Atopy, symptoms and indoor environmental perceptions, tear film stability, nasal patency and lavage biomarkers in university staff

Bakke, Jan Vilhelm; Wieslander, Gunilla; Norbäck, Dan; Moen, Bente E.

doi:10.1007/s00420-007-0280-2

Cited by 30 publications

(20 citation statements)

References 49 publications

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“…With regard to moving into a newly built house, studies in Japan have recently identified chemical substances emitted from indoor building materials, such as formaldehyde and volatile organic compounds as major causes of sick building syndrome [28,29]. These chemicals may thus increase the risk of allergic disease [30] and several studies reported a correlation between AD and sick building syndrome [31,32]. …”

Section: Discussionmentioning

confidence: 99%

Exposure to Gene-Environment Interactions before 1 Year of Age May Favor the Development of Atopic Dermatitis

Lee¹,

Seo²,

Kwon

et al. 2011

Int Arch Allergy Immunol

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Background: The aims of this study were to determine (1) the prevalence of atopic dermatitis (AD) in Seoul, Korea, and (2) the influence of environmental and genetic factors on disease risk. Methods: A questionnaire survey was conducted in 5,036 primary school children and 4,607 middle school children in 2008. For each child, a modified version of the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire and a questionnaire assessing exposure to environmental variables were completed. Results: In primary school children, the lifetime prevalence of itchy eczema was 24.3%, the 12-month prevalence of itchy flexural eczema was 18.0%, the lifetime prevalence of AD diagnosis was 31.3%, and the 12-month prevalence of AD treatment was 14.5%. In middle school children, the corresponding rates were 16.0, 10.8, 22.1, and 8.3%, respectively. These rates are significantly higher than those reported in similar studies conducted in 1995 and 2000. In both primary and middle school children, a parental history of allergic disease and a history of having moved into a newly built house before 1 year of age were independently associated with a risk for current AD. For current AD, the prevalence odds ratio was higher in the subgroup with both a genetic and a specific environmental risk factor than in the subgroup with no risk factor or subgroups with only one risk factor. Conclusions: The prevalence of AD in primary and middle school children in Seoul has increased. Its development may be influenced by gene-environment interactions, particularly before 1 year of age.

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Section: Discussionmentioning

confidence: 99%

Exposure to Gene-Environment Interactions before 1 Year of Age May Favor the Development of Atopic Dermatitis

Lee¹,

Seo²,

Kwon

et al. 2011

Int Arch Allergy Immunol

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“…Moreover, unbalanced psychosocial work environment (Marmot et al, 2006;Runeson et al, 2006) and occupational stress (Azuma et al, 2014;Bakke et al, 2007) have been shown to be related to SBS symptoms. Indoor environmental factors associated with SBS include room temperature (Bakke et al, 2008), relative air humidity (Wolkoff, 2008), building dampness (Mendell et al, 2011;Park et al, 2008), ventilation flow (Seppänen and Fisk, 2004;Sundell et al, 2011), microbial exposure such as molds and bacteria (WHO, 2009), microbial volatile organic compounds (MVOC) (Araki et al, 2010;Sahlberg et al, 2013) and volatile organic compounds (VOC) (Takigawa et al, 2012).…”

mentioning

confidence: 99%

Sick building syndrome (SBS) among office workers in a Malaysian university — Associations with atopy, fractional exhaled nitric oxide (FeNO) and the office environment

Lim

Hashim

Said

et al. 2015

Science of The Total Environment

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“…They include food intolerance, unexplained episodes of fever, allergies, urticaria or angioedema, skin sensitivity to sunlight, oral ulcerations, inflammation in distal joints or livedo reticularis. These associations can support an immunologic mechanism for SBS [17,18]. A multivariate score for predicting the RC's Disease has been constructed; such a score requires further validation in independent samples before it can be considered applicable in other places.…”

Section: Discussionmentioning

confidence: 99%

Investigating an outbreak of non-specific building-related symptoms in workers of a general hospital

Gómez‐Acebo¹,

Dierssen-Sotos²,

Pérez-Belmonte³

et al. 2013

International Journal of Occupational Medicine and Environmental Health

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Objective: To obtain a case definition and to describe variables associated with a cluster of unspecific symptoms in healthcare workers (HCW) in a hospital building. Materials and Methods: A cross-sectional study was performed. All people working at the Residencia Cantabria building (a 200-bed building belonging to University Hospital Marqués de Valdecilla) in June 2009 were invited to complete a self-administered questionnaire, including questions on demographic data, working place and shift, working conditions and current symptoms. A cluster analysis was developed to obtain the case definition. The strength of the association between the studied variables and accomplishing the case definition was measured using odds ratios (OR) with the 95% confidence interval (CI). Multiple logistic regression was used to obtain a predictive model; its general validity was estimated with Receiver Operating Curves (ROC) and their Area Under the Curve (AUC). Results: 357 completed questionnaires were obtained. The case was defined as having at least 5 symptoms out of the eleven included. Not being ascribed to a specific shift was the strongest protective variable related with "being a case" (OR = 0.30; 95% CI: 0.17-0.54), whereas the personal antecedent of distal pain or inflammation in arms or legs was the main risk factor (OR = 4.33, 95% CI: 2.75-6.82). A six-variable predictive model has AUC equaling to 0.7378. Conclusions: A disease associated with the indoor environment quality in a hospital was characterized. A multivariate score was drafted for identifying HCW with higher risk of developing the disease in order to apply administrative prevention measures.

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Atopy, symptoms and indoor environmental perceptions, tear film stability, nasal patency and lavage biomarkers in university staff

Cited by 30 publications

References 49 publications

Exposure to Gene-Environment Interactions before 1 Year of Age May Favor the Development of Atopic Dermatitis

Exposure to Gene-Environment Interactions before 1 Year of Age May Favor the Development of Atopic Dermatitis

Sick building syndrome (SBS) among office workers in a Malaysian university — Associations with atopy, fractional exhaled nitric oxide (FeNO) and the office environment

Investigating an outbreak of non-specific building-related symptoms in workers of a general hospital

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