Atorvastatin improves pathological changes in the aged kidney by upregulating peroxisome proliferator-activated receptor expression and reducing matrix metalloproteinase-9 and transforming growth factor-β1 levels

Zhao, Jiahui; Cheng, Qingli; Yang, Guang; Liu, Sheng; Ao, Qiangguo; Liu, Yang; Hu, Yazuo

doi:10.1016/j.exger.2015.12.004

Cited by 16 publications

(15 citation statements)

References 18 publications

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“…The mechanism of angiogenesis stimulated by TGF-β signaling includes the induction of key angiogenic factors, including connective tissue growth factor, vascular endothelial growth factor and insulin-like growth factor-binding protein 7, in epithelial cells and fibroblasts (64,65). In addition, TGF-β can induce the expression, secretion and activation of matrix metalloproteinase 2 (MMP2) and MMP9 and down regulate the expression of tissue inhibitor of metalloproteinase in tumor and endothelial cells (66)(67)(68).…”

Section: Tgf-β Signaling In the Regulation Of Tumor Angiogenesismentioning

confidence: 99%

TGF‑β signaling: A complex role in tumorigenesis (Review)

2017

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Tumor progression can be affected by various cellular components of tumor cells and/or by tumor microenvironmental factors. The tumor microenvironment comprises a variety of nonmalignant stromal cells and inflammatory cytokines, which are pivotal in tumor promotion and progression. The transforming growth factor‑β (TGF‑β) ligands (TGF‑β1, 2 and 3) are secreted inflammatory cytokines, which are known to be involved in various aspects of tumor development through two transmembrane serine‑threonine kinase receptors, TGFβR1 and TGFβR2. TGF‑β promotes or inhibits tumorigenesis depending on the concurrent gene mutations and tissue microenvironment present through the small mothers against decapentaplegic (Smad) and non‑Smad pathways. This review aims to provide a comprehensive overview of the role of the TGF‑β pathway in tumor initiation and progression.

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Section: Tgf-β Signaling In the Regulation Of Tumor Angiogenesismentioning

confidence: 99%

TGF‑β signaling: A complex role in tumorigenesis (Review)

2017

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“…Going with, glomerular atrophy and collapse were reported in aged rats [29] . It was stated stated that the rat renal corpuscle diameter continuously increased from age 3 to 30 months [30] and the incidence of glomerulosclerosis was confirmed in 20 months aged rats [31] . In human, it was stated that glomerulosclerosis may develop in the kidney with age progression [32] .…”

Section: Discussionmentioning

confidence: 98%

Sexual Dimorphism in Relation to Structural Changes in Renal Cortex in Different Age Groups: Possible Role of Endogenous SCs

Zickri

Hamoud

2019

Egyptian Journal of Histology

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Background: Chronic kidney disease (CKD) is an inevitable process which might be the major cause of death in senile age. In certain diseases male gender is a risk factor. The mitotic division of resident SCs might be stimulated by cellular injury and contribute to the restoration of damaged cells. Aim of study: The current study is designed to study the sexual dimorphism in relation to structural changes in the renal cortex in prepubertal, pubertal and postpubertal age groups of rat. In addition, possible role of endogenous stem cells (SCs). Materials and methods: Thirty albino rats were divided into three groups, Pre-pubertal, pubertal and post-pubertal each was subdivided into two subgroups male and female respectively. The body weight (BW), kidney weight (KW), cross sectional area (CA) and serum creatinine (sC) were determined. Kidney sections were subjected to histological, histochemical, immunohistochemical, morphometric and statistical studies. Results: BW and glomerular area values recorded age related changes. While KW, CA, sC, count of dark nuclei, area of collagen, thickness of tubular basement membrane, count of proliferation marker proved age and sex related changes. Conclusion: Progressive age related increase in BW, KW, CA, sC and glomerular area (GA) was found, that became reciprocal for the GA in postpubertal rats due to atrophy. Elevated sC, enhanced apoptosis, fibrosis and thickened tubular basement membrane (tBM) and reduced cellular proliferation were detected. Enhanced SCs migration in response to injury were more noticeable in male postpubertal rats.

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“…One relevant mechanism may be by PPARs, nuclear receptors that participate in cellular lipid homeostasis and insulin action [33]. PPARs are also transcriptional activators of genes encoding enzymes to metabolize fatty acid in the liver as well as other metabolic tissues [34] and atorvastatin has been demonstrated to exert cardiac protective influences by pronouncedly up-regulating PPARs expression [35–37]. In our research, relative protein expression of PPARs and phosphorylated PPARs (Additional file 1) were observed in 3 T3-L1 adipocytes and adipose tissues of hamsters, thereby investigating the potential mechanism of XH601.…”

Section: Discussionmentioning

confidence: 99%

Hypolipidemic effect of XH601 on hamsters of Hyperlipidemia and its potential mechanism

et al. 2017

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BackgroundThe novel compound XH601 is a synthesized derivative of formononetin. The present study was to investigate the hypolipidemia effect and potential mechanism of XH601.MethodsMale Golden Syrian hamsters were induced by high-fat diet (HFD) for eight weeks and the hyperlipidemic model was established successfully. After XH601 treatment, serum and hepatic biochemistry parameters of hamsters were detected and the effect of XH601 on adipose tissue was also analyzed. Furthermore, 3 T3-L1 cell differentiation by Oil-Red-O staining was observed and the mRNA and protein expression of peroxisome proliferator-activated receptors (PPARs) were measured by qRT-PCR and Western-blot in mature adipocytes.ResultsThe in vivo results suggest that XH601 significantly decreased the adipose weight and levels of serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL-C), apolipoprotein B (Apo-B), apolipoprotein E (Apo-E), while increased serum high-density lipoprotein (HDL-C). The in vitro results implied that XH601 up-regulated the mRNA and protein expression of both PPARα and PPARβ/δ in a dose-dependent manner.ConclusionsThe study suggests that XH601 exhibited strong ability to improve the dyslipidemia in hamsters fed with high-fat diet. The potential mechanism of XH601 was associated with the up-regulation of PPARα and PPARβ/δ mRNA and protein expression.Electronic supplementary materialThe online version of this article (doi:10.1186/s12944-017-0472-z) contains supplementary material, which is available to authorized users.

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Atorvastatin improves pathological changes in the aged kidney by upregulating peroxisome proliferator-activated receptor expression and reducing matrix metalloproteinase-9 and transforming growth factor-β1 levels

Cited by 16 publications

References 18 publications

TGF‑β signaling: A complex role in tumorigenesis (Review)

TGF‑β signaling: A complex role in tumorigenesis (Review)

Sexual Dimorphism in Relation to Structural Changes in Renal Cortex in Different Age Groups: Possible Role of Endogenous SCs

Hypolipidemic effect of XH601 on hamsters of Hyperlipidemia and its potential mechanism

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