Atopy as a risk factor for the development of asthma in young recruits

Moshe, Shlomo; Slodownik, Dan; Yagev, Yaron; Segal, N; Tavor, Michal; Afek, Arnon; Zack, Oren

doi:10.3109/02770903.2014.982287

Cited by 5 publications

(3 citation statements)

References 26 publications

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“…There is a consecutive process in the progression of AR into asthma, as previously demonstrated by a long-term follow-up study (22). This has also been confirmed through a retrospectively study (23,24). The present results showed that the mean duration of AR was longer than asthma in the AR with asthma group, although certain patients reported that asthma was diagnosed earlier than AR.…”

Section: Discussionsupporting

confidence: 88%

FeNO for detecting lower airway involvement in patients with allergic rhinitis

Zhu

Xie

Guan

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. Allergic rhinitis (AR) is a risk factor for asthma development. The value of fractional exhaled nitric oxide (FeNO) in detecting lower airway involvement in the progress of AR-asthma march has not been evaluated. The aim of the present study was to investigate the value of FeNO in assessing lower airway inflammation and predicting bronchial hyperresponsiveness (BHR) in AR with or without asthma. FeNO and eosinophil count in induced sputum, and a methacholine bronchial provocation test were performed in 93 subjects, including: 45 AR patients (AR group); 20 patients with AR and asthma (AR with asthma group); and 28 normal controls (control group). The AR group was divided into two sub-groups: AR with asymptomatic BHR group and AR without BHR group. Correlation between FeNO and eosinophil count was assessed. Receiver operating characteristic (ROC) curve was applied to evaluate the predictive and diagnostic value of FeNO in detecting BHR. The values of FeNO in the AR and AR with asthma groups were higher [29.5 (22.0) ppb and 61.5 (33.0) ppb] compared with the normal control group (16.0 (10.0) ppb), where the values in brackets indicate the interquartile range of the values. The percentages of eosinophils in induced sputum were 2.43±3.56, 7.36±4.98 and 18.58±11.26% in the control, AR and AR with asthma groups, respectively. For the diagnosis of BHR, the area under the curve (AUC) was 0.910 (95%CI 0.836, 0.984), with the sensitivity and specificity 0.846 and 0.817 when the cut-off value takes 31.5 ppb. For diagnosis of asthma, the AUC was 0.873 (95%CI 0.753, 0.992) with sensitivity 0.857 and specificity 0.847 when taking the cut-off value to be 38.0 ppb. The value of FeNO was well correlated with eosinophil count in the sputum. The measurement of FeNO is an effective method in detecting lower airway involvement in AR developing to asthma.

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Section: Discussionsupporting

confidence: 88%

FeNO for detecting lower airway involvement in patients with allergic rhinitis

Zhu

Xie

Guan

et al. 2016

Experimental and Therapeutic Medicine

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“…We found a total of 29 eligible studies, including 22 cohort studies and 7 case-control studies with a total of 274,489 subjects 6, 7, 8, 9, 11, 12, 15, 16, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45…”

Section: Resultsmentioning

confidence: 99%

“…(2018) 40 SpainCohort of schoolchildren in Castellón, Spain44/128010613–15 years10 years4.05 (1.71–9.60)Age, sex, family history asthma, family history of allergic rhinitis, history of respiratory diseases, breastfeeding, living place, passive smoking, mother's age at time of birth, and pet at homeMoshe et al. (2015) 41 IsraelAll-male Israel Defense Forces (IDF)a1984/128591489118–21 years3 years1.86 (1.57–2.21)SexTormanen et al. (2018) 42 FinlandCohort of infant hospitalized for bronchiolitis18/13839less than 6 months11–13 years4.06 (1.35–12.25)Age, maternal asthma, maternal allergy, parental asthma, paternal allergy, maternal and paternal smokingCarr et al.…”

Section: Resultsmentioning

confidence: 99%

History of allergic rhinitis and risk of asthma; a systematic review and meta-analysis

Tohidinik

Mallah

Takkouche

2019

World Allergy Organization Journal

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BackgroundAllergic rhinitis has been suspected to be a risk factor for asthma in several studies but this association is not firmly established. The objective of this study was to synthesize the evidence of the association between allergic rhinitis and the risk of asthma through a systematic review and meta-analysis.MethodsWe performed a search in Medline, Scopus, ISI Proceedings databases and other databases from inception until February 2019, followed by manual search to identify potentially relevant case-control and cohort studies that reported relative risk estimates and confidence intervals of the association between allergic rhinitis and asthma. Cross-sectional studies were excluded. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using fixed and random effects models and quality of studies was assessed through a modified version of the Newcastle-Ottawa scale.ResultsTwenty-nine eligible studies, 22 cohort and 7 case-control studies, with a total of 274489 subjects, were included in the meta-analysis. The results show that history of allergic rhinitis is significantly associated with the occurrence of asthma (OR = 3.82; 95% CI: 2.92–4.99). European studies showed a stronger association (OR = 4.35; (95% CI: 3.12–6.06) than non-European studies (OR = 2.75; 95% CI: 2.16–3.50), and case-control studies showed a stronger association (OR = 4.71; 95% CI: 3.58–6.17) than cohort studies (OR = 3.42; 95% CI: 2.60–4.50).ConclusionsThis meta-analysis shows that allergic rhinitis is strongly associated with asthma. Further prospective studies on the effect of treatment of allergic rhinitis on the development of asthma are needed. Relief of airway allergic manifestations may need dual control of allergic rhinitis and asthma.RegistrationPROSPERO database with registration number CRD42017055156.

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