2023
DOI: 10.21203/rs.3.rs-3121720/v1
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Atorvastatin improves intestinal mucositis induced by 5-fluorouracil in mice by modulating the and epithelial barrier and inflammatory signaling pathways

Abstract: Chemotherapy-induced intestinal mucositis is a major side effect of cancer treatment. Statins are 3-hydroxy-3-methyl glutaryl coenzyme reductase inhibitors used to treat hypercholesterolemia and atherosclerotic diseases. Recent studies have demonstrated that atorvastatin (ATV) has antioxidant, anti-inflammatory, and resulting from the regulation of different molecular pathways. In the present study, we investigated the effects of ATV on intestinal homeostasis in 5-fluorouracil (5-FU)-induced mucositis. Our res… Show more

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