Atopic March to a Dead End or Does the Theory Really Have Legs?

Curtiss, Frederic R.

doi:10.18553/jmcp.2007.13.9.810

Cited by 6 publications

(4 citation statements)

References 6 publications

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“…60 This provides a paradigm shift for focusing on tissue–specific predisposition that may apply to other disorders, which may help to explain gaps in our understanding of the “atopic march” theory. 60,303 Systematic integration of “big data” coming from providers (e.g., EMR), from omics (e.g., genomic, proteomic, epigenomic, metabolomic), and from multi-ethnic patients and non-providers (e.g., smart phone, monitoring tools for environmental triggers) can thus provide valuable insights to resolve the clinical complexity and ancestry-specific (or shared) etiology of atopic disorders.…”

Section: Resultsmentioning

confidence: 99%

Resolving the etiology of atopic disorders by using genetic analysis of racial ancestry

Gupta

Johansson

Bernstein

et al. 2016

Journal of Allergy and Clinical Immunology

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Atopic dermatitis (AD), food allergy (FA), allergic rhinitis (AR) and asthma are common atopic disorders of complex etiology. The frequently observed “atopic march” from early AD to asthma and/or AR later in life as well as the extensive comorbidity of atopic disorders, suggests common causal mechanisms in addition to distinct ones. Indeed, both disease-specific and shared genomic regions exist for atopic disorders. Their prevalence also varies among races; for example, AD and asthma have a higher prevalence in African-Americans when compared to European-Americans. Whether this disparity stems from true genetic or race-specific environmental risk factors or both is unknown. Thus far, the majority of the genetic studies on atopic diseases have utilized populations of European ancestry, limiting their generalizability. Large cohort initiatives and new analytic methods such as admixture mapping are currently being employed to address this knowledge gap. Here we discuss the unique and shared genetic risk factors for atopic disorders in the context of ancestry variations, and the promise of high-throughput “-omics” based systems biology approach in providing greater insight to deconstruct into their genetic and non-genetic etiologies. Future research will also focus on deep phenotyping and genotyping of diverse racial ancestry, gene-environment, and gene-gene interactions.

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Section: Resultsmentioning

confidence: 99%

Resolving the etiology of atopic disorders by using genetic analysis of racial ancestry

Gupta

Johansson

Bernstein

et al. 2016

Journal of Allergy and Clinical Immunology

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“…The exact relationship between early eczema and subsequent development of sensitization, asthma and hay fever is not clear (26, 27). A disturbed barrier function of the skin because of FLG gene mutations may enable allergens to penetrate into the skin, which may contribute to the development of systemic allergic conditions such as sensitization, asthma and hay fever.…”

Section: Discussionmentioning

confidence: 99%

Filaggrin mutations in the onset of eczema, sensitization, asthma, hay fever and the interaction with cat exposure

Schuttelaar¹,

Kerkhof

Jonkman³

et al. 2009

Allergy

127

106

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“…As mentioned above, it is important to point out that although this progression is noted in individual patients, debate exists on the evidence of this phenomenon. Some publications have questioned the existence of an actual atopic march [38,39] while more recent studies have provided renewed support of an actual temporal pattern of progression from eczema to allergic rhinitis and asthma and a correlation between early eczema and childhood asthma [40][41][42].…”

Section: Atopic Dermatitis: Comparative Observationsmentioning

confidence: 99%

Animal Models of Allergic Diseases

Santoro

Marsella

2014

Veterinary Sciences

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Allergic diseases have great impact on the quality of life of both people and domestic animals. They are increasing in prevalence in both animals and humans, possibly due to the changed lifestyle conditions and the decreased exposure to beneficial microorganisms. Dogs, in particular, suffer from environmental skin allergies and develop a clinical presentation which is very similar to the one of children with eczema. Thus, dogs are a very useful species to improve our understanding on the mechanisms involved in people's allergies and a natural model to study eczema. Animal models are frequently used to elucidate mechanisms of disease and to control for confounding factors which are present in studies with patients with spontaneously occurring disease and to test new therapies that can be beneficial in both species. It has been found that drugs useful in one species can also have benefits in other species highlighting the importance of a comprehensive understanding of diseases across species and the value of comparative studies. The purpose of the current article is to review allergic diseases across species and to focus on how these diseases compare to the counterpart in people.

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Atopic March to a Dead End or Does the Theory Really Have Legs?

Cited by 6 publications

References 6 publications

Resolving the etiology of atopic disorders by using genetic analysis of racial ancestry

Resolving the etiology of atopic disorders by using genetic analysis of racial ancestry

Filaggrin mutations in the onset of eczema, sensitization, asthma, hay fever and the interaction with cat exposure

Animal Models of Allergic Diseases

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