Atorvastatin-induced Lichenoid Drug Eruption: A Case Report and Review of Statin-associated Cutaneous Adverse Events

Forouzan, Parnia; Riahi, Ryan R; Cohen, Philip R.

doi:10.7759/cureus.7155

Cited by 10 publications

(12 citation statements)

References 16 publications

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“…Oral lichenoid drug eruptions are extremely rare and challenging in diagnosis. 1,5 F I G U R E 1 A, B, Lichenoid drug eruption. Widespread acute eczematous eruption on the trunk (A) and extremities (B) Proton-pump inhibitors are among the most commonly prescribed drugs.…”

Section: Discussionmentioning

confidence: 99%

“…LDEs have been reported to be associated with some medications including Proton-pump inhibitors (PPIs). 1 Proton-pump inhibitors are one of the most widely prescribed GI drugs that are approved for the treatment of gastric acid-related conditions. PPIs include omeprazole, esomeprazole, lansoprazole, rabeprazole, pantoprazole and dexlansoprazole.…”

Section: Introductionmentioning

confidence: 99%

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Persistent cutaneous lesion in a child with tyrosinemia: Esomeprazole‐induced lichenoid drug eruptions

Abtahi‐Naeini

Saneian²,

Dehghani

2021

Clinical Case Reports

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Persistent cutaneous lesion in a child with tyrosinemia: Esomeprazole‐induced lichenoid drug eruptions

Abtahi‐Naeini

Saneian²,

Dehghani

2021

Clinical Case Reports

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“…The incidence of LDE was known to be dependent on the causative drug rather than the dose [ 2 ]. LDE is less likely to resolve spontaneously and may require cessation of the offending agent in addition to corticosteroid therapy [ 16 ]. Therefore, in the case of clonazepam-induced LDE, it may be reasonable to discontinue the drug rather than to consider dose reduction.…”

Section: Discussionmentioning

confidence: 99%

Clonazepam-induced lichenoid drug eruption: a case report

Yang

Bae

et al. 2021

BMC Psychiatry

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Background Lichenoid drug eruption is rare and can mimic idiopathic lichen planus and other dermatoses. Clonazepam, a commonly used drug for the treatment of anxiety-related disorders and seizures, is known to be an unlikely cause of cutaneous adverse effects. Only one case report of LDE due to clonazepam has been reported. Case presentation A 81-year-old male patient with Alzheimer’s disease developed a lichenoid eruption after taking clonazepam. He developed a violaceous scaly patch on his lower extremities, from both buttocks to the feet. The cutaneous eruption resolved 2 months after cessation of clonazepam and with initiation of corticosteroid therapy. Conclusion A skin eruption that develops after clonazepam administration can be a lichenoid drug eruption, which is less likely to resolve spontaneously and requires discontinuation of clonazepam administration.

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“…Examining the interface dermatitis observed among patients using immune checkpoint inhibitors and reported as side effects, a preliminary evaluation may be considered before the use of these immune modulators in patients with autoimmune disease.The literature remains limited on the use of PD1, PDL1 as a treatment option in non-neoplastic conditions. In the studies mentioned, whether there is a predisposition for an autoimmune skin reaction or previous medications that cause sides effects in cases of LP and similar skin reactions observed secondary to treatment, plus many drugs might cause lichenoidstyle skin eruptions, and it is not known which causes the other (28,29). In the light of all these observations, considering the susceptibility to autoimmune diseases in the circumstances, it is thought that patients with a malignancy requiring the use of immune check point inhibitor drugs, especially those with 5% or more PD1 and PDL1 immunohistochemical expression, will have less side effects like interface dermatitis.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of PD1 and PDL1 Expressions in Squamous Cell Carcinoma and Lichen Planus

Erkılınç

Ertunç

Kiran

et al. 2021

Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi

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Programlı hücre ölümü 1 (PD1) T hücre ailesinde olan immün sistemi "down" regüle eden bir proteindir. PD ligandı 1 (PDL1) T hücre proliferasyonunu ve sitokin üretimini inhibe eden PD1 reseptör proteinidir. Dermiste lenfositik reaksiyon Liken Planusta (LP) lezyonun özelliği iken Skuamöz Hücreli Karsinomada (SHK) tümör hücrelerine karşı gelişen bir cevap olarak da izlenebilir. Çalışmamızda SHK ve LP'de PD1, PDL1'in epidermis ve lenfositik hücrelerdeki ekspresyonunu karşılaştırmayı amaçladık. Materyal ve Method: Retrospektif randomize olarak dermiste LHİ (lenfositik hücre infiltrasyonu) yaygın olan 31 SCC ve 38 LP tanılı olgu çalışmamıza dahil edildi. PD1, PDL1'in; SHK, LP' lerde dermisteki LHİ ekspresyonu ve epidermisteki hücrelerdeki ekspresyonları skorlandı. Bulgular: PD1'in LHİ skoru LP'lerde anlamlı şekilde skor 1 ve 2 sık görülür iken (sırasıyla %44.7, %34.2), SHK'larda çoğunlukla skor 0 (%67.7) idi. PD1'in LP, SHK'da skor 3 hiç görülmez iken her iki grupta skor 0 çoğunlukta saptandı (LP: %76.3, SHK %87.1). PDL1'in LHİ skoru LP, SHK'da çoğunlukla skor 2, 3 olarak saptandı. PDL1'in deri skoru LP'lerde skor 2 ve 3 hiç görülmezken SHK'larda skor 2 %9.7, skor 3 %6.5 oranında görüldü. Sonuç: PD1, PDL1 ile LP'lerin SHK'lara göre anlamlı şekilde lenfositik hücrelerde ekspresyonu, neoplastik durumlarda kullanımı sonrası yan etki olarak görülen LP ve benzeri deri reaksiyonlarını açıklayabileceğini düşünmekteyiz.

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Atorvastatin-induced Lichenoid Drug Eruption: A Case Report and Review of Statin-associated Cutaneous Adverse Events

Cited by 10 publications

References 16 publications

Persistent cutaneous lesion in a child with tyrosinemia: Esomeprazole‐induced lichenoid drug eruptions

Persistent cutaneous lesion in a child with tyrosinemia: Esomeprazole‐induced lichenoid drug eruptions

Clonazepam-induced lichenoid drug eruption: a case report

Evaluation of PD1 and PDL1 Expressions in Squamous Cell Carcinoma and Lichen Planus

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