Atorvastatin exhibits anti-inflammatory and anti-oxidant properties in adjuvant-induced monoarthritis

Kumar, Vijay; Guruprasad, B.; Wahane, V.D.

doi:10.1007/s10787-010-0057-1

Cited by 17 publications

(7 citation statements)

References 30 publications

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“…The inhibition of prostaglandin E 2 (PGE 2 ) suggests a direct antinociceptive action of simvastatin on nociceptors in peripheral sites similar to that of diclofenac, metamizol or morphine [22]. Supporting this assumption, other studies reported an anti‐inflammatory effect for atorvastatin, comparable to that of diclofenac [23,24]. Furthermore, another explanation for the findings of this work could be the up‐regulation of iNOS expression induced by statins through inhibition of small G protein of the Rho family [25].…”

Section: Discussionsupporting

confidence: 53%

Antinociception and Anti-Inflammation Induced by Simvastatin in Algesiometric Assays in Mice

Miranda¹,

Noriega²,

Olavarría³

et al. 2011

Basic &Amp; Clinical Pharmacology &Amp; Toxicology

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Statins, belonging to a well-known drug class used for lowering cholesterol through competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, also have other pleiotropic properties, such as anti-inflam-matory action. The purpose of this study was to evaluate the antinociceptive and anti-inflammatory effects of simvastatin in five models of nociceptive behaviour. Oral gavage administration of simvastatin induced a dose-dependent inhibition of noci-ception for 1 day in the acetic acid writhing (ED 50 = 5.59 € 0.07), tail-flick (ED 50 = 112.96 € 8.00), hot-plate (ED 50 = 134.87 € 2.20), formalin hind paw (ED 50 = 19.86 € 1.12 in phase I and 23.30 € 2.05 in phase II) and orofacial formalin (ED 50 = 5.54 € 2.74 in phase I and 11.48 € 1.88 in phase II) tests. However, after 3 days, the values were in the acetic acid writhing (ED 50 = 6.14 € 0.51), tail-flick (ED 50 = 154 € 8.88), hot-plate (ED 50 = 136.14 € 2.94), formalin hind paw (ED 50 = 15.93 € 0.42 in phase I and 17.10 € 1.80 in phase II) and orofacial formalin (ED 50 = 6.79 € 0.66 in phase I and 5.80 € 1.49 in phase II) tests. This study demonstrated the antinociceptive and anti-inflammatory activities of simvastatin in five models of tonic or phasic pain. These actions seem to be related to the inhibition of cytokine and prostanoid release and stimulation of nitric oxide synthesis. A possible clinical role of simvastatin could be related to the potentially beneficial effects in the neuropathic pain, and by their pleiotropic properties, they could play a clinical role in anti-inflammatory disease. Statins, a well-known drug class used for lowering cholesterol through competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, also have other pleio-tropic properties, including a slight anti-inflammatory action. Although all statins share a common mechanism of action, they differ in terms of their chemical structures, pharmacoki-netic profiles and lipid-modifying efficacy. The overall conclusion of the recent JUPITER trial study was that statins had anti-inflammatory properties independent of their ability to lower cholesterol [1]. Animal models reveal consistent findings of the anti-inflammatory effects of statins. Simvastatin, in a model of collagen-induced arthritis in mice, demonstrated significant anti-inflammatory activity [2]. The daily oral administration of atorvastatin inhibited the increase in hind paw volume and inflammatory hypernociception in the adjuvant-induced arthritis assay in rats [3]. Atorvastatin produced an antinociceptive effect in two different models of mechanical inflammatory hypernociception in mice [4]. Simvastatin reduced the inflammatory process and the dopaminergic degeneration induced by the intrani-gral injection of a lipopolysaccharide in rats [5]. A significant decrease in the analgesic and anti-inflammatory activities was induced by atorvastatin and rosuvastatin in mice and rats [6]. It is important to note that, although the anti-inflamma-tory properties of statins are consis...

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Section: Discussionsupporting

confidence: 53%

Antinociception and Anti-Inflammation Induced by Simvastatin in Algesiometric Assays in Mice

Miranda¹,

Noriega²,

Olavarría³

et al. 2011

Basic &Amp; Clinical Pharmacology &Amp; Toxicology

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“…In this study, the OVA-challenged animals demonstrated high cellular infiltrate in their bronchial trees, an effect that was significantly reduced by early Atorvastatin treatment. This effect may be related to the anti-inflammatory or the anti-oxidant properties of Atorvastatin previously shown [21,22].…”

Section: Discussionmentioning

confidence: 80%

Study of Atorvastatin in experimental allergic airway inflammation in mice

Rahman

Abdelmotelb

2011

International Immunopharmacology

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“…However, the antioxidant and antiinflammatory properties of statins have been known for years. A dose-dependent reduction and normalization of oxidative stress marker levels in joint inflammation has been reported after atorvastatin administration (5). In a recent meta-analysis of 8 randomized trials, the use of short-term statins was associated with a reduction in the incidence of contrast-induced nephropathy, and was recommended even in patients with low LDLcholesterol levels (6).…”

Section: Introductionmentioning

confidence: 99%

The reno-protective effects of atorvastatin in crush syndrome and rhabdomyolysis:is there a dilemma?

Acar¹,

Gülpembe²,

Yıldız³

et al. 2017

Turk J Med Sci

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Background/aim: We aim to determine the effects of low-dose atorvastatin treatment together with crush fluid resuscitation on renal functions and muscle enzyme levels in a rat model of crush syndrome. Materials and methods:The study involved female Wistar Albino rats weighing 250-300 g that were housed with free access to food and water. The crush model was obtained by compression. Rats were randomly divided into four groups: control (C) group, atorvastatin + crush fluid (ACF) group, crush fluid (CF) group, and hypertonic saline (%3) + mannitol + sodium bicarbonate (SM) group. Blood was obtained at 24, 48, and 72 h, and serum creatinine kinase, myoglobin, urea, creatinine, and lactate dehydrogenase levels were studied.Results: All parameters were statistically significantly higher in the control group than in the treatment groups at all hours. However, there was no statistically significant difference among treatment groups regarding any of the parameters. Conclusion:This is the first study determining the role of atorvastatin in the treatment of renal ischemia/reperfusion injury in a crush syndrome and rhabdomyolysis model setting. Larger studies with different atorvastatin doses are required to define the role of this drug in the treatment of renal ischemia/reperfusion injury during crush syndrome.

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Atorvastatin exhibits anti-inflammatory and anti-oxidant properties in adjuvant-induced monoarthritis

Cited by 17 publications

References 30 publications

Antinociception and Anti-Inflammation Induced by Simvastatin in Algesiometric Assays in Mice

Antinociception and Anti-Inflammation Induced by Simvastatin in Algesiometric Assays in Mice

Study of Atorvastatin in experimental allergic airway inflammation in mice

The reno-protective effects of atorvastatin in crush syndrome and rhabdomyolysis:is there a dilemma?

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