

Schoos

Jelding‐Dannemand

Stokholm

et al. 2019

Pediatric Allergy Immunology

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“…40 Asthma and atopy frequently coexist in children but this concordance decreases over time and does not prove that the asthma is due to the atopy. 41,42 In adults, asthma frequently occurs without atopy. 43 For these reasons, our finding of protective associations with early-life exposure predominantly for atopy, rather than asthma, may not be surprising.…”

Section: Discussionmentioning

confidence: 99%

Early-life farm exposures and adult asthma and atopy in the Agricultural Lung Health Study

House

Wyss

Hoppin

et al. 2017

Journal of Allergy and Clinical Immunology

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Background Previous studies, mostly from Europe, suggest that early-life farming exposures protect against childhood asthma and allergy; few data exist on asthma and allergy in adults. Objective We sought to examine associations between early-life farming exposures and current asthma and atopy in an older adult US farming population. Methods We analyzed data from 1746 farmers and 1555 spouses (mean age, 63) from a case-control study nested within the Agricultural Health Study. Current asthma and early-life farming exposures were assessed via questionnaires. We defined atopy based on specific IgE > 0.70 IU/mL to at least 1 of 10 allergens measured in blood. We used logistic regression, adjusted for age, sex, race, state (Iowa or North Carolina), and smoking (pack years), to estimate associations between early-life exposures and asthma (1198 cases and 2031 noncases) or atopy (578 cases and 2526 noncases). Results Exposure to the farming environment in utero and in early childhood had little or no association with asthma but was associated with reduced odds of atopy. The strongest association was seen for having a mother who performed farm activities while pregnant (odds ratio, 0.60; 95% CI, 0.48–0.74) and remained significant in models with correlated early-life exposures including early childhood farm animal contact and raw milk consumption. Conclusions In a large US farming population, early-life farm exposures, particularly maternal farming activities while pregnant, were strongly associated with reduced risk of atopy in adults. These results extend previous work done primarily on childhood outcomes and suggest that protective associations of early-life farming exposures on atopy endure across the life course.

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“…The manifestations may present in a characteristic sequence in children that has been named the atopic or allergic march [2]. Although the atopic march is highly controversial and only a minority of patients follow this march [3], the first signs of atopic diseases are usually food allergy and atopic dermatitis. As these signs of atopic disease are often observed in the first 3 years of life and are thought to be related to the maturation of the immune system [2].…”

Section: Introductionmentioning

confidence: 99%

A Systematic Review of the Prevalence of Atopic Diseases in Children on the Arabian Peninsula

Al‐Herz

2018

Med Princ Pract

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Objectives: To study the available data on the prevalence of atopic diseases and food allergy in children living on the Arabian Peninsula. Methods: A PubMed search for relevant published articles was conducted using the following search terms singly or in combination: “atopy,” “atopic disease,” “atopic disorder,” “International Study of Asthma and Allergies in Childhood,” “ISAAC,” “asthma,” “allergic rhinitis,” “eczema,” and “food allergy” in combination with the names of countries of the Arabian Peninsula (Kuwait, United Arab Emirates, Bahrain, Qatar, Oman, Kingdom of Saudi Arabia, and Yemen). The search captured studies published up to December 2017. Results: A total of 8 publications reporting prevalence rates of any type of atopic disease in children in 7 countries of the Arabian Peninsula were retrieved. The prevalence of all atopic disorders was comparable between countries of the Arabian Peninsula. The overall prevalence of asthma ranged from 8 to 23%, while the reported prevalence of eczema ranged from 7.5 to 22.5%. There was great variation in the prevalence rates of rhinoconjunctivitis, which ranged from 6.3 to 30.5%. The prevalence of food allergy (8.1%) was reported for 1 country only, the United Arab Emirates. Conclusions: The reported overall rates of atopic disease in countries of the Arabian Peninsula are comparable to those reported in other industrialized countries. This is probably related to the good economic status in the region, which is reflected in the living standards and lifestyle. Further, genetic factors, such as factors related to gene polymorphism, and the high rate of consanguinity in the region may contribute to the higher prevalence of atopic diseases.

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Atopic endotype in childhood

Cited by 45 publications

References 34 publications

Single and multiple time‐point allergic sensitization during childhood and risk of asthma by age 13

Single and multiple time‐point allergic sensitization during childhood and risk of asthma by age 13

Early-life farm exposures and adult asthma and atopy in the Agricultural Lung Health Study

A Systematic Review of the Prevalence of Atopic Diseases in Children on the Arabian Peninsula

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